Transferset for vials and other medical containers

• US 6,378,714 B1
• Filed: 10/20/1999
• Issued: 04/30/2002
• Est. Priority Date: 04/20/1998
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Thibault, Jean-Claude, Jansen, Hubert
• Primary Examiner(s): Young, Lee
• Assistant Examiner(s): Eloshway, Niki M.
• Application Number:
  US09/420,979
• Time in Patent Office: 923 Days
• Field of Search: 215/249, 215/251, 215/253, 215/297, 215/DIG.3, 215/247, 215/248, 215/250, 215/252, 215/295, 215/296, 215/308, 215/307, 215/324, 215/325, 215/326, 215/327, 215/341, 215/352, 215/355, 222/81, 222/83, 222/83.5, 141/2, 141/25, 141/26, 141/27, 141/28, 141/329, 141/330, 141/18, 141/21, 604/403, 604/411, 604/412, 604/413, 604/414, 604/415, 604/416, 604/406, 220/265-268, 220/278
• US Class Current: 215/249
• CPC Class Codes: A61J 1/14 Details; Accessories therefor A61J7/00 takes precedence; openers B65D, B67B7/00
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/1425 Snap-fit type
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2086 for fluid filtration
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: B65D 51/002 Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
• CPC Class Codes: Y10S 215/03 Medical

Abstract

An improved transferset assembly for transferring fluids between a first container, such as a medicament vial and a second container, such as a syringe, which includes an integral polymeric transfer assembly having a tubular collar portion, a radial portion overlying the rim of the first container, an outer tubular portion and an inner tubular portion which is integrally joined to the outer tubular portion by a radial intermediate web portion, a piercing member telescopically received in the inner tubular portion having a piercing end to pierce the closure sealing the open end of the first container and a removable closure which seals the open ends of the outer and inner tubular portions of the transfer assembly. The tubular collar portion, which may be separate from the inner and outer tubular portions, is formed of composite polymer including a relatively soft polymer and a relatively rigid polymer, such that the free end of the collar portion may be deformed radially inwardly or crimped into the neck of the first container, yet sufficiently rigid to retain its shape following deformation and resistant to creep to maintain a seal between the transfer assembly and the first container. The proximate end of the inner tubular portion includes a sharp edge which seals against the closure of the first container. The preferred embodiment of the closure is frangibly connected to the free end of the outer tubular portion of the transfer assembly and provides a biological seal.

Claims

1. A polymeric fluid transfer member for transferring fluids from a first container having a radial rim portion surrounding an open end and a second container, comprising:

an integral outer tubular member including a tubular collar portion having an open free end adapted to receive said rim portion of said first container and a proximal end, a generally radial portion integral with said proximate end of said tubular collar portion, and a tubular enclosure portion having a diameter less than said tubular collar portion having a proximate end integrally joined, to said generally radial portion and an open distal end; and

an inner tubular member having a diameter less than said tubular enclosure portion located within and generally coaxially aligned with said tubular enclosure portion in spaced relation having an open proximal end and an open distal end;

wherein said generally radial portion includes an annular barb extending generally perpendicular to said generally radial portion adapted to sealingly engage a polymeric stopper received in said open end of said first container.

2. The polymeric fluid transfer member defined in claim 1, wherein said proximal end of said inner tubular member has a relatively sharp end adapted to sealingly engage a polymeric stopper received within said open end of said first container.

3. The polymeric fluid transfer member defined in claim 1, wherein said inner tubular portion includes threads on an external surface thereof adjacent said distal end.

4. The polymeric fluid transfer member defined in claim 1, in combination with a piercing member telescopically received in said inner tubular portion having a piercing end adjacent said proximal end of said inner tubular portion and a distal end adjacent said open distal end of said inner tubular portion, said piercing member releasably retained in said inner tubular portion and movable with respect thereto to pierce a polymeric stopper received in said open end of said first container.

5. The polymeric fluid transfer member and piercing member as defined in claim 4, wherein said piercing member includes a body portion and said inner tubular portion including an inner surface having an interlocking rib and groove releasably retaining said piercing member in said inner tubular portion.

6. The polymeric fluid transfer member as defined in claim 1 further including a polymeric closure comprising an end portion overlying said open distal end of said tubular enclosure portion and a tubular closure portion integral with said end portion surrounding said open distal end of said tubular enclosure portion, said tubular closure portion comprising first and second tubular portions integrally connected by longitudinal integral frangible portions permitting removal of said closure by breaking said longitudinally extending integral frangible portions.

