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Antisense inhibition of ras gene with chimeric and alternating oligonucleotides

  • US 6,359,124 B1
  • Filed: 02/12/1999
  • Issued: 03/19/2002
  • Est. Priority Date: 04/03/1995
  • Status: Expired due to Term
First Claim
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1. An oligonucleotide comprising from 8 to 30 nucleotide units specifically hybridizable with selected DNA or mRNA deriving from the human H-ras gene and containing a first region having at least one nucleosidic unit modified at the 2′

  • position with a 2′

    -O-methoxyethyl substituent and a second region having at least one phosphorothioate linkage.

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