Dental materials packaging and method of use

• US 6,372,816 B1
• Filed: 02/04/2000
• Issued: 04/16/2002
• Est. Priority Date: 06/25/1999
• Status: Expired due to Term

• Current Assignee: Dentsply Detrey Gmbh (Astrazeneca PLC)
• Original Assignee: Dentsply Detrey Gmbh (Astrazeneca PLC)
• Inventors: Pflug, Kai P., Wilner, Ralf, Walz, Uwe, Evers, Markus
• Primary Examiner(s): SZEKELY, PETER A
• Application Number:
  US09/498,004
• Time in Patent Office: 802 Days
• Field of Search: 523/116, 523/117, 523/118, 523/115, 526/281, 433/228.1, 206/63.5
• US Class Current: 523/116
• CPC Class Codes: A61C 2202/02 Packaging for volatile material
• CPC Class Codes: A61C 5/66 Capsules for filling material
• CPC Class Codes: B65D 2565/387 Materials used as gas barriers
• CPC Class Codes: Y02W 30/80 Packaging reuse or recycling, e.g. of multilayer packaging bio-packaging Y02W90/10

Abstract

The invention provides a storage stable dental composition comprising a volatile organic solvent and a polymerizable material enclosed by a package, which includes a closure, such as a cover or plug and a container made of a copolymer of a cycloolefin and an open chain olefin. In accordance with an embodiment of the invention is provided a stored packaged dental product by the process including: enclosing a dental composition in a package with at least a substantial portion of an injection molded thermoplastic copolymer of a cycloolefin and an open chain olefin, and storing the dental composition in the package for at least 1 week.

Claims

1. A storage stable packaged dental composition, comprising:

a package and a dental composition,

said dental composition being enclosed by said package,

said package comprising a container, said container comprising a copolymer of a cycloolefin and an open chain olefin, said container having a wall with an average thickness from about 0.4 mm to about 6 mm,

said dental composition, comprising a polymerizable material, and at least 10 percent by weight of volatile organic solvent, and at least 99 percent of said solvent remains in said dental composition in said container after storage at about 43°

C. for one week.

2. The storage stable packaged dental composition of claim 1 wherein said package further comprises a closure.

3. The storage stable packaged dental composition of claim 2 wherein said closure comprises a metal foil.

4. The storage stable packaged dental composition of claim 2 wherein said closure comprises a thermoplastic layer.

5. The storage stable packaged dental composition of claim 2 wherein said closure comprises a lacquer coating.

6. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is stored at about 23°

C. for at least one year and at least 80 percent of said volatile organic solvent remains in said package.

7. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is stored at about 23°

C. for at least two years and at least 90 percent of said volatile organic solvent remains in said package.

8. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is stored at about 23°

C. for at least two years and at least 95 percent of said volatile organic solvent remains in said package.

9. The storage stable packaged dental composition of claim 1 wherein said volatile organic solvent comprises acetone.

10. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 20 percent by weight acetone both before and after storage at about 23°

C. for two years and at least 95 percent of said volatile organic solvent remains in said package after said storage.

11. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 20 percent by weight acetone both before and after storage at about 23°

C. for one year and at least 90 percent of said acetone remains in said package after said storage.

12. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 40 percent by weight acetone both before and after storage at about 23°

C. for two years and at least 95 percent of said volatile organic solvent remains in said package after said storage.

13. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 40 percent by weight acetone both before and after storage at about 23°

C. for one year and at least 90 percent of said acetone remains in said package after said storage.

14. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 50 percent by weight acetone both before and after storage at about 23°

C. for two years and at least 95 percent of said volatile organic solvent remains in said package after said storage.

15. The storage stable packaged dental composition of claim 1 wherein said packaged dental composition is at least 50 percent by weight acetone both before and after storage at about 23°

C. for one year and at least 90 percent of said acetone remains in said package after said storage.

16. A storage stable packaged dental composition, comprising:

a package and a dental composition,

said dental composition being enclosed by said package,

said package comprising a container, said container comprising a copolymer of a cycloolefin and an open chain olefin,

said dental composition, comprising a volatile solvent and a polymerizable material,

said packaged dental composition being at least 10 percent by weight solvent, before storage at about 43°

C. for one week and at least 99 percent of said solvent remains in said dental composition in said package after said storage.

