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Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

  • US 6,383,471 B1
  • Filed: 04/06/1999
  • Issued: 05/07/2002
  • Est. Priority Date: 04/06/1999
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition comprising:

  • (a) a hydrophobic theraputic agent having at least one ionizable functional group and an intrinsic water solubility of less than about 1% by weight; and

    (b) a carrier comprising;

    (i) an ionizing agent capable of ionizing the at least one ionizable functional group, wherein the ionizing agent is present in an amount of at least about 0.1 mole equivalents per mole of the at least one functional group;

    (ii) a surfactant selected from the group consisting of non-ionic hydrophilic surfactants having an HLB value greater than or equal to about 10, ionic hydrophilic surfactants, hydrophobic surfactants having an HLB value less than 10, and mixtures thereof; and

    (iii) a triglyceride.

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