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Methods of obtaining compounds that interact with a human serotonin (5-HT2) receptor

  • US 6,383,762 B1
  • Filed: 09/02/1998
  • Issued: 05/07/2002
  • Est. Priority Date: 10/31/1989
  • Status: Expired due to Fees
First Claim
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1. A method of obtaining a composition comprising a compound that specifically binds to a human 5-HT2 receptor, said method comprising determining whether a chemical compound specifically binds to a human 5-HT2 receptor expressed on the surface of a mammalian cell transfected with a vector adapted for expressing the receptor in the cell, and if the compound specifically binds to the receptor, admixing the compound with a carrier, wherein the human 5-HT2 receptor comprises an amino acid sequence (a) identical to the amino acid sequence of the human 5-HT2 receptor shown in FIG. 2 (SEQ ID NO:

  • 2) or (b) identical to the amino acid sequence of the human 5-HT2 receptor encoded by plasmid pM05-6B (ATCC Accession No.

         40696).

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