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Stabilized aqueous peptide solutions

  • US 6,384,016 B1
  • Filed: 03/08/1999
  • Issued: 05/07/2002
  • Est. Priority Date: 03/13/1998
  • Status: Expired due to Fees
First Claim
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1. A stabilized aqueous composition comprising at least one peptide selected from the group consisting of glucagon, glucagon-like peptide-1 (GLP-1), and analogues and derivatives thereof, together with a stabilizing and solubilizing amount of at least one detergent, wherein the detergent has at least 2 positive charges, at least 2 negative charges, or a combination of at least one positive charge and at least one negative charge, the peptide being present in a concentration of about 0.1-10 mg/ml, with the proviso that the detergent is not dodecyl phosphocholine, and wherein a stabilizing and solubilizing detergent is selected from the group consisting of (i) a 1-acyl-sn-glycero-3-phosphate ester of ethanolamine, choline, serine or threonine;

  • and (ii) lauroyl lysophosphotidylcholine or myristoyl lysophosphatidylcholine.

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