Drug release stent coating
First Claim
1. A process for making an implantable medical prosthesis in which at least a portion of the prosthesis is covered with a coating, wherein the process comprises:
- (a) applying a composition, comprising a polymeric material incorporating a biologically active material, to the portion of the prosthesis to form a coating thereon;
(b) curing the coating;
(c) exposing the portion of the prosthesis to an inert gas plasma treatment after the coating is cured; and
(d) sterilizing the portion of the prosthesis with gamma radiation.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.
908 Citations
21 Claims
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1. A process for making an implantable medical prosthesis in which at least a portion of the prosthesis is covered with a coating, wherein the process comprises:
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(a) applying a composition, comprising a polymeric material incorporating a biologically active material, to the portion of the prosthesis to form a coating thereon;
(b) curing the coating;
(c) exposing the portion of the prosthesis to an inert gas plasma treatment after the coating is cured; and
(d) sterilizing the portion of the prosthesis with gamma radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A process for making an expandable stent in which at least a portion of the stent is covered with a coating, wherein the process comprises:
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(a) applying a composition, comprising a hydrophobic elastomeric material incorporating a biologically active material, to the portion of the stent to form a coating thereon;
(b) curing the coating;
(c) exposing the portion of the stent to an argon plasma treatment after the coating is cured; and
(d) sterilizing the portion of the stent with gamma radiation.
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21. A process for making an expandable stent in which at least a portion of the stent is covered with a coating, wherein the process comprises:
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(a) applying a composition, comprising a polymeric material incorporating a biologically active material, to the portion of the stent to form a coating thereon;
(b) curing the coating;
(c) exposing the portion of the stent to an argon plasma treatment for about 30 seconds to about 5 minutes after the coating is cured; and
(d) sterilizing the portion of the stent with gamma radiation of about 2.5 to about 3.4 Mrad.
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Specification