Porous prosthesis and a method of depositing substances into the pores
First Claim
Patent Images
1. An implantable prosthesis, comprising:
- a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed on at least a region of said outer surface, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled location and a preselected and controlled depth; and
a substance deposited into said depots.
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Abstract
An implantable prosthesis, for example a stent, is provided that is capable of being loaded with substances. In one example, the prosthesis is a cylindrical-shaped body having depots or pores formed thereon. The depots can be formed at preselected locations on the body of the prosthesis and can have a preselected depth, size, and shape. The depots can have various shapes including a cylindrical or a conical shape. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.
791 Citations
21 Claims
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1. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed on at least a region of said outer surface, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled location and a preselected and controlled depth; and
a substance deposited into said depots. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed therein, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled distribution, a preselected and controlled depth, and a preselected depot shape, wherein said preselected depot shape is generally conical.
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8. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed therein, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled distribution, a preselected and controlled depth, and a generally conical shape, wherein said conical shaped depot has an open end and a closed end, said open end contacts said inner lumen surface of said passageway, and said open end has a diameter smaller than a diameter of said closed end. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed on at least a region of said outer surface, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled location and a preselected and controlled depth; and
a substance deposited into said depots, wherein said substance is a polymeric material containing a therapeutic substance.
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17. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed on at least a region of said outer surface, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled location and a preselected and controlled depth; and
a substance deposited into said depots, wherein said substance is a polymeric material containing a therapeutic substance, said therapeutic substance is selected from a group of antineoplastic, antiplatelet, anticoagulant, fibrinolytic, antimitotic, thrombin inhibitor, antiinflammatory, and antiproliferative substances.
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18. An implantable prosthesis, comprising:
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a body structure having a generally cylindrical shape, an outer surface capable of contacting an inner lumen surface of a passageway, and a hollow bore which extends longitudinally through said body structure to define an inner surface, said body structure having a thickness;
said body structure having a plurality of depots formed on at least a region of said outer surface, said depots having a depth less than said thickness of said body structure, and said depots having a preselected and controlled location and a preselected and controlled depth; and
a substance in said depots, the substance being loaded in the depots by applying a first fluid including the substance to said prosthesis, wherein during said act of applying, said first fluid penetrates into said depots, removing said first fluid from said prosthesis, applying a second fluid to said prosthesis wherein during said act of applying said second fluid, said second fluid does not significantly penetrate into said depots, and removing said second fluid from said prosthesis such that said substance is deposited into said depots, wherein said substance is selected from a group of therapeutic substances, polymeric material, or a combination thereof.
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19. A stent comprising:
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a radially expandable body; and
depots located on a selected area of the surface of said body wherein the depots are conically shaped cavities having an open end and a closed end, said open end having a dimension that is smaller than a dimension of said closed end. - View Dependent Claims (20, 21)
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Specification