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Process for the preparation of mineralized collagen fibrils and their uses as bone substitute material

  • US 6,384,196 B1
  • Filed: 03/24/1999
  • Issued: 05/07/2002
  • Est. Priority Date: 03/24/1998
  • Status: Expired due to Term
First Claim
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1. A process for the preparation of mineralized collagen fibrils, comprising mixing an acidic solution of uncrosslinked collagen molecules, wherein the solution comprises a calcium-based mineral, with a neutral buffer solution, wherein mineralization of the fibrils begins at an acid pH, thereby forming the fibrils and mineralizing them in one step,wherein the collagen recombinant collagen.

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