On line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population
First Claim
1. An on line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population comprisinga tubing system operative for establishing on line communication between a storage container for the blood suspension and a source of blood containing leukocytes, a device communicating with the tubing system operative for creating, without interrupting the on line communication between the storage container and the source of blood when in use, a centrifugal field that generates separation forces to separate from the blood a first blood suspension having an initial population of leukocytes, a finishing device communicating with the tubing system outside the centrifugal field operative, in response to contact with the first blood suspension when in use, for reducing the initial leukocyte population in the first blood suspension, thereby creating a second blood suspension having a reduced residual leukocyte population less than the initial population of leukocytes, a pump communicating with the tubing system operative, without interrupting the on line communication between the storage container and the source of blood when in use, for pumping the first blood suspension outside the centrifugal field through the finishing device under pressure from the centrifugal field, and tubing communicating with the tubing system outside the centrifugal field operative, without interrupting the on line communication between the storage container and the source of blood when in use, for conveying the second blood suspension from the finishing device directly into the storage container without exposure to the separation forces of the centrifugal field.
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Accused Products
Abstract
Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.
46 Citations
4 Claims
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1. An on line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population comprising
a tubing system operative for establishing on line communication between a storage container for the blood suspension and a source of blood containing leukocytes, a device communicating with the tubing system operative for creating, without interrupting the on line communication between the storage container and the source of blood when in use, a centrifugal field that generates separation forces to separate from the blood a first blood suspension having an initial population of leukocytes, a finishing device communicating with the tubing system outside the centrifugal field operative, in response to contact with the first blood suspension when in use, for reducing the initial leukocyte population in the first blood suspension, thereby creating a second blood suspension having a reduced residual leukocyte population less than the initial population of leukocytes, a pump communicating with the tubing system operative, without interrupting the on line communication between the storage container and the source of blood when in use, for pumping the first blood suspension outside the centrifugal field through the finishing device under pressure from the centrifugal field, and tubing communicating with the tubing system outside the centrifugal field operative, without interrupting the on line communication between the storage container and the source of blood when in use, for conveying the second blood suspension from the finishing device directly into the storage container without exposure to the separation forces of the centrifugal field.
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3. An on line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population comprising
a flow path operative for establishing on line communication between a storage container for the blood suspension and a source of blood containing leukocytes, a separation device communicating in line with the flow path between the source and the container to receive blood from the source, the separation device including a centrifugal separation element operative, without interrupting the on line communication between the container and the source of blood when in use, for creating a centrifugal field that generates separation forces to separate from the blood a first blood suspension having an initial population of leukocytes, a finishing device communicating in line with the flow path outside the centrifugal field, the finishing device including an inlet communicating with the separation device and an outlet communicating with the storage container and not the separation device, the finishing device including a finishing element operative, during passage of the first blood suspension between the inlet and outlet when in use, for reducing the initial leukocyte population in the first blood suspension to a reduced residual leukocyte population less than the initial population of leukocytes, and a pump in line with the flow path operative, without interrupting the on line communication between the flow path and the blood source when in use, for pumping the first blood suspension outside the centrifugal field through the finishing device inlet under pressure from the centrifugal field for passage through the finishing element, to thereby change the first blood suspension into a second blood suspension having the reduced residual leukocyte population, the pump also being operative when in use for pumping the second blood suspension from the finishing device outlet directly into the storage container without exposure to the separation forces of the centrifugal field.
Specification