Administration of CPAP treatment pressure in presence of APNEA

• US 6,367,474 B1
• Filed: 01/19/1998
• Issued: 04/09/2002
• Est. Priority Date: 11/07/1997
• Status: Expired due to Term

• Current Assignee: Resmed Limited (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Farrugia, Steven Paul, Berthon-Jones, Michael
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): PATEL, MITAL B
• Application Number:
  US09/008,743
• Time in Patent Office: 1,541 Days
• Field of Search: 128/204.21, 128/204.23, 128/204.26, 128/204.18
• US Class Current: 128/204.23
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0875 Connecting tubes
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase

Abstract

CPAP treatment apparatus having a controllable flow generator operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube coupled to a mask having a connection with a patient'"'"'s airway. A sensor generates a signal representative of patient respiratory flow that is provided to a controller. The controller is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator to increase the treatment pressure by an amount which is an increasing function of the duration of the apnea, and a decreasing function of the treatment pressure immediately before the apnea.

Claims

1. A method for the administration of CPAP therapy comprising the steps of:

supplying breathable gas to a patient'"'"'s airway at a treatment pressure;

determining a measure of respiratory airflow;

determining the onset of an apnea from a reduction in the measure of respiratory airflow below a threshold and, in response to the onset of an apnea, increasing the treatment pressure by an amount which is a decreasing function of the treatment pressure immediately before the apnea onset; and

decreasing the pressure following a time interval during which there was no apnea.

4. A method as claimed in claim 1, 2 or 3 wherein the increase in treatment pressure is zero if the treatment pressure before the apnea exceeded a pressure threshold.

5. A method as claimed in claim 4 wherein the increase in pressure below the pressure threshold is an increasing function of the duration of the apnea, multiplied by the difference between the pressure threshold and the current treatment pressure.

6. A method as claimed in claim 5 wherein said increasing function of apnea duration is a linear function of apnea duration.

7. A method as claimed in claim 4 wherein the pressure threshold is 10 cmH₂O.

8. A method as claimed in claim 1, 2 or 3 wherein the occurrence of an apnea is determined by the steps of:

calculating the RMS respiratory airflow over a short time interval;

calculating the RMS respiratory airflow over a longer time interval; and

determining the onset of an apnea if the RMS respiratory airflow over said short time interval is less than a predetermined fraction of the RMS respiratory airflow over said longer time interval.

9. A method as claimed in claim 1, 2 or 3 wherein in the continued absence of apneas the treatment pressure is gradually reduced towards an initial treatment pressure.

10. A method as claimed in claim 1, 2 or 3 comprising the further steps of:

in the absence of an apnea, determining the presence of a partial obstruction; and

if a partial obstruction is present, increasing the treatment pressure.

11. A method as claimed in claim 9 wherein the presence of a partial obstruction is determined from either (a) the shape of the patient'"'"'s inspiratory flow vs time curve, or (b) the presence of snoring, or (c) both.

12. A method as claimed in claim 1, 2 or 3 comprising the further steps of:

if an apnea is occurring, determining whether the patient'"'"'s airway is patent during the apnea; and

if the airway is patent, not increasing the treatment pressure.

13. A method as claimed in claim 12 wherein the patency of the airway is determined by the steps of:

modulating the treatment pressure at a known frequency;

measuring the component of the respiratory airflow at the modulation frequency;

calculating the conductance of the airway as the ratio of the amplitude of said component of the respiratory airflow to the amplitude of the mask pressure modulation; and

determining that the airway is patent if the conductance exceeds a conductance threshold.

2. A method for the administration of CPAP therapy comprising the steps of:

supplying breathable gas to a patient'"'"'s airway at a treatment pressure;

determining a measure of respiratory airflow;

determining the occurrence of an apnea from a reduction in the measure of respiratory airflow below a threshold and, in response to the presence of an apnea, (i) determining the duration of the apnea, and (ii) increasing the treatment pressure by an amount which is an increasing function of the duration of the apnea; and

decreasing the pressure following a time interval during which there was no apnea.

3. A method for the administration of CPAP therapy comprising the steps of:

supplying breathable gas to a patient'"'"'s airway at a treatment pressure;

determining a measure of respiratory airflow;

determining the occurrence of an apnea from a reduction in the measure of respiratory airflow below a threshold and, in response to the presence of an apnea, (i) determining the duration of the apnea; and

(ii) increasing the treatment pressure by an amount which is an increasing function of the duration of the apnea and a decreasing function of the treatment pressure immediately before the apnea; and

decreasing the pressure following a time interval ring which there was no apnea.

