Monitoring the occurrence of apneic and hypopneic arousals

• US 6,363,270 B1
• Filed: 12/16/1999
• Issued: 03/26/2002
• Est. Priority Date: 04/11/1995
• Status: Expired due to Term

• Current Assignee: Resmed Limited (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Colla, Gregory Alan, Brydon, John William Ernest
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/465,048
• Time in Patent Office: 831 Days
• Field of Search: 600/306, 600/324, 600/483, 600/484, 600/529, 600/547
• US Class Current: 600/324
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/4818 Sleep apnoea

Abstract

The occurrence of an arousal in a patient associated with an apneic or hypopneic episode car be determined. Sensors are placed on a patient to obtain signals representative of at least two physiological variables, for example skin conductance, heart rate and blood oxygen concentration. The signals are conditioned by conditioning circuitry, then processed by a processor to correlate at least two thereof. A coincident change in at least two of the processed signals is indicative of the occurrence of an arousal, that in turn indicates an apneic or hypopneic episode has occurred. A patient thus can be diagnosed as suffering conditions such as obstructive sleep apnea.

Claims

1. A method for the determination for a patient of an index of sleep quality, the method comprising the steps of:

obtaining two or more signals from the patient, each signal representative of a physiological variable;

correlating said two or more signals; and

recording instances where there is a coincident change in said correlated signals, the number of instances of coincidence being proportional to said index, and the number of instances of coincidence being scaled linearly to give said index.

2. A method as claimed in claim 1, comprising the further step of storing said signals as a time sequence, and performing said correlation only upon completion of said signal obtaining step.

3. A method as claimed in claim 1, wherein said physiological variables are associated only with the sympathetic nervous system.

4. Apparatus for monitoring the occurrence of sympathetic arousals associated with apneic or hypopneic episodes, the apparatus comprising:

sensor means for obtaining two or more signals from a patient, each signal representative of a sympathetic physiological variable;

means for correlating said two or more signals, a coincident change in at least two of said signals being indicative of the occurrence of an arousal; and

means for recording the occurrence of arousals.

5. A method for monitoring the occurrence of sympathetic arousals associated with apneic or hypopneic episodes, the method comprising the steps of:

obtaining two or more signals from a patient, each signal representative of a sympathetic physiological variable;

correlating said two or more signals whereby a coincident change in at least two of said signals is indicative of the occurrence of a said arousal; and

recording the occurrence of arousals.

6. Apparatus for determining occurrence of at least one of apneic and hypopneic arousals in a patient, comprising:

a skin conductance sensor connectable to an extremity of the patient;

apparatus, associated with the skin conductance sensor, that processes output of the skin conductance sensor to determine whether the skin conductance sensor output indicates at least one of an apneic and an hypopneic arousal;

a heart rate sensor connectable to an extremity of the patient;

apparatus, associated with the heart rate sensor, that processes output of the heart rate sensor to determine whether the heart rate sensor output indicates at least one of an apneic and a hypopneic arousal; and

apparatus that determines whether a positive indicator in skin conductance coincides with a positive indicator in heart rate.

7. Apparatus as claimed in claim 6, wherein the extremity to which the skin conductance sensor is connectable is the sole of the patient'"'"'s foot.

8. Apparatus as claimed in claim 6, wherein the extremity to which the skin conductance sensor is connectable is the patient'"'"'s forehead.

9. Apparatus as claimed in claim 6, wherein the heart rate is measured using a three lead ECG.

10. Apparatus as claimed in claim 6, wherein the heart rate is measured using a pulse oximeter.

11. A method of determining occurrence of at least one of apneic and hypopneic arousals in a patient in an overnight study, comprising:

monitoring variation in a patient'"'"'s skin conductance and at least one other physiological variable indicative of sympathetic nervous system activity;

providing no CPAP treatment during a first portion of the overnight study;

providing CPAP treatment during a second portion of the overnight study; and

determining that at least one of an apneic and a hypopneic arousal has occurred when a positive indicator in skin conductance coincides with a positive indicator in said at least one other physiological variable.

12. A method as claimed in claim 11, wherein the first portion of the overnight study occurs from approximately 20:

30 hours to 1;

15 hours.

13. A method as claimed in claim 11, wherein the second portion of the overnight study occurs from approximately 1:

15 hours to 5;

30 hours.

14. A method as claimed in claim 11, further including determining an index of sleep quality from a number of apneic and hypopneic arousals that have been determined during the overnight study.