Retrograde venous perfusion with isolation of cerebral circulation

• US 6,383,172 B1
• Filed: 04/02/1999
• Issued: 05/07/2002
• Est. Priority Date: 04/02/1999
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Coaxis Incorporated (Trimble Inc.)
• Inventors: Barbut, Denise R.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/285,939
• Time in Patent Office: 1,131 Days
• Field of Search: 604/4-6, 604/264, 604/524, 604/525, 604/93, 604/4.01, 604/6.11, 604/6.13, 604/6.14, 604/6.16, 604/24, 604/27-28, 604/43, 604/500, 604/505, 604/507-9, 604/113, 604/96.02, 604/94.01, 604/101.04, 604/102-1-1, 604/523-33, 604/538, 604/539, 604/DIG.912, 604/DIG.915, 604/104, 604/101.03, 604/93.01, 604/95.03, 604/96.01, 604/98.01, 606/20-22, 606/191-94, 600/301, 600/363, 600/433-35, 600/481, 600/483, 600/485-86, 600/488, 422/44, 128/898, 128/905, 128/DIG.3, 128/13
• US Class Current: 604/509
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum

Abstract

A medical device for providing retrograde venous perfusion to the cerebral vasculature for treatment of global or focal cerebral ischemia is disclosed. The device includes a catheter having an infusion port at its distal end, venous drainage port(s), and an expandable occluder disposed between the infusion port and drainage port(s). The catheter is adapted for insertion in the superior vena cava or the internal jugular vein. The catheter is attached proximally to a pump and an oxygenator with or without a cooling system. Alternatively, the device comprises two catheters, each having a lumen communicating with a distal infusion port and an occluder mounted proximal to the port. The catheters are adapted for insertion in the internal jugular veins distal to jugular venous valves. Methods of using the devices to provide retrograde venous perfusion and isolated cerebral hypothermia are disclosed.

Claims

1. A method for retrograde venous perfusion, comprising the steps of:

providing a catheter having a proximal end, a distal end, a first lumen extending from the proximal end to an infusion port located at the distal end, an expandable occluder located proximal the infusion port, and a second lumen extending from the proximal end to a return port located proximal the expandable occluder;

inserting the catheter into the vena cava;

positioning the occluder in the superior vena cava;

expanding the occluder;

withdrawing venous blood from the vena cava through the return port and the second lumen; and

infusing oxygenated medium into the superior vena cava through the first lumen and infusion port, wherein oxygenated medium is returned to the cerebral tissues by retrograde venous perfusion.

2. The method of claim 1, wherein the expandable occluder is a balloon occluder.

3. The method of claim 2, wherein the balloon occluder is an elastomeric balloon.

4. The method of claim 1, wherein the catheter further comprises a manometer located distal the occluder for measuring distal blood pressure.

5. The method of claim 1, wherein the catheter is inserted into the vena cava through the femoral vein.

6. The method of claim 1, wherein the oxygenated medium is blood.

7. The method of claim 1, wherein the oxygenated medium is hypothermic.

8. The method of claim 1, wherein the proximal end of the second lumen is connected to a bypass-oxygenator machine.

9. The method of claim 8, wherein oxygenated medium from the bypass-oxygenator machine is returned to the first lumen of the catheter.

10. The method of claim 1, wherein the second lumen of the catheter communicates with a plurality of drainage ports.

11. A method for retrograde venous perfusion, comprising the steps of:

providing a catheter having a proximal end, a distal end, a first lumen extending from the proximal end to an infusion port located at the distal end, an expandable occluder located proximal the infusion port, and a second lumen extending from the proximal end to a return port located proximal the expandable occluder;

inserting the catheter into the vena cava;

positioning the occluder in the superior vena cava;

expanding the occluder;

withdrawing venous blood from the vena cava through the return port and the second lumen;

passing the venous blood to a bypass-oxygenator machine;

infusing oxygenated medium into the superior vena cava through the first lumen and infusion port, wherein the oxygenated medium is returned to the cerebral tissues by retrograde venous perfusion;

connecting a proximal end of a third lumen to the bypass-oxygenator machine;

inserting a distal end of the third lumen into a femoral artery; and

infusing a second portion of oxygenated medium from the bypass-oxygenator machine into the femoral artery.

12. The method of claim 11, wherein the expandable occluder is a balloon occluder.

13. The method of claim 12, wherein the balloon occluder is an elastomeric balloon.

14. The method of claim 11, wherein the catheter further comprises a manometer located distal the occluder for measuring distal blood pressure.

15. The method of claim 11, wherein the catheter is inserted into the vena cava through the femoral vein.

16. The method of claim 11, wherein the oxygenated medium is blood.

17. The method of claim 11, wherein the oxygenated medium is hypothermic.

18. The method of claim 11, wherein the oxygenated medium from the bypass-oxygenator machine is returned to the first lumen of the catheter.

19. The method of claim 11, wherein the second lumen of the catheter communicates with a plurality of drainage ports.