Methods and products related to 16-HETE analogs

• US 6,359,158 B1
• Filed: 05/14/1999
• Issued: 03/19/2002
• Est. Priority Date: 05/15/1998
• Status: Expired due to Fees

• Current Assignee: New York Medical College (Touro College & University System), Board of Regents of the University of Texas System (University of Texas System), University of Vermont College of Agriculture and Life Sciences, University of Vermont & State Agricultural College
• Original Assignee: New York Medical College (Touro College & University System), Board of Regents of the University of Texas System (University of Texas System), University of Vermont & State Agricultural College
• Inventors: Gross, Cordell E., Balazy, Michael, Falck, John R., Bednar, Martin M.
• Primary Examiner(s): Carr, Deborah D.
• Application Number:
  US09/312,159
• Time in Patent Office: 1,040 Days
• Field of Search: 554/213, 554/224, 554/219
• US Class Current: 554/219
• CPC Class Codes: A61K 31/18 Sulfonamides compounds containing a para-N-benzene-sulfonyl-N- group A61K31/63
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 38/49 Urokinase; Tissue plasminogen activator
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07C 311/51 Y being a hydrogen or a carbon atom
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.

Claims

1. A compound of a 16-hydroxyeicosatetraenoic acid analog comprising a compound selected from the group consisting of:

2. The compound of claim 1 wherein the 16-hydroxyeicosatetraenoic acid analog is an agonist having the following structure:

3. The compound of claim 1 wherein the 16-hydroxyeicosatetraenoic acid analog is an agonist having the following structure: