System for imaging mechanically stabilized tissue

• US 6,360,115 B1
• Filed: 09/16/1999
• Issued: 03/19/2002
• Est. Priority Date: 08/18/1997
• Status: Expired due to Term

• Current Assignee: Caliber Imaging & Diagnostics, Inc., The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Lucid Inc., The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Greenwald, Roger J., Rajadhyaksha, Milind
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US09/397,329
• Time in Patent Office: 915 Days
• Field of Search: 600/407, 600/415, 600/425, 600/587, 600/417, 600/421, 600/429, 600/473, 600/476, 378/37, 378/62, 378/63, 378/195, 128/915
• US Class Current: 600/407
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: G02B 21/0012 Surgical microscopes counterbalanced structures for surgical microscopes G02B7/001
• CPC Class Codes: G02B 21/34 Microscope slides, e.g. mounting specimens on microscope slides

Abstract

A system is provided having a clamping apparatus with first and second members, which are spaced apart from each other. An attachment mechanism is connected to the first member for attaching the apparatus to a confocal imaging system. This attachment mechanism has a surface with a window facing the tissue to be examined. Opposing this surface is a third member connected to the second member. A clamping mechanism includes the first and second members for clamping the tissue between the surface of the attachment mechanism and the surface of the third member, thereby stabilizing the tissue to the confocal imaging system. The window of the attachment mechanism presents the clamped tissue to the confocal imaging system.

Claims

1. A system for imaging mechanically stabilized tissue comprising:

means for clamping the tissue by application of force to said tissue; and

an imaging system for imaging at least a portion of the clamped tissue attached to said clamping means, wherein said imaging system has optics for directing light into said clamped tissue in which said same optics receives returned reflected light from the clamped tissue representing microscopic images of the tissue.

2. The system according to claim 1 wherein said clamping means comprises:

a first member and a second member spaced apart and opposing said first member; and

means coupled to said first member for attaching said first member to said imaging system.

3. The system according to claim 1 wherein said clamping means provides an aperture through which said optics of said imaging system directs and receives light.

4. A method for mechanically stabilizing tissue to an imaging system comprising the steps of:

clamping the tissue by application of force to said tissue;

attaching the imaging system to the clamped tissue to present a limited view of an area of the clamped tissue; and

producing one or more images of said clamped tissue by returned reflected light.

5. The method according to claim 4 wherein said producing step is carried out with the aid of a confocal microscope.

6. The method according to claim 4 wherein said producing step is carried out in accordance with one of two-photo microscopy and optical coherence tomography.

7. The method according to claim 6 wherein said attaching step is carried out after said clamping step.

8. The method according to claim 4 wherein said attaching step is carried out before said clamping step.