Blend of ethylene and α-olefin copolymers obtained using a metallocene catalyst for fabricating medical films and tubings

• US 6,372,848 B1
• Filed: 10/10/2000
• Issued: 04/16/2002
• Est. Priority Date: 10/10/2000
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Warren, Joel, Yang, Tahua, Shang, Sherwin, Ding, Samuel, Ling, Michael T. K., Woo, Lecon
• Primary Examiner(s): Nutter, Nathan M.
• Application Number:
  US09/685,651
• Time in Patent Office: 553 Days
• Field of Search: 525/191, 525/240, 523/113, 602/41, 602/42, 602/48, 602/52, 604/6.16, 604/8, 604/19
• US Class Current: 525/191
• CPC Class Codes: A61L 29/049 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 2205/02 containing two or more polymers of the same C08L -group
• CPC Class Codes: C08L 23/04 Homopolymers or copolymers of ethene
• CPC Class Codes: C08L 23/0815 Copolymers of ethene with aliphatic 1-olefins
• CPC Class Codes: C08L 2314/06 Metallocene or single site catalysts
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof

Abstract

The present invention provides a polymer blend for fabricating medical products. The blend has a first ethylene and α-olefin copolymer obtained using a single-site catalyst present in an amount by weight of from about 0% to about 99% by weight of the blend and having a melt flow index from about 0.1 g/10 min to about 5 g/10 min, a second ethylene and α-olefin copolymer obtained using a single-site catalyst and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index from higher than about 5 g/10 min to about 20 g/10 min; and a third ethylene and α-olefin copolymer obtained using a single-site catalyst and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index greater than about 20 g/10 min.

Claims

1. A polymer blend for fabricating medical products comprising:

a first ethylene and α

-olefin copolymer obtained using a single-site catalyst present in an amount by weight of from about 0% to about 99% by weight of the blend and having a melt flow index from about 0.1 g/10 min to about 5 g/10 min;

a second ethylene and α

-olefin copolymer obtained using a single-site catalyst and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index from higher than about 5 g/10 min to about 20 g/10 min; and

a third ethylene and α

-olefin copolymer obtained using a single-site catalyst and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index greater than about 20 g/10 min.

2. The blend of claim 1 wherein the first, second hand third ethylene and α

-olefin copolymers are each present in an amount within the range of from about 5% to about 70% by weight of the blend.

3. The blend of claim 2 wherein the first, second and third ethylene and α

-olefin copolymers are each present in substantially equal quantities by weight of the blend.

4. The blend of claim 1 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 30,000 psi.

5. The blend of claim 1 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 20,000 psi.

6. The blend of claim 1 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 10,000 psi.

7. The blend of claim 4 when fabricated into a monolayer tubing has an internal haze less than about 25%.

13. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.08.

14. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.04.

15. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.01.

16. The blend of claim 1 when fabricated into a monolayer tubing has less than about 10 mg of low molecular weight extractible components.

17. The blend of claim 1 when fabricated into a monolayer tubing has a yield strength within the range of from about 500 psi to about 1000 psi.

18. The blend of claim 1 when fabricated into a monolayer tubing has a yield strength of from about 600 psi to about 1000 psi.

19. The blend of claim 1 when fabricated into a monolayer tubing is capable of being used with a medical tubing clamp without significantly damaging the tubing.

20. The blend of claim 1 when fabricated into a monolayer tubing is capable of solvent bonding to a rigid component.

21. The blend of claim 20 wherein the rigid component is fabricated from a cyclic olefin containing polymer or a bridged polycyclic hydrocarbon containing polymer.

22. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.008 g/cc.

23. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.004 g/cc.

24. The blend of claim 1 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.002 g/cc.

25. The blend of claim 1 wherein the process capability of the blend shall be greater than about 1.33 for a dimensional tolerance of +/−

1.7%.