17. The storage stable packaged dental composition of claim 16 wherein said volatile solvent comprises acetone and at least 99.5 percent of said solvent remains in said package after said storage.

18. The storage stable packaged dental composition of claim 16 wherein at least 99.8 percent of said solvent remains in said package after said storage.

19. The storage stable packaged dental composition of claim 16 wherein said solvent is a volatile organic solvent and at least 99.9 percent of said solvent remains in said package after said storage.

20. A packed dental product, comprising:

a dental composition and

a package, said package comprising a container and a closure, said package substantially enclosing said dental composition, said dental composition comprising a volatile solvent, at least a portion of said container comprising a thermoplastic polymer comprising a copolymer of a cycloolefin and an open chain olefin and having a high permeability barrier capability for water and high chemical resistance,

whereby when said dental composition is stored at about 23°

C. in said package for at least two years and at least 99 percent of said volatile solvent remains in said dental composition in said package.

21. The product of claim 20 wherein said closure comprises a molded polymeric material or a polymeric film laminated to a foil.

22. The product of claim 20 wherein said container comprises injection molded polymeric material, said container has a notch and said container is readily broken at said notch, and said closure comprises injection molded polymeric material.

23. The product of claim 20 wherein said package has a longest dimension less than 4 cm.

24. The product of claim 20 wherein said container has a longest dimension less than 2 cm.

25. The product of claim 20 wherein said volatile solvent comprises acetone.

26. The product of claim 20 wherein said cover comprises a metal foil.

27. The product of claim 20 wherein said cover closure comprises a thermoplastic polymer comprising a copolymer of a cycloolefin and an olefin and having a high permeability barrier capability for water and high chemical resistance.

28. The product of claim 20 wherein said copolymer has a permeability to water of less than 0.07 (g)(mm/m²)(24 hours) at 23°

C. and 85% relative humidity.

29. The product of claim 20 wherein said copolymer has a permeability to water of less than 0.05 (g)(mm/m²)(24 hours) at 23°

C. and 85% relative humidity.

32. The product of claim 29 wherein said dental composition is a single unit dosage and said thermoplastic polymer has a high chemical resistance, a high penetration barrier capability for water, high penetration barrier capability for solvent and a high permeability barrier capability for water.

30. A stored packaged dental product by the process comprising:

enclosing a dental composition having at least one volatile component in a package, at least a substantial portion of said package comprising thermoplastic polymer having a high chemical resistance and a high permeability barrier capability for water, and

storing said dental composition in said package for at least two weeks at 37°

C. and after said two weeks at least 90 percent of said volatile component remains in said dental composition in said package.

36. The stored packaged dental product by the process of claim 30 wherein after said storing said dental composition bonds to dentin with a bond strength at least as high as said dental composition bonds to dentin before said storing.

31. A stored packaged dental product by the process comprising:

enclosing a dental adhesive composition comprising volatile solvent in a package, at least a substantial portion of said package comprising an injection molded thermoplastic copolymer of a cycloolefin and an open chain olefin, and effectively retaining said volatile solvent in said dental composition while storing said dental composition in said package for at least 1 week at about 23°

C.

33. The stored packaged dental product of claim 31 wherein

said solvent comprises a polar organic solvent, said copolymer of a cycloolefin and an open chain olefin has a high permeability barrier capability for water and high chemical resistance, and at least 90 percent of said polar organic solvent remains in said dental composition In said package while stored at about 23° C. for about two years.

34. The stored packaged dental product by the process of claim 31 wherein said dental composition comprises at least 10 percent by weight of said solvent, and at least 99 percent of said solvent remains in said dental composition in said package, after said storage.

35. The stored packaged dental product by the process of claim 31 wherein said dental composition comprises at least 15 percent by weight of said solvent, and at least 99.8 percent of said solvent remains in said dental composition in said package, after said storage.

37. The stored packaged dental product by the process of claim 31 wherein said dental composition bonds to dentin with effectively the same amount of bond strength before and after said storing.