Magnetic resonance imaging method

• US 6,370,415 B1
• Filed: 04/10/1998
• Issued: 04/09/2002
• Est. Priority Date: 04/10/1998
• Status: Expired due to Fees

• Current Assignee: Polarean, Inc. (Polarean Imaging Plc)
• Original Assignee: Medi-Physics Incorporated (General Electric Company)
• Inventors: Ebert, Michael, Lauer, Lars, Surkau, Reinhard, Deninger, Anselm, Schreiber, Wolfgang, Heil, Werner, Grossmann, Tino, Weiler, Norbert, Roberts, Timothy P. L., Eberle, Balthasar, Kauczor, Hans-Ulrich, Markstaller, Klaus
• Primary Examiner(s): Isabella, David J.
• Application Number:
  US09/057,979
• Time in Patent Office: 1,460 Days
• Field of Search: 600/407, 600/410, 600/411, 600/420, 600/437, 600/439, 424/9.3, 424/9.37, 436/173
• US Class Current: 600/410
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oxygen uptake from the alveolar space in said at least one region of interest.

Claims

1. A method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating any of the following:

a qualitative value, qualitative image, quantitative value and quantitative image indicative of the oxygen concentration in the said at least one region of interest.

2. A method as claimed in claim 1 wherein said hyperpolarized agent comprises ³He.

3. A method as claimed in claim 1 wherein detection of said magnetic resonance signal is effected during a period of at least 1 second during which there is substantially no gas flow into or out of the lungs.

4. A method as claimed in claim 1 wherein said regions of interest comprise regions of alveolar space.

5. A method as claimed in claim 1 wherein a spatial mr image is also generated.

6. A method as claimed in claim 5 wherein said spatial image is constructed from magnetic resonance signals from said hyperpolarized agent.

7. A method as claimed in claim 5 wherein a further magnetic resonance imaging agent is administered into the vasculature or lungs of said subject.

8. A method as claimed in claim 7 wherein a spatial image is constructed from magnetic resonance signals from magnetic resonance active nuclei in said further magnetic resonance imaging agent.

9. A method as claimed in claim 8 wherein said further agent comprises a 19F fluorocarbon.

10. A method as claimed in claim 1 wherein said magnetic resonance signals are detected in at least two different types of magnetic resonance imaging sequence.

11. A method as claimed in claim 10 wherein said types of sequence differ in the intensity of the magnetic resonance signal stimulating radiation.

12. A method as claimed in claim 10 wherein said types of sequence differ in the sequence timing.

13. A method as claimed in claim 10 wherein said types of sequence are interleaved.

14. A method as claimed in claim 1 wherein magnetic resonance signal detection is effected in an imaging sequence with an image acquisition time of less than 2 seconds.

15. A method as claimed in claim 1 wherein magnetic resonance signal detection is effected in an imaging sequence involving imposition of a flip angle of less than 7°

.

16. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus.

17. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus of volume 1 to 1000 ml.

18. A method as claimed in claim 1 wherein a mr imager with a primary field strength in the range of 0.05 to 3.5 T is used to defeat said magnetic resonance signal.

19. A method as claimed in claim 1 wherein said hyperpolarized agent comprises ¹²⁹Xe.

20. A method as claimed in claim 1 wherein said method also generates the time dependency of said concentration.

21. A method as claimed in claim 20 wherein a temporal mr image is also generated.

22. A method as claimed in claim 21 wherein said temporal image is constructed from magnetic resonance signals from said hyperpolarized agent.