Method and apparatus for brachytherapy treatment of prostate disease

• US 6,361,487 B1
• Filed: 03/09/2000
• Issued: 03/26/2002
• Est. Priority Date: 03/09/2000
• Status: Expired due to Fees

• Current Assignee: Neose Technologies, Inc.
• Original Assignee: Neose Technologies, Inc.
• Inventors: Horzewski, Michael J., Green, Thomas C.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): WINGOOD, PAMELA LYNN
• Application Number:
  US09/522,282
• Time in Patent Office: 747 Days
• Field of Search: 600/1, 600/2, 600/3, 600/4, 600/5, 600/6, 600/7, 600/8, 600/9-595
• US Class Current: 600/7
• CPC Class Codes: A61M 2210/166 Prostate
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

Methods and apparatus are provided for brachytherapy treatment of prostate disease. The apparatus comprises a housing, a plunger, a needle, and a lock. The plunger is rigidly affixed to the housing. The lock selectively restricts motion of the needle relative to the plunger. The needle comprises a screw thread that engages the housing or plunger. Rotation of the needle with respect to the housing/plunger causes distal advancement or proximal retraction of the needle with respect to the plunger, providing improved control over delivery of radioactive seeds to a diseased portion of a prostate.

Claims

1. Apparatus for performing brachytherapy comprising:

a housing having a bore and a first screw thread disposed along the bore;

a plunger affixed to the housing within, and extending out of, the bore; and

a needle having a proximal end, a sharpened distal end, a mating screw thread on an exterior surface of the needle near the proximal end, and a lumen extending between the proximal and distal ends,

wherein the plunger extends into the lumen when the mating screw thread engages the first screw thread.

2. The apparatus of claim 1 further comprising a lock configured to selectively restrict relative motion of the plunger with respect to the needle.

3. The apparatus of claim 2 wherein the needle further comprises a slot distal of the first screw thread, and the lock is removably received within the slot.

4. The apparatus of claim 1, wherein the housing further comprises a cord bore extending into the bore, the apparatus further comprising:

a swivel coupled to the proximal end of the needle; and

a cord coupled to the swivel and extending through the cord bore.

5. The apparatus of claim 1 further comprising a first swivel attached to the proximal end of the needle.

6. The apparatus of claim 5 further comprising a syringe swivel slidingly received within the bore of the housing, the syringe swivel coupled to the first swivel.

7. The apparatus of claim 6 wherein the housing comprises a first half and a second half, and a first hinge joining the first half to the second half.

8. The apparatus of claim 7 wherein the first hinge comprises a living hinge.

9. The apparatus of claim 7 wherein the syringe swivel comprises a first syringe half and a second syringe half, and a second hinge joining the first syringe half to the second syringe half.

10. The apparatus of claim 9 wherein the second hinge comprises a living hinge.

11. The apparatus of claim 1 wherein the housing further comprises a slot lumen, the slot lumen in communication with the lumen.

12. The apparatus of claim 11 further comprising a pull tab adapted to extend through the slot lumen to engage the needle.

13. The apparatus of claim 12 wherein the pull tab further comprises threads configured to engage the mating screw thread.

14. The apparatus of claim 1 wherein the needle further comprises measurement indicia for determining a depth of the plunger within the lumen.

15. Apparatus for performing brachytherapy comprising:

a housing having a bore;

a plunger affixed to the housing within, and extending out of, the bore, the plunger having a first screw thread disposed on an exterior surface of the plunger; and

a needle having a proximal end, a sharpened distal end, a lumen extending between the proximal and distal ends, and a mating screw thread disposed within the lumen near the proximal end,

wherein the plunger extends into the lumen when the mating screw thread engages the first screw thread.

16. The apparatus of claim 15 further comprising a lock configured to selectively restrict relative motion of the plunger with respect to the needle.

17. The apparatus of claim 16 wherein the needle further comprises a slot distal of the first screw thread, and the lock is removably received within the slot.

18. The apparatus of claim 15, wherein the housing further comprises a cord bore extending into the bore, the apparatus further comprising:

a swivel coupled to the proximal end of the needle; and

a cord coupled to the swivel and extending through the cord bore.

19. The apparatus of claim 15 further comprising a first swivel attached to the proximal end of the needle.

20. The apparatus of claim 19 further comprising a syringe swivel slidingly received within the bore of the housing, the syringe swivel coupled to the first swivel.

21. The apparatus of claim 20 wherein the housing comprises a first half and a second half, and a first hinge joining the first half to the second half.

22. The apparatus of claim 21 wherein the first hinge comprises a living hinge.

23. The apparatus of claim 21 wherein the syringe swivel comprises a first syringe half and a second syringe half, and a second hinge joining the first syringe half to the second syringe half.

24. The apparatus of claim 23 wherein the second hinge comprises a living hinge.

25. The apparatus of claim 15 wherein the needle further comprises measurement indicia for determining a depth of the plunger within the lumen.

26. A method of administering brachytherapy to a target location within a patient, the method comprising:

providing apparatus comprising a housing assembly with a bore and a plunger fixed within the bore, and a needle with a lumen configured to receive a distal end of the plunger, the needle configured to be received within the bore;

loading a plurality of radioactive seeds into the needle lumen;

receiving the distal end of the plunger within the needle lumen until the plunger contacts a distal-most of the plurality of radioactive seeds;

threadingly engaging a proximal end of the needle with the housing assembly;

inserting a sharpened distal tip of the needle into the target location within the patient until it is aligned with a reference plane;

rotating the housing assembly with respect to the needle to advance the plunger distally with respect to the needle and advance a proximal-most of the plurality of radioactive seeds to a distal tip of the needle; and

rotating the needle with respect to the housing assembly to retract the needle proximally relative to the plunger, thereby delivering the plurality of radioactive seeds in a row within the patient.

27. The method of claim 26 further comprising sequentially repeating the steps at additional target locations within the patient.

28. The method of claim 26 wherein the needle further comprises a swivel, and wherein proximally retracting the needle relative to the plunger comprises proximally retracting the swivel.

29. The method of claim 28 wherein the swivel comprises a syringe, and wherein proximally retracting the needle further comprises proximally retracting the syringe.

30. The method of claim 26 wherein providing apparatus further comprises providing a pull tab configured to threadingly engage the needle;

and

wherein proximally retracting the needle relative to the plunger further comprises moving the pull tab to rotate and retract the needle relative to the housing assembly.

31. The method of claim 26 further comprising, prior to inserting the sharpened distal tip of the needle into the target location, verifying that the plurality of radioactive seeds are within the needle lumen.