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Methods of identifying inverse agonists of the serotonin 2A receptor

  • US 6,358,698 B1
  • Filed: 10/06/1999
  • Issued: 03/19/2002
  • Est. Priority Date: 10/07/1998
  • Status: Expired due to Term
First Claim
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1. A method of identifying a compound with antipsychotic activity, the method comprising:

  • (a) contacting a 5-HT2A receptor having wild type constitutive activity with at least one test compound; and

    (b) determining any decrease in basal activity of the 5-HT2A receptor having wild type constitutive activity, wherein a decrease in basal activity of the 5-HT2A receptor identifies a compound with antipsychotic activity.

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