Dehydrated hydrogels

• US 6,372,248 B1
• Filed: 05/30/1997
• Issued: 04/16/2002
• Est. Priority Date: 10/28/1994
• Status: Expired due to Fees

• Current Assignee: Innovative Technologies, Incorporated (Valmont Industries Incorporated)
• Original Assignee: Innovative Technologies, Incorporated (Valmont Industries Incorporated)
• Inventors: Qin, Yimin, Gilding, Denis Keith
• Primary Examiner(s): Metzmaier, Daniel S.
• Application Number:
  US08/809,685
• Time in Patent Office: 1,782 Days
• Field of Search: 252/194, 252/315.1, 252/315.3, 252/315.4, 602/45, 602/49, 602/56, 602/900, 428/403, 428/407, 424/445, 424/485, 424/488, 424/493, 424/494, 424/496, 424/443, 424/78.06, 424/449, 424/486, 424/487, 524/916, 260/DIG.31
• US Class Current: 424/443
• CPC Class Codes: A61L 26/0023 Polysaccharides
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof

Abstract

A dehydrated hydrogel incorporating a plasticiser and fibers which have provided cations for cross-linking the dehydrated hydrogel.

Claims

1. A water absorbable composition containing less than 20% by weight of water that is suitable for use in the treatment of wounds, comprising a dehydrated hydrogel having a cross-linked macro-molecular network, including a precursor polymer, integrated fibres that have donated cations for cross-linking the precursor polymer to form the cross-linked macro-molecular network, and a plasticizer.

2. A composition as claimed in claim 1 in the form of a film.

3. A composition as claimed in claim 2 wherein the film has a thickness of 20 microns to 1 mm.

4. A composition as claimed in claim 1 comprising 15 to 40% by weight of fibres forming the dehydrated hydrogel, 10 to 35% by weight of polymer forming the dehydrated hydrogel and 5 to 75% by weight of plasticiser, the percentages being based on the total weight of fibres and polymer forming the dehydrated hydrogel and of plasticiser.

5. A composition as claimed in claim 4 wherein the fibres and polymer forming the dehydrated hydrogel together provide about 40-60% by weight on the same weight basis as defined in claim 4.

6. A composition as claimed in claim 1 wherein the amount of fibres exceeds the amount of polymer forming the dehydrated hydrogel.

7. A composition as claimed in claim 6 wherein the weight ratio of fibres:

polymer forming the dehydrated hydrogel is 1.5-3;

1.

8. A composition as claimed in claim 1 wherein the fibres have a length of 1 to 80 mm.

9. A composition as claimed in claim 1 wherein the fibres have a thickness of 10 to 50 microns.

10. A composition as claimed in claim 1 wherein the plasticiser is glycerol, polyethylene glycol, sorbitol or a PEO/PPO polymer.

11. A composition as claimed in claim 1 in which said dehydrated hydrogel in a dehydrated form incorporates acemannan.

12. The composition of claim 11 wherein said dehydrated hydrogel is derived from polymers selected from the group consisting of sodium alginate, sodium carboxymethyl cellulose, sodium pectinate, sodium O-carboxymethyl chitosan (OCC), sodium N,O-carboxymethyl chitosan (NOCC), sodium polyacrylate, and naturally occurring gums and synthetic polymers containing pendant carboxylic acid groups.

13. The compositions of claim 1 wherein said dehydrated hydrogel is derived from sodium alginate and said fibres are calcium alginate fibres.

14. A method of producing a water absorbable composition containing less than 20% by weight of water that is suitable for use in the treatment of wounds, comprising

(i) dispersing fibres into an aqueous solution of a hydrogel precursor material incorporating plasticiser, said fibres being capable of donating cations to cross-link said hydrogel precursor material to form a hydrogel;

(ii) effecting formation of a hydrogel by cross-linking of the hydrogel precursor material by cations donated from said fibres so as to form a hydrogel product containing said hydrogel and product fibres derived from the fibres that have donated cations for effecting cross-linking; and

(iii) evaporating water from said hydrogel product to produce said composition in the form of a dehydrated hydrogel containing said product fibres.

15. A method as claimed in claim 14 wherein the hydrogel precursor material is selected from the group consisting of sodium alginate, sodium carboxymethyl cellulose, sodium pectinate, sodium O-carboxymethyl chitosan (OCC), sodium N,O-carboxymethyl chitosan (NOCC), sodium polyacrylate, and naturally occurring gums and synthetic polymers containing pendant carboxylic acid groups.

16. A method as claimed in claim 14 wherein the fibres contain Ca²⁺, Zn²⁺ or cations which also act as enzyme cofactors.

17. A method as claimed in claim 16 wherein the fibres are calcium alginate fibres.

18. A method as claimed in claim 17 wherein the hydrogel precursor material is sodium alginate.

19. A method of producing a water absorbable composition containing less than 20% by weight of water that is suitable for use in the treatment of wounds, comprising

(i) dispersing calcium alginate fibres into an aqueous solution of sodium alginate incorporating plasticiser, said calcium alginate fibres being capable of donating calcium ions to cross-link said sodium alginate to form a hydrogel;

(ii) effecting formation of a hydrogel by cross-linking of the sodium alginate by calcium ions donated from said fibres so as to form a hydrogel product containing said hydrogel and product fibres derived from said calcium alginate fibres cations that have donated cations for effecting cross-linking; and

(iii) evaporating water from said hydrogel product to produce said composition in the form of a dehydrated hydrogel containing said product fibres.

20. A method of producing a water absorbable composition containing less than 20% by weight of water that is suitable for use in the treatment of wounds, comprising

(i) dispersing fibres into an aqueous solution of a hydrogel precursor material incorporating plasticiser, said fibres being capable of donating cations to cross-link said hydrogel precursor material to form a hydrogel;

(ii) casting the composition resulting from step (i) into a form for producing a film in step (iii)

(iii) effecting formation of a hydrogel by cross-linking of the hydrogel precursor material by cations donated from said fibres so as to form a film of a hydrogel product containing said hydrogel and product fibres derived from the fibres that donated cations for effecting cross-linking; and

(iv) evaporating water from said hydrogel product to produce a film of said composition in the form of a dehydrated hydrogel containing said product fibres, said film being capable on absorption of wound exudate of swelling in the thickness dimension without substantial swelling in the other two dimensions.

21. A method as claimed in claim 20 wherein the hydrogel precursor material is sodium alginate and the fibres are calcium alginate fibres.

22. A water absorbable composition suitable for use in the treatment of wounds, said composition containing less than 20% moisture and being in the form of a film, the composition comprising a dehydrated hydrogel having a cross-linked macromolecular network, including a precursor polymer, integrated product fibres derived from fibres that have donated cations for cross-linking the precursor polymer to form the cross-linked macromolecular network, and a plasticiser, said film being capable of an absorption of wound exudate of swelling in the thickness dimension without substantial swelling in the other two dimensions.

23. A composition as claimed in claim 22 wherein the precursor polymer is sodium alginate and the product fibres are derived from calcium alginate fibres.