Bioadhesive microspheres and their use as drug delivery and imaging systems
First Claim
1. A drug formulation comprising drug encapsulated within a microsphere having a polymeric surface with an adhesive force equivalent to an adhesive force of between 110 N/m2 and 100,000 N/m2 measured on rat intestine, wherein the drug is selected from the group consisting of antibiotics, antivirals, anti-parasites (helminths, protozoans), anti-cancer, antibodies and bioactive fragments thereof, antigen and vaccine formulations, peptide drugs, anti-inflammatories, and oligonucleotide drugs.
5 Assignments
0 Petitions
Accused Products
Abstract
Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm2 (110 N/m2) Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.
194 Citations
23 Claims
- 1. A drug formulation comprising drug encapsulated within a microsphere having a polymeric surface with an adhesive force equivalent to an adhesive force of between 110 N/m2 and 100,000 N/m2 measured on rat intestine, wherein the drug is selected from the group consisting of antibiotics, antivirals, anti-parasites (helminths, protozoans), anti-cancer, antibodies and bioactive fragments thereof, antigen and vaccine formulations, peptide drugs, anti-inflammatories, and oligonucleotide drugs.
- 18. A method for delivering a drug comprising administering to a mucosal surface a drug formulation comprising drug encapsulated within a microsphere having a synthetic polymeric surface with an adhesive force equivalent to an adhesive force of between 110 N/m2 and 100,000 N/m2 measured on rat intestine, wherein the drug is selected from the group consisting of antibiotics, antivirals, anti-parasites (helminths, protozoans), anti-cancer, antibodies and bioactive fragments thereof, antigen and vaccine formulations, peptide drugs, anti-inflammatories, imaging agents and oligonucleotide drugs, in combination with a pharmaceutical carrier.
Specification