Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
First Claim
1. A pharmaceutical composition comprising an edible substrate having micronized drug substance with a particle size of 1-100 μ
- m deposited on the surface of the substrate by electrostatic dry powder deposition, and a film coating on the substrate and drug substance consisting essentially of polyethylene glycol, wherein the film coating is applied by;
(a) coating the substrate in place by electrostatic dry powder deposition with dry micronized polyethylene glycol having a molecular weight in the range of 1,000 to 20,000 and having a particle size of 1-100 μ
m, and (b) melting the dry polyethylene glycol coating and allowing it to cool whereupon a protective coating is formed.
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Accused Products
Abstract
The invention relates to a substrate coating for the electrostatic deposition of dry powder medicaments for use in the manufacture of pharmaceutical dosage forms comprising micronized polyethylene glycol (PEG), with A molecular weight in the range of 1,000 to 20,000, and having a particle size of 1-100 μm. The invention also relates to pharmaceutical compositions having such a substrate coating, and processes for manufacturing such pharmaceutical compositions. The invention also relates to the technology of reversing negative charge of medicaments so that they can be electrostatically deposited on a negatively charged substrate.
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Citations
8 Claims
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1. A pharmaceutical composition comprising an edible substrate having micronized drug substance with a particle size of 1-100 μ
- m deposited on the surface of the substrate by electrostatic dry powder deposition, and a film coating on the substrate and drug substance consisting essentially of polyethylene glycol, wherein the film coating is applied by;
(a) coating the substrate in place by electrostatic dry powder deposition with dry micronized polyethylene glycol having a molecular weight in the range of 1,000 to 20,000 and having a particle size of 1-100 μ
m, and(b) melting the dry polyethylene glycol coating and allowing it to cool whereupon a protective coating is formed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- m deposited on the surface of the substrate by electrostatic dry powder deposition, and a film coating on the substrate and drug substance consisting essentially of polyethylene glycol, wherein the film coating is applied by;
Specification