Methods of producing an assembly for use in a monitoring device
First Claim
1. A method of producing an assembly for use in a monitoring device for monitoring a chemical signal present in a subject, said method comprising:
- providing (a) an ionically conductive material comprising first and second faces, said first face comprising a chemical signal target area, the ionically conductive material comprising water and an electrolyte; and
(b) a mask characterized by being substantially impermeable to a chemical signal; and
positioning said mask on the second face of the ionically conductive material opposite the first face such that chemical signal transported through a plane of the mask, through the ionically conductive material, and toward the chemical signal target area is substantially only that chemical signal transported in a direction substantially perpendicular to the chemical signal target area, thereby resulting in production of said assembly.
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Accused Products
Abstract
A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.
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Citations
21 Claims
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1. A method of producing an assembly for use in a monitoring device for monitoring a chemical signal present in a subject, said method comprising:
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providing (a) an ionically conductive material comprising first and second faces, said first face comprising a chemical signal target area, the ionically conductive material comprising water and an electrolyte; and
(b) a mask characterized by being substantially impermeable to a chemical signal; and
positioning said mask on the second face of the ionically conductive material opposite the first face such that chemical signal transported through a plane of the mask, through the ionically conductive material, and toward the chemical signal target area is substantially only that chemical signal transported in a direction substantially perpendicular to the chemical signal target area, thereby resulting in production of said assembly. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of producing an assembly for use in a monitoring device for monitoring glucose present in a subject, said method comprising:
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providing (a) a hydrogel, comprising first and second faces, said first face comprising a chemical signal target area, the hydrogel comprising (i) a hydrophilic compound which forms a gel in water, wherein the hydrophilic compound is present in an amount of about 4% or more by weight based on the total weight of the hydrogel, (ii) a chloride salt, and (iii) glucose oxidase, (b) a mask characterized by being substantially impermeable to glucose, and (c) a working electrode having a catalytic surface, wherein the chemical signal target area is an area of the hydrogel face that contacts the catalytic surface of the working electrode during glucose monitoring; and
positioning (a) said mark on the second face of the ionically conductive material opposite the first face such that glucose transported through a plane of the mask, through the ionically conductive material, and toward the chemical signal target area is substantially only that glucose transported in a direction substantially perpendicular to the chemical signal target area, and (b) said catalytic surface that it is aligned with the chemical signal target area of the hydrogel, thereby resulting in production of said assembly. - View Dependent Claims (18, 19, 20, 21)
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Specification