Extraction of hemodynamic pulse pressure from fluid and myocardial accelerations

• US 6,366,811 B1
• Filed: 12/30/1999
• Issued: 04/02/2002
• Est. Priority Date: 10/13/1998
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Carlson, Gerrard M.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/475,860
• Time in Patent Office: 824 Days
• Field of Search: 607/9, 607/27, 607/18-20, 607/23, 607/17, 600/519, 600/513, 600/483, 600/485, 600/509, 600/526
• US Class Current: 607/27
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A cardiac stimulating apparatus and method is described that non-intrusively determines an amount indicative of hemodynamic pulse pressure from an accelerometer signal. The amount indicative of pulse pressure is determined over several cardiac cycles and is used to optimize cardiac performance by evaluating the amount indicative of pulse pressure over varying timing intervals. The timing intervals are measured between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart and a maximum pulse pressure indicates the optimum timing interval under manipulation. The cardiac stimulating apparatus and method may be used in any of several pacing modes including A-V pacing, V-V pacing, or A-A pacing.

Claims

1. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, a linear prediction means for predicting values associated with the waveform, and means for determining an amount indicative of pulse pressure from said waveform.

2. The cardiac stimulating apparatus as recited in claim 1, whereby the determined amount indicative of pulse pressure is analyzed and compared by said controller over a preselected number of cardiac cycles for a plurality of preselected timing intervals, said timing intervals being a time between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart, to thereby determine an optimum timing interval.

3. The cardiac stimulating apparatus as recited in claim 1, wherein the linear prediction means further includes a means for auto-regressive analysis of the preconditioned accelerometer energy signal using algorithms selected from the group consisting of Levinson and Yule-Walker.

4. The cardiac stimulating apparatus as recited in claim 1, wherein said controller includes a means for identifying, from the signal transmitted by the accelerometer, a time of physical inactivity.

5. The cardiac stimulating apparatus as recited in claim 1, wherein the dual chamber cardiac pacer functions in a pacing mode selected from the group consisting of A-V pacing, V-V pacing and A-A pacing.

6. The cardiac stimulating apparatus as recited in claim 5, wherein the A-V pacing mode is selected from the group consisting of A_R-V_R pacing, A_R-V_L pacing, A_L-V_R pacing, A_R-V_RL pacing, A_L-V_RL pacing, and A_L-V_L pacing.

7. The cardiac stimulating apparatus as recited in claim 1, wherein said controller includes bandwidth determining means for determining a bandwidth from predicted values of the waveform.

8. The cardiac stimulating apparatus as recited in claim 7, wherein said controller further includes a center frequency determining means for determining a center frequency from predicted values of the waveform.

9. The cardiac stimulating apparatus as recited in claim 8, wherein said controller determines the amount indicative of pulse pressure from the determined bandwidth and center frequency.

10. The cardiac stimulating apparatus as recited in claim 1, wherein said controller further includes analyzing means for analyzing the amounts indicative of pulse pressure over corresponding cardiac cycles.

11. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means for determining an amount indicative of pulse pressure from said waveform, said amount indicative of pulse pressure being analyzed and compared by said controller over a preselected number of cardiac cycles for a plurality of preselected timing intervals, said timing intervals being a time between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart, to thereby determine an optimum timing interval.

12. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means for determining an amount indicative of pulse pressure from said waveform, said means for determining including means for auto-regressive analysis of said waveform using algorithms selected from the group consisting of Levinson and Yule Walker.

13. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, means responsive to the signal transmitted by the accelerometer for identifying a time of physical inactivity and means for determining an amount indicative of pulse pressure from said waveform.

14. A cardiac stimulating apparatus functioning in a preset mode selected from the group consisting of A-V pacing, V-V pacing and A-A pacing and having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means for determining an amount indicative of pulse pressure from said waveform.

15. The cardiac stimulating apparatus as recited in claim 14, wherein the A-V pacing mode is selected from the group consisting of A_R-V_R pacing, A_R-V_L pacing, A_L-V_R pacing, A_R-V_RL pacing, A_L-V_RL pacing, and A_L-V_L pacing.

16. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, bandwidth determining means for determining a bandwidth from preselected values of the waveform and means for determining an amount indicative of pulse pressure from said waveform.

17. The cardiac stimulating apparatus as recited in claim 16, wherein said controller further includes a center frequency determining means for determining a center frequency from predicted values of the waveform.

18. The cardiac stimulating apparatus as recited in claim 17, wherein said controller determines the amount indicative of pulse pressure from the determined bandwidth and center frequency.

19. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and analyzing means for analyzing the amounts indicative of pulse pressure over corresponding cardiac cycles.

20. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means for determining an amount indicative of pulse pressure from said waveform, the determined amount indicative of pulse pressure being analyzed and compared by said controller over a preselected number of cardiac cycles for a plurality of preselected timing intervals, said timing intervals being a time between at least one of intrinsic and paced stimulations of preselected chambers of the heart, to thereby determine an optimum timing interval.

21. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, means for auto-regressive analysis of said waveform using algorithms selected from the group consisting of Levinson and Yule-Walker and means for determining an amount indicative of pulse pressure from said waveform.

22. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means responsive to the signal transmitted by the accelerometer for identifying a time of physical inactivity, and means for determining an amount indicative of pulse pressure from said waveform.

23. A cardiac stimulating apparatus functioning in a preset pacing mode, said mode selected from the group consisting of A-V pacing, V-V pacing and A-A pacing and having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart and means for determining an amount indicative of pulse pressure from said waveform.

24. The cardiac stimulating apparatus as recited in claim 23, wherein the A-V pacing mode is selected from the group consisting of A_R-V_R pacing, A_R-V_L pacing, A_L-V_R pacing, A_R-V_RL pacing, A_L-V_RL pacing, and A_L-V_L pacing.

25. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, bandwidth determining means for determining a bandwidth from predicted values of the waveform and means for determining an amount indicative of pulse pressure from said waveform.

26. The cardiac stimulating apparatus as recited in claim 25, wherein said controller further includes a center frequency determining means for determining a center frequency from predicted values of the waveform.

27. The cardiac stimulating apparatus as recited in claim 26, wherein said controller determines the amount indicative of pulse pressure from the determined bandwidth and center frequency.

28. A cardiac stimulating apparatus functioning in a preset pacing mode having preset pacing rates and timing intervals, and programmed to optimize cardiac performance of a patient'"'"'s heart, said cardiac stimulating apparatus comprising:

a) a pulse generator;

b) an accelerometer enclosed in a casing of the cardiac stimulating apparatus and electrically coupled to a controller of the cardiac stimulating apparatus, said accelerometer transmitting a signal associated with fluid and myocardial accelerations of the patient'"'"'s heart;

c) filtering means coupled to the accelerometer for filtering and conditioning the signal transmitted by the accelerometer to produce a waveform related to a pulse pressure within the patient'"'"'s heart; and

d) said controller including a timing means for identifying cardiac cycles of the patient'"'"'s heart, means for determining an amount indicative of pulse pressure from said waveform and analyzing means for analyzing the amounts indicative of pulse pressure over corresponding cardiac cycles.