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Nucleotide compound, nucleotide block oligonucleotide, and method for producing them

  • US 6,380,378 B1
  • Filed: 12/23/1999
  • Issued: 04/30/2002
  • Est. Priority Date: 12/24/1998
  • Status: Expired due to Fees
First Claim
Patent Images

1. A nucleotide compound represented by the following formula (I):

  • embedded imagewherein R1 represents a protective group or an organic group represented by the formula —

    C(═

    O)—

    A′



    (OCH2CH2)kOCH3 in which k represents an integer of 3 or more, and A′

    is a divalent organic group;

    R2, R2′

    , R3 and R3′

    each represents a hydrogen atom or an alkyl, cycloalkyl, aryl or aralkyl group which may contain a hetero-atom and R2, R2′

    , R3 and R3′

    may be the same or different;

    B1 and B2 each represents a base, optionally, protected by a protective group common in nucleotide chemistry or B′

    which represents —

    B1′



    C(═

    O)—

    A—

    (OCH2CH2)kOCH3 in which B1′

    represents one of the groups represented by the embedded imagek represents an integer of 3 or more, A is a divalent group and represents an arylene group or an alkylene group having a straight or branched chain which may contain a heteroatom;

    X represents an oxygen atom or a sulfur atom;

    Y represents an azolyl group, a monoalkylamino group represented by HNR5 in which R5 is an alkyl group or a cycloalkyl group, a dialkylamino group or a saturated nitrogenous heterocyclic ring;

    A1 and A2 each represents a hydrogen atom, a hydroxyl group, an alkoxy group or a trialkylsilyloxy group; and

    n represents 0 or an integer of 1 to 100;

    excluding the case wherein at least one of the combinations of R2 and R3 and of R2′

    and R3′

    being a hydrogen atom and hydrogen atom, a hydrogen atom and a methyl group, a hydrogen atom and an ethyl group, a methyl group and a methyl group, a methyl group and an ethyl group or an ethyl group and an ethyl group.

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