Needleless syringe with prefilled cartridge

• US 6,383,168 B1
• Filed: 03/30/2000
• Issued: 05/07/2002
• Est. Priority Date: 12/08/1998
• Status: Expired due to Term

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Medical Technologies Inc. (Inovio Pharmaceuticals, Inc.)
• Inventors: Landau, Sergio, Bonicatto, James M.
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): Sirmons, Kevin C.
• Application Number:
  US09/539,731
• Time in Patent Office: 768 Days
• Field of Search: 604/236, 604/68, 604/238, 604/249, 604/118, 604/131, 604/121, 604/140, 604/141, 604/146, 604/156, 604/218, 604/231, 604/232, 604/264
• US Class Current: 604/268
• CPC Class Codes: A61M 2005/2462 by displacing occluding plugs
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3106 Plugs for syringes without needle
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

In accordance with an embodiment of the invention, a needleless injection apparatus includes a cartridge having a plunger disposed at a rearward end. The cartridge includes an inner portion with a throat at a forward portion and a displaceable outlet valve initially disposed within the cartridge throat. The cartridge further includes a generally outwardly facing surface and a system for selectively providing driving force to drive the plunger in a forward direction. The apparatus also includes a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and having a forward portion terminating in and defining a valve abutment surface with a plurality of channels and an injection orifice. The forward portion of the nozzle being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, and so that the inner portion of the cartridge has fluid access to the orifice via the channels. The nozzle further includes a generally inwardly facing surface that abuts the cartridge surface, and a seal disposed between the outwardly facing surface of the cartridge and the inwardly facing surface of the nozzle for at least reducing leakage of injectate therebetween.

Claims

1. A cartridge and nozzle assembly for use in a needleless injection system, comprising:

a cartridge having a plunger disposed at a rearward end thereof, and including an inner portion with a throat at a forward portion thereof, the cartridge further including a generally laterally extending interface surface;

a displaceable outlet valve initially disposed within the throat, the outlet valve having a channel-less valve body;

a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and including a forward portion defining a valve-receiving portion with a plurality of channels and an injection orifice defined therein, the forward portion being configured to receive the valve when the valve is displaced to a forwardly disposed position, so that when the outlet valve is displaced from the throat into the valve-receiving portion of the nozzle, the inner portion of the cartridge has fluid access to the orifice via the channels, the nozzle further including a generally laterally extending interface surface which abuts the cartridge interface surface; and

a seal disposed between the cartridge and the nozzle rearward of the interface surfaces for at least reducing leakage of injectate therebetween.

2. The assembly of claim 1 wherein the cartridge throat is tapered and the seal is mounted in a gap defined between the cartridge and the nozzle, adjacent to the cartridge throat.

3. The assembly of claim 1 wherein the valve-receiving portion of the nozzle is in the form of a recessed portion with a valve abutment surface having the channels defined therein.

4. The assembly of claim 3 wherein the channels include generally axially-extending portions in the recessed portion of the nozzle.

5. The assembly of claim 1 wherein the outlet valve has smooth and regular surfaces.

6. The assembly of claim 5 wherein the outlet valve is rounded.

7. The assembly of claim 6 wherein the outlet valve is generally spherical.

8. The assembly of claim 7 wherein the outlet valve is resilient.

9. The assembly of claim 8 wherein the cartridge is formed of glass.

14. The assembly of claim 1 wherein the outlet valve is resilient.

10. A needleless injection apparatus, comprising:

a cartridge having a plunger disposed at a rearward end thereof, and including an inner portion with a throat at a forward portion thereof,

a displaceable outlet valve initially disposed within the cartridge throat, the cartridge further including a generally outwardly facing surface;

a system for selectively providing driving force to drive the plunger in a forward direction;

a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and including a forward portion terminating in and defining a valve abutment surface having a plurality of channels and an injection orifice defined therein, the forward portion being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, and so that the inner portion of the cartridge has fluid access to the orifice via the channels, the nozzle further including a generally inwardly facing surface which abuts the cartridge surface; and

a seal disposed between the outwardly facing surface of the cartridge and the inwardly facing surface of the nozzle for at least reducing leakage of injectate therebetween.

11. The assembly of claim 10 wherein the valve abutment surface is cup-shaped.

12. The assembly of claim 11 wherein the outlet valve is rounded in at least the front end.

13. The assembly of claim 12 wherein the outlet valve is generally spherical.

15. A method for preparing a needleless injection system, comprising:

selecting a glass cartridge with a plunger positionable at a rearward end and an inner portion with a throat at a forward portion, and an outlet valve positionable within the throat, the cartridge further including a generally laterally extending interface surface;

positioning a seal on the cartridge rearward of the laterally extending interface surface;

positioning one of the plunger or the outlet valve within the cartridge;

filling the cartridge with injectate prior to positioning the other of the plunger or the outlet valve in the cartridge;

positioning the other of the plunger or the outlet valve within the cartridge;

selecting a nozzle which includes a rearward, cartridge-receiving portion and a forward portion defining a valve-receiving portion with a plurality of channels and an injection orifice defined therein, the forward portion being configured to receive the valve when the valve is displaced to a forwardly disposed position, the nozzle further including a generally laterally extending interface surface; and

installing the cartridge into the nozzle to form a cartridge/seal assembly such that the interface surfaces are in abutment and the seal is disposed rearwardly of such abutment.

16. The method of claim 15, further comprising positioning an anti-contamination cap on the front of the nozzle.

17. The method of claim 15, further comprising mounting the cartridge/nozzle assembly to the front end of an injector by exerting rearward pressure on the assembly such that an injector ram exerts forward pressure on the plunger, causing the outlet valve to be displaced from the throat and into the valve-receiving portion and resulting in the injectate displacing air in the forward portion of the nozzle.

18. The method of claim 17, further comprising effecting injection by activating the injector, causing the injector ram to push forwardly on the plunger, thereby causing injectate to be driven out of the nozzle orifice.