Method and apparatus for determination of a substance coexisting with another substance

• US 6,377,896 B1
• Filed: 01/05/1999
• Issued: 04/23/2002
• Est. Priority Date: 01/06/1998
• Status: Expired due to Term

• Current Assignee: Kyoto Daiichi Kagaku Company Limited
• Original Assignee: Kyoto Daiichi Kagaku Company Limited
• Inventors: Sato, Yoshiharu, Okuda, Hisashi
• Primary Examiner(s): Hoff, Marc S.
• Assistant Examiner(s): Raymond, Edward
• Application Number:
  US09/225,321
• Time in Patent Office: 1,204 Days
• Field of Search: 702/23, 702/22, 356/39, 436/808, 128/92
• US Class Current: 702/23
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: Y10S 436/808 Automated or kit

Abstract

A measuring method for determination of the content of a substance in a specimen on the basis of the value of a physical property measured with the specimen in which the determination is influenced by another substance coexisting with the object substance in the specimen, characterized in that: the value of the physical property measured with the specimen with a known content Ht of the coexisting substance is corrected to a value Vc of the physical property calculated with a standard content value Hts as the content Ht of the coexisting substance on the basis of a correction table showing the relationship between the contents Ht of the coexisting substance and set values V of said physical property for the respective key contents of the object substance. The measuring method permits instantaneous determination with high precision of the content of a substance for which no calibration curve can be prepared because of the effects of a coexisting substance.

Claims

1. A measuring method for the determination of the content of an object substance in a specimen, on the basis of the value of a physical property measured with the specimen, in which the determination is influenced by another substance coexisting in the specimen with the object substance, the measuring method comprising:

measuring the value of the physical property with the specimen in which the content (Ht) of the coexisting substance is known;

preparing a correction table showing the relationship between the content (Ht) of the coexisting substance and the values (V) of the aforesaid physical property set for the respective key contents of the object substance; and

correcting the measured value of the physical property to a corrected value (Vc) of the physical property calculated with a standard content value (Hts) as the content (Ht) of the coexisting substance on the basis of the correction table and the known contents (Htk) of the coexisting substance.

2. The measuring method of claim 1, further comprising deriving the content of the object substance from said corrected value (V) and a main table showing the relationship between the set values (Vs) with the standard content value (Hts) as the content (Ht) of the coexisting substance and the contents of the object substance corresponding to said set values (V).

3. The measuring method of claim 1, wherein the object substance is glucose and the coexisting substance is a blood cell component.

4. A measuring method of claim 3, wherein said physical property is an electric current arising in an oxidizing reaction of glucose.

9. The measuring method of claim 1, wherein the set values (V) vary with known contents (G) of the object substance as a parameter.

5. An apparatus for determining the content of an object substance in a specimen on the basis of the value of a physical property measured with the specimen, in which the measurements are affected by the content of another substance coexisting with the object substance in the specimen, said apparatus comprising:

a correction table showing the relationship between the contents (Ht) of the coexisting substance and the values (V) of the aforesaid physical property set for the respective key contents of the object substance,

a file for storing specific known contents (Htk) of the coexisting substance, and

an arithmetic means for receiving information from the correction table and the file and correcting the value of a physical property measured with a specimen to a corrected value (Vc) calculated with a specific standard content value (Hts) as the content (Ht) of the coexisting substance on the basis of the correction table and the known contents (Htk).

6. The apparatus of claim 5, further comprising a main table showing the relationship between the set values (V) with the standard value (Hts) as the content (Ht) and the contents of the object substance corresponding to said set values (V), wherein said arithmetic means derives the content of the object substance from said corrected value (Vc) on the basis of said main table.

7. The apparatus of claim 5, wherein the object substance is glucose and the coexisting substance is a blood cell component.

8. An apparatus claim 7, wherein said physical property is an electric current arising in an oxidizing reaction of glucose.

10. The apparatus of claim 5, wherein the set values (V) vary with known contents (G) of the object substance as a parameter.