Fiber optic probes for indwelling investigations

• US 6,366,726 B1
• Filed: 02/24/2000
• Issued: 04/02/2002
• Est. Priority Date: 11/20/1995
• Status: Expired due to Term

• Current Assignee: Cirrex Systems, LLC
• Original Assignee: Cirrex Corp. (Cirrex Systems, LLC)
• Inventors: Marple, Eric Todd, Wach, Michael Leonard
• Primary Examiner(s): Palmer, Phan T. H.
• Application Number:
  US09/512,564
• Time in Patent Office: 768 Days
• Field of Search: 285/115, 285/116, 285/120, 285/122, 285/123, 285/12, 356/402, 250/227.14, 250/227.15, 128/667
• US Class Current: 385/115
• CPC Class Codes: G01N 2021/656 Raman microprobe
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 21/65 Raman scattering
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G02B 6/02052 comprising optical elements other than gratings, e.g. filters comprising gratings G02B6/02057
• CPC Class Codes: G02B 6/04 formed by bundles of fibres G02B6/24 takes precedence
• CPC Class Codes: G02B 6/241 Light guide terminations
• CPC Class Codes: G02B 6/262 Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
• CPC Class Codes: G02B 6/29362 Serial cascade of filters or filtering operations, e.g. for a large number of channels
• CPC Class Codes: G02B 6/29364 Cascading by a light guide path between filters or filtering operations, e.g. fibre interconnected single filter modules
• CPC Class Codes: G02B 6/29368 Light guide comprising the filter, e.g. filter deposited on a fibre end G02B6/29359 takes precedence
• CPC Class Codes: G02B 6/29388 for lighting or use with non-coherent light
• CPC Class Codes: G02B 6/4203 Optical features

Abstract

Fiber optic probe assemblies for monitoring light-matter interactions in a medium of interest. The distal end of the probe assemblies can be immersed in the medium for in-situ light delivery and collection. The probe assemblies are particularly useful for indwelling biomedical applications. Design variations include paired fiber configurations and center/ring fiber configurations.

Claims

1. A fiber optic probe assembly for monitoring light-matter interactions in a biological medium, comprising:

a center optical fiber having a center distal end;

a plurality of ring optical fibers each having a ring distal end;

the center and ring optical fibers being parallel to each other at their respective distal ends and being adapted for positioning adjacent the biological medium;

wherein the center distal end is adapted to illuminate the biological medium with light delivered to the center distal end by the center optical fiber; and

wherein the ring distal ends are adapted to collect light from the biological medium at the ring distal ends and to deliver collected light to the ring optical fibers.

2. The fiber optic probe assembly according to claim 1 wherein the center distal end comprises a surface of revolution about the axis of the center distal end.

3. The fiber optic probe assembly according to claim 2 wherein the surface of revolution is a cone.

4. The fiber optic probe assembly according to claim 2 wherein the surface of revolution is a paraboloid of revolution.

5. The fiber optic probe assembly according to claim 2 wherein the ring distal ends are disposed symmetrically about the axis of the center distal end.

6. The fiber optic probe assembly according to claim 2 wherein each of the ring distal ends comprises a flat face formed at an oblique angle relative to the axis of the respective ring distal end.

7. The fiber optic probe assembly according to claim 1 wherein the center distal end extends along its axis beyond the ring distal ends.

8. The fiber optic probe assembly according to claim 1 further comprising an internally reflecting end piece for directing collected light to the ring distal ends, wherein the end piece is rotationally symmetrical about the axis of the center distal end.

9. The fiber optic probe assembly according to claim 1 wherein each of the ring distal ends comprises a flat face formed at an oblique angle relative to the axis of the respective ring distal end.

10. The fiber optic probe assembly according to claim 1 wherein each of the ring distal ends comprises a surface of revolution about the axis of the center distal end.

11. The fiber optic probe assembly according to claim 1 wherein the center distal end comprises a first filter.

12. The fiber optic probe assembly according to claim 1 wherein the center distal end and the ring distal ends are adapted to be integrated into a medical instrument.

13. The fiber optic probe assembly according to claim 1 further comprising a source of substantially monochromatic light in optical communication with at least one of the center optical fiber and the ring optical fibers.