14. CPAP treatment apparatus comprising:

a controllable flow generator operable to provide breathable gas at a pressure elevated above atmospheric;

a gas delivery tube coupled to said flow generator;

a patient mask coupled to said gas delivery tube to receive breathable gas from said flow generator and to provide said gas, at a desired treatment pressure, to a patient'"'"'s airway;

a controller operable to receive an input signal and to control the magnitude of the treatment pressure provided by said flow generator; and

sensor means to sense patient respiratory airflow and to generate an input signal to said controller;

said controller being programmed to determine the onset of an apnea from a reduction in said respiratory airflow below a threshold, in response to the onset of an apnea to cause said flow generator to increase the treatment pressure by an amount which is a decreasing function of the treatment pressure immediately prior to said apnea, and to decrease the pressure following a time interval during which there was no apnea.

17. Apparatus as claimed in claim 14, 25 or 26 wherein the increase in treatment pressure is zero if the treatment pressure before the apnea exceeded a pressure threshold.

18. Apparatus as claimed in claim 17 wherein the increase in pressure below the pressure threshold is an increasing function of the duration of the apnea, multiplied by the difference between the pressure threshold and the current treatment pressure.

19. Apparatus as claimed in claim 18 wherein said increasing function of apnea duration is a linear function of apnea duration.

20. Apparatus as claimed in claim 17 wherein the pressure threshold is 10 cmH₂O.

21. Apparatus as claimed in claim 14, 15 or 16 wherein said controller determines the occurrence of an apnea by:

calculating the RMS respiratory airflow over a short time interval;

calculating the RMS respiratory airflow over a longer time interval; and

determining the onset of an apnea if the RMS respiratory airflow over said short time interval is less than a predetermined fraction of the RMS respiratory airflow over said longer time interval.

22. Apparatus as claimed in claim 14, 15 or 16 wherein said controller is further operable to cause a gradual reduction in the treatment pressure towards an initial treatment pressure in the absence of an apnea.

23. Apparatus as claimed in claim 14, 15 or 16 wherein said controller is further operable, in the absence of an apnea, to determine the presence of a partial obstruction;

and if a partial obstruction is present, to increase the treatment pressure.

24. Apparatus as claimed in claim 23 wherein the presence of a partial obstruction is determined from either (a) the shape of the patient'"'"'s inspiratory flow vs time curve, or (b) the presence of snoring, or (c) both.

25. Apparatus as claimed in claim 14, 15 or 16 wherein said controller is operable, if an apnea is occurring, to determine whether the patient'"'"'s airway is patent during the apnea;

and, if the airway is patent, to set the increase in treatment pressure to zero.

26. Apparatus as claimed in claim 25 wherein said controller determines the patency of the airway by:

modulating the treatment pressure at a known frequency;

measuring the component of the respiratory airflow at the modulation frequency;

calculating the conductance of the airway as the ratio of the amplitude of said component of the respiratory airflow to the amplitude of the mask pressure modulation; and

determining that the airway is patent if the conductance exceeds a conductance threshold.

15. CPAP treatment apparatus comprising:

a controllable flow generator operable to provide breathable gas at a pressure elevated above atmospheric;

a gas delivery tube coupled to said flow generator;

a patient mask coupled to said gas delivery tube to receive breathable gas from said flow generator and to provide said gas, at a desired treatment pressure, to a patient'"'"'s airway;

a controller operable to receive an input signal and to control the magnitude of the treatment pressure provided by said flow generator; and

sensor means to sense patient respiratory airflow and to generate a signal input to said controller;

said controller being programmed to determine the occurrence of an apnea from a reduction in said respiratory airflow below a threshold, in response to the presence of an apnea to determine the duration of said apnea and to cause said flow generator to increase the treatment pressure by an amount which is an increasing function of said apnea duration, and to decrease the pressure following a time interval during which there was no apnea.

16. CPAP treatment apparatus comprising:

a controllable flow generator operable to provide breathable gas at a pressure elevated above atmospheric;

a gas delivery tube coupled to said flow generator;

a patient mask coupled to said gas delivery tube to receive breathable gas from said flow generator and to provide said gas, at a desired treatment pressure, to a patient'"'"'s airway;

a controller operable to receive an input signal and to control the magnitude of the treatment pressure provided by said flow generator; and

sensor means to sense patient respiratory airflow and to generate a signal input to said controller;

said controller being programmed to determine the occurrence of an apnea from a reduction in said respiratory airflow below a threshold, in response to the presence of an apnea to determine the duration of said apnea and to cause said flow generator to increase the treatment pressure by an amount which is an increasing function of said apnea duration and a decreasing function of the treatment pressure immediately prior to said apnea, and to decrease the pressure following a time interval during which there was no apnea.

