Enhancing immune response in animals

• US 6,379,676 B2
• Filed: 03/10/1999
• Issued: 04/30/2002
• Est. Priority Date: 03/10/1999
• Status: Expired due to Term

• Current Assignee: Anitox Corporation
• Original Assignee: Anitox Corporation
• Inventors: Richardson, Kurt E.
• Primary Examiner(s): Graser, Jennifer E.
• Application Number:
  US09/265,821
• Publication Number:
  US 20010009668A1
• Time in Patent Office: 1,147 Days
• Field of Search: 424/130.1, 424/150.1, 424/184.1, 424/234.1, 424/240.1, 424/241.1, 424/256.1, 424/258.1, 424/264.1, 424/232.1, 426/2, 426/335, 426/532, 426/302
• US Class Current: 424/234.1
• CPC Class Codes: A61K 2039/545 characterised by the dose, timing or administration schedule
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61P 37/04 Immunostimulants

Abstract

A method for improving the immune response of an animal to a vaccine, comprising: feeding an animal a diet of contamination-resistant feed, and treating said animal with an anti-viral or anti-bacterial vaccine.

Claims

1. A method for increasing the level of antibodies in eggs, colostrum or milk produced by a group of breeding animals in response to a vaccination, comprising:

enhancing the uniformity of response within said group to a primary vaccination, by maintaining the group of breeding animals on a diet of contamination-resistant, formaldehyde-treated feed having a coefficient of variation of 7% or less, then subjecting said animals to a secondary immunization with the same vaccine.

2. The method of claim 1, wherein said vaccine is selected from the group consisting of a vaccine against Marek'"'"'s disease, Newcastle disease-infectious bronchitis, laryngotracheitis, avian encephalomyletis, fowl pox, pseudorabies, influenza, transmissible gastroenteritis, porcine reproductive and respiratory syndrome, foot and mouth disease, and parvovirus.

3. The method of claim 1, wherein said vaccine is a bacterin selected from the group consisting of Salmonella enteritidis, Salmonella cholerasuis, Streptococcus suis, Escherichia coli, Mycoplasma galliseptum, Mycoplasma hyopneumonia, Erysipelas, Bordetella, Leptosprias species, Actinobacillus pleuropneumonia and Haemophilis species.

4. The method of claim 1, wherein said diet consists of formaldehyde-treated feed having a coefficient of variation of 5% or less.

5. The method of claim 1, wherein the animals are selected from the group consisting of chicken, turkey and duck.

6. The method of claim 1, wherein the breeding animals are selected from the group consisting of cow, sheep, pig or horse.

7. A method for improving the immune response of a group of animals to a vaccine, comprising:

enhancing the uniformity of response within a group of animals to a primary vaccination by maintaining said group on a diet of contamination-resistant, formaldehyde-treated feed having a coefficient variation of 7% or less, then subjecting said animals to a secondary immunization with the same vaccine.

8. The method of claim 7, wherein said vaccine is selected from the group consisting of a vaccine against Marek'"'"'s disease, Newcastle disease-infectious bronchitis, laryngotracheitis, avian encephalomyletis, fowl pox, pseudorabies, influenza, transmissible gastroenteritis, porcine reproductive and respiratory syndrome, foot and mouth disease, and parvovirus.

9. The method of claim 7, wherein said vaccine is a bacterin selected from the group consisting of Salmonella enteritidis, Salmonella cholerasuis, Streptococcus suis, Escherichia coli, Mycoplasma galliseptum, Mycoplasma hyopneumonia, Erysipelas, Bordetella, Leptosprias species, Actinobacillus pleuropneumonia and Haemophilis species.

10. The method of claim 7, wherein said diet consists of formaldehyde-treated feed having a coefficient of variation of 5% or less.

11. The method of claim 7, wherein the animals are selected from the group consisting of chicken, turkey and duck.

12. The method of claim 7, wherein the animals are selected from the group consisting of cow, sheep, pig and horse.