Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients

• US 6,371,922 B1
• Filed: 04/07/2000
• Issued: 04/16/2002
• Est. Priority Date: 04/07/2000
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kadhiresan, Veerichetty A., Baumann, Lawrence S.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/545,362
• Time in Patent Office: 739 Days
• Field of Search: 600/485, 600/481, 600/500, 600/505, 600/526, 607/17, 607/23
• US Class Current: 600/485
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A method and apparatus for determining the baroreflex sensitivity in a chronic heart failure patient and a method for chronic heart therapy evaluation. The method including providing a series of pacing stimuli to the heart of a chronic heart failure patient and measuring the change in pulse pressure and the change in cycle length incident to each pacing series. The changes being plotted to produce a line indicative of baroreflex sensitivity. The apparatus including a pacemaker having sensors for monitoring both cycle length and pulse pressure wherein the sensors may be integral or separate from the pacemaker. The method for evaluating chronic heart failure therapies including administering a series of therapies and evaluating each therapy based on the resultant increase of the patient'"'"'s baroreflex sensitivity.

Claims

1. A method for measuring baroreflex sensitivity and adjusting patient therapy based on measured values, comprising:

pacing a heart for a plurality of paced heart beats, wherein the plurality of paced beats comprise a pacing series and each of the pacing series is followed by a plurality of intrinsic heart beats, wherein the plurality of intrinsic heart beats comprise an intrinsic series

measuring a change in pulse pressure during the pacing series;

measuring a change in intrinsic cycle length resulting from the change in pulse pressure during the pacing series;

calculating baroreflex sensitivity from the change in pulse pressure measurements and the change in intrinsic cycle length measurements after a plurality of pacing series, and

adjusting a therapy to maximize the calculated baroreflex sensitivity.

2. A method, as in claim 1, wherein adjusting patient therapy comprises changing at least one of AV delay, right ventricle stimulation, left ventricle stimulation, and atrial sensing of a pacemaker implanted in the patient.

3. A method, as in claim 1, wherein measuring the change in pulse pressure includes determining an intrinsic pulse pressure at the patient'"'"'s quiet time.

4. A method, as in claim 3, wherein measuring a change in pulse pressure includes using a sensor selected from the group consisting of a Millar pressure transducer, an RV pressure transducer, a LV pressure transducer, an RV impedance sensor, a LV impedance sensor, an aortic cuff, an accelerometer, an echo catheter, a Doppler echo device, an external pressure cuff, an external impedance sensor, a radial tonometer, and a plethysmogram sensor.

5. A method, as in claim 3, wherein measuring a change in pulse pressure includes using a method selected from the group consisting of Doppler echo, radial tonometry, thermodilution, dye dilution, MUGA, plethysmography, Fick method, acetylene rebreathing technique and carbon dioxide rebreathing technique.

6. A method, as in claim 1, wherein the step of measuring a change in intrinsic cycle length includes using one of an electrocardiographic sensor, an atrial electrographic sensor and a ventricular electrographic sensor.

7. A method for measuring baroreflex sensitivity and adjusting patient therapy based on measured values, comprising:

a step for pacing a heart for a plurality of paced heart beats, wherein the plurality of paced beats comprise a pacing series and each of the pacing series are followed by a plurality of intrinsic heart beats, wherein the plurality of intrinsic heart beats comprise an intrinsic series;

a step for determining a change in pulse pressure during the pacing series;

a step for determining a change in intrinsic cycle length resulting from the change in pulse pressure;

a step for determining baroreflex sensitivity based on the change of cycle length divided by the change in pulse pressure, and

a step for selecting a therapy that optimizes the determined baroreflex sensitivity.