Anti-inflammatory compounds
First Claim
Patent Images
1. A compound having the formula:
-
wherein X is H, H;
R1 is hydrogen or is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- and unsubstituted thiophene, furan, pyrrole, or pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino;
or sulfone; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.
1 Assignment
0 Petitions
Accused Products
Abstract
This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
2 Citations
93 Claims
-
1. A compound having the formula:
-
wherein X is H, H;
R1 is hydrogen or is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- and unsubstituted thiophene, furan, pyrrole, or pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino;
or sulfone; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 15, 65)
-
-
13. A compound having the formula:
-
wherein X is H, H;
R1 is hydrogen or is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- and unsubstituted thiophene, furan, pyrrole, or pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino;
or sulfone;
wherein R4 is heteroaromatic lower alkyl. - View Dependent Claims (14)
-
-
16. A compound having the formula:
-
wherein X is H, H;
R1 is selected from the group consisting of hydrogen and halogen group;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, and pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
-
27. A compound having the formula:
-
wherein X is H, H;
R1 is selected from the group consisting of hydrogen and halogen group;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, and pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone;
wherein R4 is heteroaromatic lower alkyl. - View Dependent Claims (28)
-
-
29. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (30, 31, 32, 35)
-
-
33. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone;
wherein R4 is heteroaromatic lower alkyl. - View Dependent Claims (34)
-
-
36. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is selected from hydrogen and lower alkyl;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (37, 38, 39, 42)
-
-
40. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is selected from hydrogen and lower alkyl;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone;
wherein R4 is heteroaromatic lower alkyl. - View Dependent Claims (41)
-
-
43. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is selected from hydrogen and lower alkyl;
Z is carbonyl; and
R4 is phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, benzothiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is chosen from substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (44, 46, 52, 56, 58, 60, 61)
-
-
45. A compound having the formula:
-
wherein X is H, H;
Y is H, H;
R1 is selected from hydrogen and halogen;
R2 is selected from phenyl and halophenyl;
R3 is selected from hydrogen and lower alkyl;
Z is carbonyl;
wherein R4 is heteroaromatic lower alkyl. - View Dependent Claims (49, 50, 53, 54, 59)
-
-
47. An antiinflammatory composition comprising a pharmaceutically acceptable carrier and an antiinflammatory-effective amount of a compound having the formula:
-
wherein X H, H;
R1 is hydrogen or is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, lower alkylenoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, and pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone; and
R4 is straight- or branched-chain alkyl having from 2 to 12 carbon atoms;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrile;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, pyridine, and a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine.- View Dependent Claims (48, 51, 55, 57)
-
-
62. A method of making a compound having the formula:
-
wherein X is H, H;
R1 is hydrogen or is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrite;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, or pyridine;
Y is H, H;
R3 is chosen from the group consisting of hydrogen;
alkyl;
cycloalkyl;
alkenyl;
alkynyl;
phenyl in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido and nitrite;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino; and
sulfone; and
R4 is straight- or branched-chain alkyl having from 2 to 12 carbon atoms;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrite;
a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, pyridine, or a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole and pyridine;
comprising the steps of (II) reacting R2CH2CN with a compound having the formula (11) in the presence of n-butyl lithium;
to obtain a compound having the formula (III) (2) reacting said compound of formula (III) with lithium aluminum hydride to form a compound of formula (IV);
and(3) reacting said compound of formula (IV) with compound selected from the group consisting of;
(a) sodium acetate and R4COCl;
(b) CDl and R4CO2H;
(c) EtN═
C═
N(CH2)3NMe2HCl;
(d) R4CO2H;
(e) ClCO2R4;
(f) ClC═
O(NHR4); and
(g) R4SO2Cl to obtain a compound of formula (I).
-
-
63. A method of making a compound having the formula:
-
wherein X is H,H;
R1 is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, or pyridine;
wherein Y is H, H;
R3 is hydrogen;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino;
or sulfone; and
R4 is straight- or branched-chain alkyl having from 2 to 12 carbon atoms;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
a heteroaromatic ring such as substituted- or unsubstituted thiophene, furan, pyrrole, pyridine, or a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is chosen from substituted- or unsubstituted thiophene, furan, pyrrole or pyridine;
comprising the steps of (1) reacting DiBAL with a compound having the formula (VII);
to obtain a compound having the formula (VIII) (2) reacting said compound of formula (VIII) with Rink resin to give a resin-bound compound of formula (IX);
(3) reacting said compound of formula (IX) with sodium triacetoxyborohydride to form a compound of formula (X);
(4) reacting said compound of formula (X) with R4CO2H in the presence of HATU and DIEA followed by treatment with TFA to form a compound of formula (I).
