Opto-acoustic transducer for medical applications

• US 6,379,325 B1
• Filed: 07/09/1999
• Issued: 04/30/2002
• Est. Priority Date: 04/24/1996
• Status: Expired due to Fees

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Da Silva, Luiz, Maitland, Duncan, Glinsky, Michael, Lee, Abraham, London, Richard, Krulevich, Peter, Benett, William, Matthews, Dennis, Celliers, Peter
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/350,494
• Time in Patent Office: 1,026 Days
• Field of Search: 604/20, 604/21, 604/22, 606/15, 606/7, 606/2.5, 606/10, 606/2, 606/3, 606/13-16, 606/127, 606/128
• US Class Current: 604/22
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 18/26 for producing a shock wave, e.g. laser lithotripsy
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2090/378 using ultrasound

Abstract

This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

Claims

1. A method for removing a vascular occlusin, comprising:

inserting a catheter into a blood vessel, wherein said catheter comprises;

a fiber optic having a proximal end and a distal end; and

an opto-acoustic transducer fixedly and operatively connected to said distal end of said fiber optic, wherein said opto-acoustic transducer comprises a working fluid, wherein said opto-acoustic transducer vibrates when stimulated by light propagated through said fiber optic; and

said method further comprising coupling a high repetition rate laser beam into said fiber, wherein said beam is absorbed by said working fluid, wherein said transducer generates acoustic waves to remove a vascular occlusion within said blood vessel.

2. The method of claim 1, wherein said high repetition rate laser beam has a pulse frequency within the range of 10 Hz to 100 kHz.

3. The method of claim 1, wherein said high repetition rate laser beam has a wavelength within the range of 200 nm to 5000 nm.

4. The method of claim 1, wherein said high repetition rate laser beam has a pulse energy density within the range of 0.01 J/cm² to 4 J/cm².

5. The method of claim 1, wherein said high repetition rate laser beam has a pulse duration of less than 200 ns.

6. The method of claim 1, wherein said high repetition rate laser beam has a pulse duration that is sinusoidal.

7. The method of claim 1, wherein said high repetition rate laser beam has a pulse duration that is less than 1 μ

s.

8. The method of claim 1, wherein said high repetition rate laser beam has (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy density within the range of 0.01 J/cm² to 4 J/cm² and (iv) a pulse duration of less than 200 ns.

9. The method of claim 1, wherein said high repetition rate laser beam has (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy within the range of 0.01 J/cm² to 4 J/cm² and (iv) a sinusoidal pulse waveform.

10. The method of claim 1, wherein said high repetition rate laser beam has (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy density within the range of 0.01 J/cm² to 4 J/cm² and (iv) a pulse duration that is less than 1 μ

s.