Metal stent containing radioactivatable isotope and method of making same

• US 6,379,380 B1
• Filed: 08/29/2000
• Issued: 04/30/2002
• Est. Priority Date: 03/11/1998
• Status: Expired due to Fees

• Current Assignee: Stanley Satz
• Original Assignee: Stanley Satz
• Inventors: Satz, Stanley
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US09/650,151
• Time in Patent Office: 609 Days
• Field of Search: 600/3, 623/1.15, 623/1.34
• US Class Current: 623/1.15
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1282 Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

A metal stent for vascular implantation comprising a generally tubular structure whose extend surface is adapted to engage the interior vascular surface when implanted, said metal of said stent containing a substantially uniform dispersion of from about 0.05 to about 10.00 percent by weight of one or more naturally occurring or enriched stable isotopes having a half-life of less than two months and that are principally beta particle emitters, so that when activated, said stent emits low to moderate dosages of radiation uniformly to reduce cell proliferation.

Claims

1. A medical procedure, which comprises:

(a) selecting a generally tubularly-shaped stent of a biocompatible metal of a substantially uniform dispersion of from about 0.05 to about 10.00 percent by weight of an enriched radioactivatable isotope having a half-life of less than two months and principally a beta particle emitter;

(b) radioactivating said stent to a dosage of radiation; and

(c) implanting said radioactivated stent within inner lumens of a cardiovascular passageway to engage said inner lumens of said cardiovascular passageway thereby to provide support against collapse of said cardiovascular passageway and to provide radiation therapy.

2. The medical procedure as defined in claim 1 wherein said biocompatible metal is tantalum.

3. The medical procedure as defined in claim 1 wherein said biocompatible metal is an alloy of nickel and chromium.

4. The medical procedure as defined in claim 1 wherein said biocompatible metal is an alloy of nickel and titanium.

5. The medical procedure as defined in claim 1 wherein said stent is activated to a level of from 20 microcuries to 50 millicuries.

6. The medical procedure as defined in claim 1 wherein said enriched radioactivatable isotope is selected from the group consisting of astatine-211, erbium-169, gadolinium-159, holmium-166, lutetium-177, palladium-203, samarium-153, scandium-47, strontium-89, vanadium-48, and ytterbium-175 and mixture thereof.

7. The medical procedure as defined in claim 1 wherein said enriched radioactivatable isotope is selected from the group consisting of antimony-120, antimony-127, barium-128, barium-131, barium-140, bromine-80, cadmium-115, cerium-134, cerium-141, cerium-143, cobalt-55, copper-64, copper-67, dysprosium-166, erbium-172, gallium-166, gallium-68, germanium-71, gold-198, gold-199, iodine-124, iodine-125, iodine-131, iridium-194, lanthanum-140, lutetium-172, neodymium-140, nickel-66, niobium-95, osmium-191, palladium-100, phosphorus-32, phosphorus-33, platinum-188, platinum-191, platinum-193, platinum-195, platinum-197, praseodymium-143, rhenium-196, rhenium-188, rhodium-99, rhodium-101, rhodium-103, rhodium-103, rubidium-82, ruthenium-103, scandium-48, silver-111, strontium-82, tantalum-177, tantalum-183, tellurium-132, tellurium-118, terbium-153, terbium-156, thallium-201, thallium-204, thulium-167, thulium-172, tin-117, tin-121, titanium-45, tungsten-178, ytterbium-166, ytterbium-169, yttrium-87, yttrium-90, yttrium-91, zinc-72, and zirconium-89 and mixture thereof.