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Polymer conjugates of ara-C and ara-C derivatives

  • US 6,376,470 B1
  • Filed: 09/23/1999
  • Issued: 04/23/2002
  • Est. Priority Date: 09/23/1999
  • Status: Expired due to Fees
First Claim
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1. A compound comprising the formula:

  • embedded imagewherein;

    G is a linear or branched, terminally functionalized polymer residue;

    Y1 is O, S, or NR1;

    M is X or Q;

    wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═

    Y1);

    embedded imageR1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, a C1-6 alkyl, a C3-12 branched alkyl, a C3-8 cycloalkyl, a C1-6 substituted alkyl, a C3-8 substituted cycloalkyl, an aryl, a substituted aryl, an aralkyl, a C1-6 heteroalkyl or a substituted C1-6 heteroalkyl;

    R6 is OR7 or N3, NH2, NO2 or CN, where R7 is selected from the same group which defines R1-5;

    R8-9 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, or R6; and

    a and n are each independently zero or a positive integer.

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