8. The blend of 7 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 100 ft/min.

12. The blend of claim 8 when fabricated into a monolayer tubing has a substantially smooth surface.

9. The blend of 7 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 200 fl/min.

10. The blend of 7 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 300 ft/min.

11. The blend of 7 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 350 ft/min.

26. A polymer blend for fabricating medical products comprising:

a first ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of from about 0% to about 99% by weight of the blend and having a melt flow index from about 0.1 g/10 min to about 5 g/10 min;

a second ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend of from about 0% to about 99% and having a melt flow index from higher than about 5 g/10 min to about 20 g/10 min; and

a third ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index greater than about 20 g/10 min.

27. The blend of claim 26 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.8.

28. The blend of claim 26 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.5.

29. The blend of claim 26 wherein the first, second and third ethylene and α

-olefin copolymers are obtained using a single-site catalyst.

30. The blend of claim 26 wherein the first, second and third ethylene and α

-olefin copolymers are each present in an amount within the range of from about 5% to about 70% by weight of the blend.

31. The blend of claim 26 wherein the first, second and third ethylene and α

-olefin copolymers are each present in substantially equal quantities by weight of the blend.

32. The blend of claim 26 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 30,000 psi.

33. The blend of claim 26 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 20,000 psi.

34. The blend of claim 26 when fabricated into a monolayer tubing has a modulus of elasticity of less than about 10,000 psi.

35. The blend of claim 26 when fabricated into a monolayer tubing has an internal haze less than about 25%.

36. The blend of claim 26 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 100 ft/min.

37. The blend of claim 26 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 200 ft/min.

38. The blend of claim 27 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 300 ft/min.

39. The blend of claim 26 is capable of being fabricated into a monolayer tubing at a throughput rate of greater than about 350 ft/min.

40. The blend of claim 26 when fabricated into a monolayer tubing has a substantially smooth surface.

41. The blend of claim 26 when fabricated into a monolayer tubing has less than about 10 mg of low molecular weight extractible components.

42. The blend of claim 26 when fabricated into a monolayer tubing has a yield strength within the range of from about 500 psi to about 1000 psi.

43. The blend of claim 26 when fabricated into a monolayer tubing has a yield strength of from about 600 psi to about 1000 psi.

44. The blend of claim 26 when fabricated into a monolayer tubing is capable of being used with a medical tubing clamp without significantly damaging the tubing.

45. The blend of claim 26 when fabricated into a monolayer tubing is capable of solvent bonding to a rigid component.

46. The blend of claim 45 wherein the rigid component is fabricated from a cyclic olefin containing polymer or a bridged polycyclic hydrocarbon containing polymer.

47. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.08.

48. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.04.

49. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.01.

50. The blend of claim 26 wherein the process capability of the blend shall be greater than about 1.33 for a dimensional tolerance of +/−

1.7%.

51. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.008 g/cc.

52. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.004 g/cc.

53. The blend of claim 26 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.002 g/cc.

54. A medical tubing comprising:

a sidewall of a polymer blend comprising a first ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of from about 0% to about 99% by weight of the blend and having a melt flow index from about 0.1 g/10 min to about 5 g/10 min, a second ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend of from about 0% to about 99% and having a melt flow index from higher than about 5 g/10 min to about 20 g/10 min, and a third ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index greater than about 20 g/10 min.

55. The tubing of claim 54 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.8.

56. The tubing of claim 54 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.5.

57. The tubing of claim 54 wherein the first, second and third ethylene and α

-olefin copolymers are obtained using a single-site catalyst.

58. The tubing of claim 54 wherein the first, second and third ethylene and α

-olefin copolymers are each present in an amount within the range of from about 5% to about 70% by weight of the blend.

59. The tubing of claim 54 wherein the first, second and third ethylene and α

-olefin copolymers are each present in substantially equal quantities by weight of the blend.