14. The fiber optic probe assembly according to claim 1 further comprising a spectrographic detector in optical communication with at least one of the center optical fiber and the ring optical fibers.

15. The fiber optic probe assembly according to claim 1 wherein the center and ring optical fiber distal ends are adapted to be detachable from the respective center optical fiber and ring optical fibers.

16. The fiber optic probe assembly according to claim 1 wherein the center and ring optical fiber distal ends are adapted to flexibly move relative to the respective center optical fiber and ring optical fibers.

17. The fiber optic probe assembly according to claim 1 wherein the center and ring distal ends comprise reflective surfaces to manage the delivery and collection of light to and from the biological medium.

18. A fiber optic probe assembly for monitoring light-matter interactions in a medium, comprising:

a first optical fiber having a first distal end;

a second optical fiber having a second distal end;

the first and second optical fibers being positioned adjoining and parallel to each other at their respective distal ends and being adapted for immersion in the medium;

wherein the first distal end is adapted to illuminate the medium with light delivered to the first distal end by the first optical fiber; and

wherein the second distal end is adapted to collect light from the medium at the second distal end and to deliver collected light to the second optical fiber.

19. The fiber optic probe assembly according to claim 18 wherein the first distal end comprises a first flat face formed at an oblique angle relative to the axis of the first optical fiber.

20. The fiber optic probe assembly according to claim 19 wherein the second distal end comprises a second flat face formed at an oblique angle relative to the axis of the second optical fiber.

21. The fiber optic probe assembly according to claim 20 wherein the first flat face and the second flat face are parallel.

22. The fiber optic probe assembly according to claim 21 wherein one of the first flat face and the second flat face comprises a notch filter adapted to reflect the light delivered to the first distal end and to pass wavelength-shifted light collected from the medium.

23. The fiber optic probe assembly according to claim 22 wherein the first optical fiber comprises a second filter adapted to filter wavelength-shifted light created by fiber fluorescence phenomena and silica-Raman scattering within the first optical fiber.

24. The fiber optic probe assembly according to claim 20 wherein the first flat face and the second flat face are symmetrical with respect to each other about the plane of symmetry defined by the axes of the first and second optical fibers.

25. The fiber optic probe assembly according to claim 19 wherein one of the first flat face and the second flat face comprises a first filter.

26. The fiber optic probe assembly according to claim 25 wherein the first filter comprises a thin-film interference filter.

27. The fiber optic probe assembly according to claim 26 wherein the interference filter comprises a plurality of layers having alternating refractive indices.

28. The fiber optic probe assembly according to claim 25 wherein one of the first flat face and the second flat face comprises a reflective surface.

29. The fiber optic probe assembly according to claim 18 wherein the first distal end comprises a curved surface to deliver light to the medium at a plurality of angular orientations.

30. The fiber optic probe assembly according to claim 29 wherein the curved surface is a paraboloid of revolution.

31. The fiber optic probe assembly according to claim 29 wherein the first distal end further comprises a flat surface to deliver light into the medium.

32. The fiber optic probe assembly according to claim 29 wherein the curved surface is rotationally symmetrical about the axis of the second optical fiber.

33. The fiber optic probe assembly according to claim 18 wherein the first optical fiber comprises a filter adapted to filter wavelength-shifted light created by fiber fluorescence and silica-Raman scattering within the first optical fiber.

34. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends are adapted to be integrated into a needle.

35. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends are adapted to be integrated into an endoscope.

36. The fiber optic probe assembly according to claim 18 further comprising a source of substantially monochromatic light in optical communication with the first optical fiber.

37. The fiber optic probe assembly according to claim 18 further comprising a spectrographic detector in optical communication with the second optical fiber.

38. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends are adapted to be detachable from the respective first and second optical fibers.

39. The fiber optic probe assembly according to claim 38 wherein the first distal end comprises a first flat face formed at an oblique angle relative to the axis of the first optical fiber;

wherein the second distal end comprises a second flat face formed at an oblique angle relative to the axis of the second optical fiber; and

wherein the first flat face comprises a filter.

40. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends are adapted to flexibly move relative to the first and second optical fibers.