7. The polymeric fluid transfer member and closure as defined in claim 6, wherein said closure further includes a second tubular closure portion integral with said end portion having a diameter generally equal to an internal diameter of said tubular enclosure portion extending into said open distal end of said tubular enclosure portion.

8. The polymeric fluid transfer member as defined in claim 1, wherein said outer and inner tubular members are integrally formed of a clear polymer which is sufficiently malleable to permit radial deformation of said open free end of said tubular collar portion, yet sufficiently rigid to retain its shape following deformation and sufficiently resistant to creep to maintain a seal between said open free end of said tubular collar portion and said first container following radial deformation and maintain its clarity.

9. A polymeric fluid transfer member for transferring fluids from a first container having a radial rim portion surrounding an open end and a second container, comprising:

an integral outer tubular member including a tubular collar portion having an open free end adapted to receive said rim portion of said first container and a proximal end, a generally radial portion integral with said proximate end of said tubular collar portion, and a tubular enclosure portion having a diameter less than said tubular collar portion having a proximate end integrally joined to said generally radial portion and an open distal end; and

an inner tubular member having a diameter less than said tubular enclosure portion located within and generally coaxially aligned with said tubular enclosure portion in spaced relation having an open proximal end and an open distal end;

wherein said proximal end of said inner tubular member has a relatively sharp end adapted to sealingly engage a polymeric stopper received within said open end of said first container.

10. The polymeric fluid transfer member defined in claim 9, wherein said generally radial portion includes an annular barb extending generally perpendicular to said generally radial portion adapted to sealingly engage a polymeric stopper received in said open end of said first container.

11. A polymeric fluid transfer member for transferring fluids from a first container having a radial rim portion surrounding an open end and a second container, comprising:

an integral outer tubular member including a tubular collar portion having an open free end adapted to receive said rim portion of said first container and a proximal end, a generally radial portion integral with said proximate end of said tubular collar portion, and a tubular enclosure portion having a diameter less than said tubular collar portion having a proximate end integrally joined to said generally radial portion and an open distal end; and

an inner tubular member having a diameter less than said tubular enclosure portion located within and generally coaxially aligned with said tubular enclosure portion in spaced relation having an open proximal end and an open distal end;

wherein said inner tubular member includes threads on an external surface thereof adjacent said distal end for threaded receipt of said second container.

12. A polymeric fluid transfer member for transferring fluids from a first container having a radial rim portion surrounding an open end and a second container, comprising:

an integral outer tubular member including a tubular collar portion having an open free end adapted to receive said rim portion of said first container and a proximal end, a generally radial portion integral with said proximate end of said tubular collar portion, and a tubular enclosure portion having a diameter less than said tubular collar portion having a proximate end integrally joined to said generally radial portion and an open distal end;

an inner tubular member having a diameter less than said tubular enclosure portion located within and generally coaxially aligned with said tubular enclosure portion in spaced relation having an open proximal end and an open distal end; and

a piercing member telescopically received in said inner tubular member having a piercing end adjacent said proximate end of said inner tubular member, a body portion and a distal end adjacent said open distal end of said inner tubular portion, wherein said body portion of said piercing member and an inner surface of said inner tubular member include an interlocking rib and groove releasably retaining said piercing member in said inner tubular member.

13. A polymeric fluid transfer member for transferring fluids from a first container having a radial rim portion surrounding an open end and a second container, comprising:

an integral outer tubular member including a tubular collar portion having an open free end adapted to receive said rim portion of said first container and a proximal end, a generally radial portion integral with said proximate end of said tubular collar portion, and a tubular enclosure portion having a diameter less than said tubular collar portion having a proximate end integrally joined to said generally radial portion and an open distal end;

an inner tubular member having a diameter less than said tubular enclosure portion located within and generally coaxially aligned with said tubular enclosure portion in spaced relation having an open proximal end and an open distal end; and

a polymeric closure comprising an open end overlying said open distal end of said tubular enclosure portion and a tubular closure portion integral with said end portion surrounding said open distal end of said tubular enclosure portion, said tubular closure portion comprising first and second tubular portions integrally connected by longitudinal integral frangible portions permitting removal of said closure by breaking said longitudinally extending integral frangible portions.

14. The polymeric tubular transfer member as defined in claim 13, wherein said closure further includes a second tubular enclosure portion integral with said end portion having a diameter generally equal to an internal diameter of said tubular enclosure portion extending into said open distal end of said tubular enclosure portion.