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Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

  • US 6,361,671 B1
  • Filed: 01/11/1999
  • Issued: 03/26/2002
  • Est. Priority Date: 01/11/1999
  • Status: Expired due to Term
First Claim
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1. A microfabricated capillary electrophoresis chip including a substrate with an elongated, narrow separation channel which widens into a detection reservoir and means for applying a separation voltage along the channel, two or more thin film working electrodes each adapted to receive a different working voltage extending into said detection reservoir opposite and near the end of said narrow separation channel where the working electrodes have minimal influence from the high electrophoresis potentials, said working electrodes simultaneously detecting current generated by molecules undergoing redox reaction as they migrate past the thin film electrodes after they have migrated down the channel and a ground electrode adapted to be connected to said means for applying a separation voltage along the channel and a reference electrode adapted to be connected to a reference voltage, both in said detection reservoir spaced from said working electrodes.

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