27. CPAP treatment apparatus comprising:

a controllable source of breathable gas to be provided to a patient at a treatment pressure elevated above atmospheric; and

a controller operable to receive input signals representing patient respiratory airflow, and to control the magnitude of the treatment pressure provided by said source of breathable gas;

said controller being programmed to determine the onset of an apnea from a reduction in said respiratory airflow below a threshold, in response to the onset of an apnea to cause said flow generator to increase the treatment pressure by an amount which is a decreasing function of the treatment pressure immediately prior to said apnea, and to decrease the pressure following a time interval during which there was no apnea.

30. Apparatus as claimed in claim 27, 28 or 29 wherein the increase in treatment pressure is zero if the treatment pressure before the apnea exceeded a pressure threshold.

31. Apparatus as claimed in claim 30 wherein the increase in pressure below the pressure threshold is an increasing function of the duration of the apnea, multiplied by the difference between the pressure threshold and the current treatment pressure.

32. Apparatus as claimed in claim 31 wherein said increasing function of apnea duration is a linear function of apnea duration.

33. Apparatus as claimed in claim 31 wherein said increasing function of apnea duration is zero for zero apnea duration, and exponentially approaches an upper limit as apnea duration increases indefinitely.

34. Apparatus as claimed in claim 30 wherein the pressure threshold is 10 cmH₂O.

35. Apparatus as claimed in claim 27, 28 or 29 wherein said controller determines the occurrence of an apnea by:

calculating the RMS respiratory airflow over a short time interval;

calculating the RMS respiratory airflow over a longer time interval; and

determining the onset of an apnea if the RMS respiratory airflow over said short time interval is less than a predetermined fraction of the RMS respiratory airflow over said longer time interval.

36. Apparatus as claimed in claim 27, 28 or 29 wherein in the continued absence of apneas the treatment pressure is gradually reduced towards an initial treatment pressure.

37. Apparatus as claimed in claim 27, 28 or 29 wherein said controller is further operable, in the absence of an apnea, to determine the presence of a partial obstruction;

and if a partial obstruction is present, to increase the treatment pressure.

38. Apparatus as claimed in claim 37 wherein the presence of a partial obstruction is determined from either (a) the shape of the patient'"'"'s inspiratory flow vs time curve, or (b) the presence of snoring, or (c) both.

39. Apparatus as claimed in claim 27, 28 or 29 wherein said controller is operable, if an apnea is occurring, to determine whether the patient'"'"'s airway is patent during the apnea;

and, if the airway is patent, to set the increase in treatment pressure to zero.

40. Apparatus as claimed in claim 37 wherein said controller determines the patency of the airway by:

modulating the treatment pressure at a known frequency;

measuring the component of the respiratory airflow at said modulation frequency;

calculating the conductance of the airway as the ratio of the amplitude of said component of the respiratory airflow to the amplitude of the mask pressure modulation; and

determining that the airway is patent if the conductance exceeds a conductance threshold.

28. CPAP treatment apparatus comprising:

a controllable source of breathable gas to be provided to a patient at a treatment pressure elevated above atmospheric; and

a controller operable to receive input signals representing patient respiratory airflow, and to control the magnitude of the treatment pressure provided by said source of breathable gas;

said controller being programmed to determine the occurrence of an apnea from a reduction in said respiratory airflow below a threshold, in response to the presence of an apnea to determine the duration of said apnea and to cause said flow generator to increase the treatment pressure by an amount which is an increasing function of said apnea duration, and to decrease the pressure following a time interval during which there was no apnea.

29. CPAP treatment apparatus comprising:

a controllable source of breathable gas to be provided to a patient at a treatment pressure elevated above atmospheric; and

a controller operable to receive input signals representing patient respiratory airflow, and to control the magnitude of the treatment pressure provided by said source of breathable gas;

said controller being programmed to determine the occurrence of an apnea from a reduction in said respiratory airflow below a threshold, in response to the presence of an apnea to determine the duration of said apnea and to cause said flow generator to increase the treatment pressure by an amount which is an increasing function of said apnea duration and a decreasing function of the treatment pressure immediately prior to said apnea, and to decrease the pressure following a time interval during which there was no apnea.