Method for controlled contraction of collagen in fibrous septae in subcutaneous fat layers

• US 6,377,854 B1
• Filed: 12/15/1997
• Issued: 04/23/2002
• Est. Priority Date: 05/05/1995
• Status: Expired due to Term

• Current Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Inventors: Knowlton, Edward W.
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US08/990,494
• Time in Patent Office: 1,590 Days
• Field of Search: 606/2, 606/3-14, 606/31, 606/32-34, 606/37-41, 606/49-51, 607/2, 607/43, 607/50, 607/52, 607/62, 607/96-111, 607/114, 607/115, 607/145, 607/154, 604/20
• US Class Current: 607/101
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/00488 Esophagus
• CPC Class Codes: A61B 2018/0066 without feedback, i.e. open loop control
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment

Abstract

A method and apparatus applies radiant energy through the skin to underlying collagen tissue without substantially modifying melanocytes and other epithelial cells in the epidermis. A membrane is adapted to receive an electrolytic solution and become inflated to substantially conform a contacting exterior surface of the membrane to a skin layer. The membrane includes a cooling lumen for receiving cooling fluid. One or more thermal electrodes positioned in the membrane and transfers thermal energy to the electrolytic solution. The electrolytic solution and cooling fluid creates a reverse thermal gradient from the skin surface to the underlying collagen tissue. A thermal power source is coupled to the thermal electrodes, and a source of electrolytic solution is coupled to the membrane.

Claims

1. A method for modifying soft tissue by contracting collagen in fibrous septae in subcutaneous fat layers comprising:

positioning an apparatus comprising a porous membrane having a skin-contacting surface and a non-skin-contacting surface, and an RF electrode positioned in the membrane, such that the skin-contacting surface of the porous membrane is adjacent an external skin surface of a patient;

introducing electrolytic solution into the porous membrane such that the membrane is inflated to substantially conform the skin-contacting surface of the membrane to the external skin surface of the patient;

transferring energy from the RF electrode to the electrolytic solution to create an energy delivery electrolytic solution; and

treating soft tissue by delivering sufficient amount of energy to contract collagen in fibrous septae in subcutaneous fat layers underlying the skin surface so as to modify a structure of the underlying tissue such that soft tissues in the subcutaneous fat layers are tightened and fat is reduced in lipocytes in the subcutaneous fat layers.

2. The method of claim 1, wherein energy from the energy delivery electrolytic solution to the skin surface creates a controlled cell necrosis.

3. The method of claim 1, wherein modifying a structure of the underlying tissue includes tightening of the skin.

4. The method of claim 1, wherein modifying a structure of the underlying tissue includes tightening the underlying tissue.

5. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled cell necrosis of the skin surface.

6. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled zone of cell necrosis of the skin surface.

7. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled zone of collagen contraction of a dermis and fibrous septae of a subcutaneous tissue.

8. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled zone of skin surface ablation.

9. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled zone of skin tightening.

10. The method of claim 1, wherein treating tissue includes having the energy delivery electrolytic solution receive sufficient energy from the RF electrode to create a controlled zone of subcutaneous tightening.

11. The method of claim 1, wherein treating tissue includes having the electrolytic solution receive sufficient energy from the RF electrode to create a contraction of collagen in the skin.

12. The method of claim 1, wherein treating tissue includes having the electrolytic solution receive sufficient energy from the RF electrode to supply energy through a papillary dermis layer.

13. The method of claim 1, wherein treating tissue includes having the electrolytic solution receive sufficient energy from the RF electrode to supply energy through a reticular dermis layer of the skin.

14. The method of claim 1, wherein treating tissue includes having the electrolytic solution receive sufficient energy from the RF electrode to supply energy through a subcutaneous layer and an underlying soft tissue.

15. The method of claim 1, wherein the RF electrode receives a controlled delivery of energy from an RF power source.

16. The method of claim 1, further comprising:

sensing a temperature of the skin surface during delivery of the energy delivery electrolytic solution to the skin surface.

17. The method of claim 1, further comprising:

sensing a temperature of the skin surface after delivery of the energy delivery electrolytic solution to the skin surface.

18. The method of claim 1, further comprising:

sensing a temperature of a tissue underlying the skin surface during the delivery of the energy delivery electrolytic solution to the skin surface.

19. The method of claim 1, further comprising:

sensing a temperature of a tissue underlying the skin surface after delivery of the energy delivery electrolytic solution to the skin surface.

20. The method of claim 1, further comprising:

sensing an impedance of the skin surface during delivery of the energy delivery electrolytic solution to the skin surface.

21. The method of claim 1, further comprising:

sensing an impedance of the skin surface after delivery of the energy delivery electrolytic solution to the skin surface.

22. The method of claim 1, further comprising:

sensing an impedance of a tissue underlying the skin surface during the delivery of the energy delivery electrolytic solution to the skin surface.

23. The method of claim 1, further comprising:

sensing an impedance of a tissue underlying the skin surface after delivery of the energy delivery electrolytic solution to the skin surface.

24. The method of claim 1, further comprising cooling the skin surface of the patient.

25. The method of claim 24, wherein the cooling the skin surface of the patient is provided by a cooling fluid contained in a cooling fluid lumen positioned in the membrane.