Graft polymerization of substrate surfaces
First Claim
1. A method of coating a substrate, comprising:
- exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
contacting the exposed substrate having reactive radical sites with a composition comprising one or more monomers in a medium which has reversed phase properties compared to the substrate, in terms of hydrophilicity and further comprising a solute in an amount sufficient to induce a salting-out effect; and
graft polymerizing onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface.
16 Assignments
0 Petitions
Accused Products
Abstract
The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly usefull as medical products such as catheters.
-
Citations
39 Claims
-
1. A method of coating a substrate, comprising:
-
exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
contacting the exposed substrate having reactive radical sites with a composition comprising one or more monomers in a medium which has reversed phase properties compared to the substrate, in terms of hydrophilicity and further comprising a solute in an amount sufficient to induce a salting-out effect; and
graft polymerizing onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 30, 31, 32, 33, 34, 35, 36, 37)
the initiator is an organic peroxide solution in tetrahydrofuran (THF);
the medium comprises from about 3% w/w to about 6% w/w acrylamide derivatives, from about 0.1% w/w to about 0.4% w/w diacrylate crosslinker, from about 10% w/w to about 20% w/w sodium chloride and from about 0.01% w/w to about 0.03% w/w poly(vinylpyrrolidone); and
,the reaction is allowed to proceed at a temperature from about 80°
C. to about 95°
C. at atmospheric pressure.
-
-
34. The method of claim 30, wherein the substrate is silicone;
-
the initiator is an organic peroxide solution in tetrahydrofuran (THF);
the medium comprises from about 1.0% w/w to about 3.0% w/w acrylamide derivatives, from about 3.0% w/w to about 5% w/w polyethylene glycol acrylate, from about 10% w/w to about 20% w/w sodium chloride and from about 1.0% w/w to about 3.0% w/w poly(vinylpyrrolidone); and
the reaction is allowed to proceed at a temperature from about 80°
C. to about 95°
C. at atmospheric pressure.
-
-
35. The method of claim 30, wherein the substrate is polyethylene;
-
the medium comprises from about 20% w/w to about 40% w/w acrylamide, from about 1% w/w to about 3% w/w polyvinylpyrrolidone, and from about 10% w/w to about 20% w/w sodium chloride; and
the reaction is allowed to proceed at a temperature from about 80°
C. to about 95°
C. at atmospheric pressure.
-
-
36. The method of claim 1, wherein the substrate is selected from the group consisting of silicone, polyethylene, polyamide and latex, and wherein the grafting coats the substrate surface with a coating having characteristics selected from the group consisting of lubricious, hydrophilic and elastic properties.
-
37. The method of claim 1, further comprising attaching to the coated substrate a biological agent selected from the group consisting of penicillins, cephalosporins, fluoroquinolones, aminoglycosides, silver compounds, phenols, and biguanides.
-
27. A method of coating a substrate, comprising:
-
exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
contacting the substrate with a composition comprising one or more monomers in a medium which has reversed phase properties compared to the substrate, in terms of hydrophilicity and a concentration of a solute sufficient to induce a salting-out effect, while mixing the composition;
graft polymerizing onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface; and
contacting the substrate with a cross-linking agent. - View Dependent Claims (28, 29)
-
-
38. A method of coating a substrate, comprising:
-
exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
contacting the substrate with a composition comprising one or more monomers in a medium and a concentration of a solute sufficient to induce a salting-out effect; and
graft polymerizing onto the substrate at a pressure less than about 50 atmospheres by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. - View Dependent Claims (39)
-
Specification