-
-
64. A method of making a compound having the formula:
-
wherein X is H,H;
R1 is from one to three substituent groups each selected from the group consisting of lower alkyl (C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
R2 is a phenyl group in which said phenyl group is substituted with hydrogen or from one to three substituent groups each selected from the group consisting of lower alkyl(C2-C6), lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile, a heteroaromatic ring selected from the group consisting of substituted- or unsubstituted thiophene, furan, pyrrole, or pyridine;
wherein Y is H, H;
R3 is hydrogen;
Z is selected from the group consisting of carbonyl;
carboxy;
carbonylamino;
or sulfone; and
R4 is straight- or branched-chain alkyl having from 2 to 12 carbon atoms;
phenylloweralkyl in which said phenyl group is substituted with hydrogen or with one to three substituent groups each selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halo, carboxy, carboalkoxy, amino, amido, sulfonamido or nitrile;
a heteroaromatic ring such as substituted- or unsubstituted thiophene, furan, pyrrole, pyridine, or a heteroaromatic ring connected by a lower alkyl chain wherein said heteroaromatic ring is chosen from substituted- or unsubstituted thiophene, furan, pyrrole or pyridine;
comprising the steps of (1) reacting said compound of formula (XII) with Merrifield resin to form a compound of formula (XIII);
to obtain a compound of formula XIII (2) reacting said compound of formula XIII with a compound of formula XIV and an appropriate acid R4CO2H to obtain a compound of formula (I).
-
-
66. A compound having the name N-(2-thiophene)acetyl-2,3,3-triphenylpropylamine.
-
67. A compound having the name N-(5-methylthiophene)acetyl-2-phenyl-3,3-bis(4-fluorophenyl)propylamine.
-
68. A compound having the name N-(3-indolyl) acetyl-2,3,3-triphenylpropylamine.
-
69. A compound having the name N-(4-n-butoxyphenyi)acetyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
70. A compound having the name N-(2,4-difluorophenyl)acetyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
71. A compound having the name N-(2-thiophene)carbonyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
72. A compound having the name N-3-cyanophenyl)acetyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
73. A compound according having the name N-(2,4-difluorophenyl)carbonyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
74. A compound having the name N-(4-fluorophenyl)acetyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
75. A compound having the name N-(4,5-dichlorophenyl)carbonyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
-
76. A compound having the name N-(3-methylphenyl)acetyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
77. A compound having the name N-(phenyl)acetyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
78. A compound having the name N-(5-chloro-2-benzothiophene)acetyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
79. A compound having the name N-(2,4-difluorophenyl)carbonyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
80. A compound having the name N-(4-trifluoromethylphenyl)acetyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
81. A compound having the name N-(phenyl)acetyl-2-(4-trifluoromethylphenyl)-3,3-diphenylpropylamine.
-
82. A compound having the name N-(4-fluorophenyl)acetyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
83. A compound having the name N-(3,5-bis-tri fluorophenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
84. A compound having the name N-(4-chlorophenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
85. A compound having the name N-(3,4-dichlorophenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
86. A compound having the name N-(2-fluorophenyl)carbonyl-2-(4iodomethylphenyl)-3,3-diphenylpropylamine.
-
87. A compound having the name N-(2-fluorophenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
88. A compound having the name N-(4-fluorophenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
89. A compound having the name N-(4-trifluoromethylphenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
90. A compound having the name N-(3,5-bistrifluoromethylphenyl)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
91. A compound having the name N-(2-thiophene) carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
92. A compound having the name N-(5-methyl-2-thiophene)carbonyl-2-(4-iodomethylphenyl)-3,3-diphenylpropylamine.
-
93. A compound having the name N-(4-chlorophenyl)carbonyl-2-(3,4-methylenedioxyphenyl)-3,3-diphenylpropylamine.
Specification