41. The fiber optic probe assembly according to claim 40 wherein the first distal end comprises a first flat face formed at an oblique angle relative to the axis of the first optical fiber;

wherein the second distal end comprises a second flat face formed at an oblique angle relative to the axis of the second optical fiber; and

wherein the first flat face comprises a filter.

42. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends comprise reflective surfaces to manage the delivery and collection of light to and from the medium.

43. The fiber optic probe assembly according to claim 18 wherein the first and second distal ends are adapted to be integrated into a catheter.

44. A fiber optic probe assembly for monitoring light-matter interactions in a medium, comprising:

a center optical fiber having a center distal end;

a plurality of ring optical fibers each having a ring distal end;

the center and ring optical fibers being parallel to each other at their respective distal ends and being adapted for immersion in the medium;

wherein the center distal end is adapted to illuminate the medium with light delivered to the center distal end by the center optical fiber; and

wherein the ring distal ends are adapted to collect light from the medium at the ring distal ends and to deliver collected light to the ring optical fibers.

45. The fiber optic probe assembly according to claim 44 wherein the center distal end comprises a surface of revolution about the axis of the center distal end.

46. The fiber optic probe assembly according to claim 45 wherein the surface of revolution is a paraboloid of revolution.

47. The fiber optic probe assembly according to claim 45 wherein the surface of revolution is a cone.

48. The fiber optic probe assembly according to claim 45 wherein the ring distal ends are disposed symmetrically about the axis of the center distal end.

49. The fiber optic probe assembly according to claim 45 wherein each of the ring distal ends comprises a flat face formed at an oblique angle relative to the axis of the respective ring distal end.

50. The fiber optic probe assembly according to claim 44 further comprising an internally reflecting end piece for directing collected light to the ring distal ends, wherein the end piece is rotationally symmetrical about the axis of the center distal end.

51. The fiber optic probe assembly according to claim 44 wherein each of the ring distal ends comprises a flat face formed at an oblique angle relative to the axis of the respective ring distal end;

and

wherein the ring distal ends extend beyond the center distal end to thereby define a volume into which the medium may be placed.

52. The fiber optic probe assembly according to claim 51 further comprising an end window positioned adjacent to and rotationally symmetrical about the center distal end.

53. The fiber optic probe assembly according to claim 44 wherein each of the ring distal ends comprises a surface of revolution about the axis of the center distal end.

54. The fiber optic probe assembly according to claim 53 wherein the surfaces of revolution are paraboloids of revolution.

55. The fiber optic probe assembly according to claim 44 wherein the center distal end comprises a first filter.

56. The fiber optic probe assembly according to claim 55 wherein the first filter comprises a thin-film interference filter.

57. The fiber optic probe assembly according to claim 44 wherein the center distal end and the ring distal ends are adapted to be integrated into a catheter.

58. The fiber optic probe assembly according to claim 44 wherein the center distal end and the ring distal ends are adapted to be integrated into a needle.

59. The fiber optic probe assembly according to claim 44 wherein the center distal end and the ring distal ends are adapted to be integrated into an endoscope.

60. The fiber optic probe assembly according to claim 44 further comprising a source of substantially monochromatic light in optical communication with at least one of the center optical fiber and the ring optical fibers.

61. The fiber optic probe assembly according to claim 44 further comprising a spectrographic detector in optical communication with at least one of the center optical fiber and the ring optical fibers.

62. The fiber optic probe assembly according to claim 44 wherein the center and ring optical fiber distal ends are adapted to be detachable from the respective center optical fiber and ring optical fibers.

63. The fiber optic probe assembly according to claim 44 wherein the center and ring optical fiber distal ends are adapted to flexibly move relative to the respective center optical fiber and ring optical fibers.

64. The fiber optic probe assembly according to claim 44 wherein the center and ring distal ends comprise reflective surfaces to manage the delivery and collection of light to and from the medium.

65. The fiber optic probe assembly according to claim 44 wherein the center distal end extends along its axis beyond the ring distal ends.

66. A fiber optic probe assembly for monitoring light-matter interactions in a biological medium, comprising:

a first optical fiber having a first distal end,

a second optical fiber having a second distal end;

the first and second optical fibers being positioned adjacent and parallel to each other at their respective distal ends and being adapted for positioning adjacent the biological medium;

wherein the first distal end is adapted to illuminate the biological medium with light delivered to the first distal end by the first optical fiber; and

wherein the second distal end is adapted to collect light from the biological medium at the second distal end and to deliver collected light to the second optical fiber.