60. The tubing of claim 54 having a modulus of elasticity of less than about 30,000 psi.

61. The tubing of claim 54 having a modulus of elasticity of less than about 20,000 psi.

62. The tubing of claim 54 having a modulus of elasticity of less than about 10,000 psi.

63. The tubing of claim 54 having an internal haze less than about 25%.

64. The tubing of claim 54 is capable of being fabricated at a throughput rate of greater than about 100 ft/min.

65. The tubing of claim 54 is capable of being fabricated at a throughput rate of greater than about 200 ft/min.

66. The tubing of claim 54 is capable of being fabricated at a throughput rate of greater than about 300 ft/min.

67. The tubing of claim 54 is capable of being fabricated at a throughput rate of greater than about 350 ft/min.

68. The tubing of claim 54 has a substantially smooth surface.

69. The tubing of claim 54 having less than about 10 mg of low molecular weight extractible components.

70. The tubing of claim 54 having a yield strength within the range of from about 500 psi to about 1000 psi.

71. The tubing of claim 54 having a yield strength of from about 600 psi to about 1000 psi.

72. The tubing of claim 54 is capable of being used with a medical tubing clamp without significantly damaging the tubing.

73. The tubing of claim 54 is capable of solvent bonding to a rigid component.

74. The tubing of claim 73 wherein the rigid component is fabricated from a cyclic olefin containing polymer or a bridged polycyclic hydrocarbon containing polymer.

75. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.08.

76. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.04.

77. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.01.

78. The tubing of claim 54 wherein the process capability of the tubing shall be greater than about 1.33 for a dimensional tolerance of +/−

1.7%.

79. The tubing of claim 54 is a monolayer tubing.

80. The tubing of claim 54 is a multiple layered tubing wherein the blend defines a layer within the multiple layered tubing.

81. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.008 g/cc.

82. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.004 g/cc.

83. The tubing of claim 54 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.002 g/cc.

84. A medical film comprising:

a polymer blend comprising a first ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of from about 0% to about 99% by weight of the blend and having a melt flow index from about 0.1 g/10 min to about 5 g/10 min, a second ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend of from about 0% to about 99% and having a melt flow index from higher than about 5 g/10 min to about 20 g/10 min, and a third ethylene and α

-olefin copolymer having a molecular weight distribution of less than about 3 and being present in an amount by weight of the blend from about 0% to about 99% and having a melt flow index greater than about 20 g/10 min.

85. The film of claim 84 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.8.

86. The film of claim 84 wherein the first, second and third ethylene and α

-olefin copolymers have a molecular weight distribution of less than about 2.5.

87. The film of claim 84 wherein the first, second and third ethylene and α

-olefin copolymers are obtained using a single-site catalyst.

88. The film of claim 84 wherein the first, second and third ethylene and α

-olefin copolymers are each present in an amount within the range of from about 5% to about 70% by weight of the blend.

89. The film of claim 84 wherein the first, second and third ethylene and α

-olefin copolymers are each present in substantially equal quantities by weight of the blend.

90. The film of claim 84 having a modulus of elasticity of less than about 30,000 psi.

91. The film of claim 84 having an internal haze less than about 25%.

92. The film of claim 84 is capable of being fabricated at a throughput rate of greater than about 300 ft/min.

93. The film of claim 84 is capable of being fabricated at a throughput rate of greater than about 400 ft/min.

94. The film of claim 84 is capable of being fabricated at a throughput rate of greater than about 500 ft/min.

95. The film of claim 84 has a substantially smooth surface.

96. The film of claim 84 having less than about 10 mg of low molecular weight extractible components.

97. The film of claim 84 having a yield strength of from about 500 psi to about 1000 psi.

98. The film of claim 84 is capable of being solvent bonded.

99. The film of claim 84 is a monolayer film.

100. The film of claim 84 is a multiple layered film wherein the blend defines a layer within the multiple layered film.

101. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.08.

102. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.04.

103. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a refractive index with the refractive indicies differing by equal to or less than 0.01.

104. The film of claim 84 wherein the process capability of the film shall be greater than about 1.33 for a dimensional tolerance of +/−

1.7%.

105. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.008 g/cc.

106. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.004 g/cc.

107. The film of claim 84 wherein the first ethylene and α

-olefin copolymer, the second ethylene and α

-olefin copolymer and the third ethylene and α

-olefin copolymer each have a density differing by equal to or less than 0.002 g/cc.