67. The fiber optic probe assembly according to claim 66 wherein the first distal end comprises a first flat face formed at an oblique angle relative to the axis of the first optical fiber.

68. The fiber optic probe assembly according to claim 67 wherein the second distal end comprises a second flat face formed at an oblique angle relative to the axis of the second optical fiber.

69. The fiber optic probe assembly according to claim 67 wherein one of the first flat face and the second flat face comprises a first filter.

70. The fiber optic probe assembly according to claim 66 wherein the first distal end comprises a curved surface to deliver light to the biological medium at a plurality of angular orientations.

71. The fiber optic probe assembly according to claim 66 wherein the first optical fiber comprises a filter adapted to filter wavelength-shifted light created by fiber fluorescence and silica-Raman scattering within the first optical fiber.

72. The fiber optic probe assembly according to claim 66 wherein the first and second distal ends are adapted to be integrated into a medical instrument.

73. The fiber optic probe assembly according to claim 66 further comprising a source of substantially monochromatic light in optical communication with the first optical fiber.

74. The fiber optic probe assembly according to claim 66 further comprising a spectrographic detector in optical communication with the second optical fiber.

75. The fiber optic probe assembly according to claim 66 wherein the first and second distal ends are adapted to be detachable from the respective first and second optical fibers.

76. The fiber optic probe assembly according to claim 66 wherein the first and second distal ends are adapted to flexibly move relative to the first and second optical fibers.

77. The fiber optic probe assembly according to claim 66 wherein the first and second distal ends comprise reflective surfaces to manage the delivery and collection of light to and from the biological medium.

78. A method for fabricating a fiber optic probe assembly, comprising the steps of:

forming a bundle of optical fibers including a center optical fiber surrounded by a plurality of ring optical fibers, the ring fibers and the center fibers being mutually parallel at their respective distal ends;

fusing the bundle of optical fibers together;

shaping the distal end of the center optical fiber so that it is adapted to illuminate a medium of investigation; and

shaping the ring optical fibers so that they are adapted to collect light from the medium of investigation.

79. The method according to claim 78 wherein the center fiber shaping step comprises the step of forming a surface of revolution about the axis of the distal end of the center optical fiber.

80. The method according to claim 78 wherein the ring fiber shaping step comprises the step of forming, at the distal end of at least one of the ring optical fibers, a flat face formed at an oblique angle relative to the axis of the distal end of the respective ring optical fiber.

81. The method according to claim 78 wherein the ring fiber shaping step comprises the step of forming, at the distal end of at least one of the ring optical fibers, a surface of revolution about the axis of the distal end of the center optical fiber.

82. The method according to claim 81 wherein the surface of revolution forming step comprises the step of forming a paraboloid of revolution about the axis of the distal end of the center optical fiber.

83. The method according to claim 78 further comprising the step of forming a thin-film interference filter on the distal end of the center optical fiber.

84. The method according to claim 78 further comprising the step of forming a thin-film interference filter on the distal end of at least one of the ring optical fibers.

85. A method for fabricating a fiber optic probe assembly, comprising the steps of:

forming a pair of optical fibers including a first optical fiber and a second optical fiber, the first and second optical fibers being positioned adjoining and parallel to each other at their respective distal ends;

fusing the pair of optical fibers together;

shaping the distal end of the first optical fiber so that it is adapted to illuminate a medium of investigation; and

shaping the distal end of the second optical fiber so that it is adapted to collect light from the medium of investigation.

86. The method according to claim 85 wherein the first fiber shaping step comprises the step of forming, at the distal end of the first optical fiber, a flat face at an oblique angle relative to the axis of the first optical fiber.

87. The method according to claim 85 wherein the second fiber shaping step comprises the step of forming, at the distal end of the second optical fiber, a flat face at an oblique angle relative to the axis of the second optical fiber.

88. The method according to claim 85 wherein the first fiber shaping step comprises forming, at the first fiber distal end, a curved surface for delivering light at a plurality of angular orientations.

89. The method according to claim 85 further comprising the step of forming a thin-film interference filter on the distal end of at least one of the first and second optical fibers.