Method and apparatus for high-resolution detection and characterization of medical pathologies
First Claim
1. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
- (a) a radiation source adapted to emit radiation within a predetermined frequency range onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;
(b) a plurality of radiation detectors being disposed to surround at least a portion of such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;
(c) means for controlling said radiation source and said plurality of radiation detectors to emit and receive radiation; and
(d) a device coupled to said plurality of radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such medical pathology within said volume.
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Abstract
The present invention relates to a method and apparatus for the construction and/or use of multidimensional fields that can be used for high-resolution detection and characterization of features within objects. The multidimensional field is constructed from data that is collected by an array of radiation detectors that substantially surround the object under study. The detected radiation is produced by an array of radiation sources and is subsequently scattered, reflected, transmitted, or diffracted by the object under study and any features within the object under study. In particular embodiments of the invention, the radiation that is used is ultrasonic radiation and the object under study is human or animal tissue or an organ. In this case, the invention permits the detection and identification of cancer by an intelligently trained evaluation system.
243 Citations
79 Claims
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1. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
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(a) a radiation source adapted to emit radiation within a predetermined frequency range onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;
(b) a plurality of radiation detectors being disposed to surround at least a portion of such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;
(c) means for controlling said radiation source and said plurality of radiation detectors to emit and receive radiation; and
(d) a device coupled to said plurality of radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such medical pathology within said volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
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(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such object;
(b) a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such object to receive ultrasound radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the ultrasound radiation received;
(c) means for controlling said plurality of ultrasound radiation sources and said plurality of radiation detectors to emit and receive ultrasound radiation; and
(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such medical pathology within said volume.
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40. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
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(a) a plurality of devices adapted both to emit radiation within a predetermined frequency range onto a volume within such object and to receive radiation scattered by said volume, said plurality of devices being disposed to surround at least a portion of such object so as to be capable of insonifying such object and said plurality of devices being capable of providing data corresponding to the radiation received;
(b) means for controlling said plurality of devices; and
(c) a computational device coupled to said plurality of devices and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of devices, and to detect and characterize such medical pathology within said volume.
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41. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
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(a) a plurality of devices adapted both to emit ultrasound radiation within a predetermined frequency range onto a volume within such object and to receive ultrasound radiation scattered by said volume, said plurality of devices being disposed to surround at least a portion of such object so as to be capable of insonifying such object and said plurality of devices being capable of providing data corresponding to the ultrasound radiation received;
(b) means for controlling said plurality of devices; and
(c) a computational device coupled to said plurality of devices and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of devices, and to detect and characterize such medical pathology within said volume.
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42. Apparatus for detection and characterization of a medical pathology within a human breast, comprising:
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(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such object;
(b) a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such object to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;
(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and
(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such medical pathology within said volume.
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43. Apparatus for detection and characterization of a medical pathology within an object under study, comprising:
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(a) a radiation source adapted to emit radiation within a predetermined frequency range onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;
(b) at least 5,000 radiation detectors being disposed to surround at least a portion of such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;
(c) means for controlling said radiation source and said at least 5,000 radiation detectors to emit and receive radiation; and
(d) a device coupled to said at least 5,000 radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said at least 5,000 radiation detectors, and to detect and characterize such medical pathology within said volume.
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44. Apparatus for detection and characterization of cancer within biological tissue, comprising:
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(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range onto a volume within such biological tissue, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such biological tissue;
(b) a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;
(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and
(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.
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45. Apparatus for detection and characterization of cancer within biological tissue, comprising:
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(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range onto a volume within such biological tissue, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such biological tissue;
(b) a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue to receive ultrasound radiation scattered by said volume said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;
(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and
(d) an expert system coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume, using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.
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46. Apparatus for detection and characterization of cancer within biological tissue, comprising:
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(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range onto a volume within such biological tissue, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such biological tissue;
(b) a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;
(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and
(d) a neural net coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.
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47. Method for detection and characterization of a medical pathology within an object under study, comprising the steps of:
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(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range;
(b) receiving, using a plurality of radiation detectors being disposed to surround at least a portion of such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of detectors; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
(a) estimating a three-dimensional shape of said object under study based on said data;
(b) constructing an estimated multidimensional field rendering of said object under study based on said three-dimensional shape and based on physiological data derived from at least one physiological characteristic;
(c) computing estimated radiation data that would be produced by said estimated multidimensional field rendering of said object under study;
(d) testing the difference between said data and said estimated radiation data against a predetermined level of noise;
(e) adjusting said physiological data to calculate a new estimated multidimensional field rendering of said object under study; and
(f) iterating steps (c) through (e) until the difference between said data and said estimated radiation data is below the predetermined level of noise.
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51. The method according to claim 47, wherein said radiation is ultrasound radiation.
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52. The method according to claim 47, wherein said object under study is a plurality of biological tissues.
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53. The method according to claim 52, wherein said plurality of biological tissues is a human breast.
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54. The method according to claim 52, wherein said plurality of biological tissues is a human prostate.
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55. The method according to claim 52, wherein said plurality of biological tissues is a human lung.
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56. The method according to claim 52, wherein said plurality of biological tissues is a section of a human alimentary canal.
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57. The method according to claim 52, wherein said plurality of biological tissues is a human liver.
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58. The method according to claim 52, wherein said multidimensional field rendering comprises sound speeds and sound absorptions for a plurality of volume elements occupied by said plurality of biological tissues.
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59. The method according to claim 52, further comprising the step of classifying said plurality of biological tissues based on said multidimensional field rendering.
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60. The method according to claim 52, further comprising the step of identifying closed volumes in said plurality of biological tissues based on said multidimensional field rendering.
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61. The method according to claim 60, further comprising the step of determining the quasifractal dimension of said closed volumes based on said multidimensional field rendering.
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62. The method according to claim 52, further comprising the step of identifying angiogenesis in said plurality of biological tissues based on said multidimensional field rendering.
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63. The method according to claim 52, further comprising the step of applying a vibration source in contact with said plurality of biological tissues based on said multidimensional field rendering.
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64. The method according to claim 52, further comprising the step of identifying microcalcifications in said plurality of biological tissues based on said multidimensional field rendering.
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65. The method according to claim 52, further comprising the step of identifying the electrical impedance of said plurality of biological tissues based on said multidimensional field rendering.
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66. The method according to claim 47, further comprising the step of storing said multidimensional field rendering.
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67. The method according to claim 66, wherein said step of storing said multidimensional field rendering is accomplished by lossless compression.
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68. The method according to claim 47, further comprising the step of comparing said multidimensional field rendering with an earlier stored multidimensional field rendering of said object under study.
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69. The method according to claim 68, wherein said step of comparing said multidimensional field rendering with an earlier stored multidimensional field rendering of said object under study comprises the substep of morphing said earlier stored multidimensional field rendering into said multidimensional field rendering.
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70. Method for detection and characterization of a medical pathology within an object under study, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such object, upon a volume within the object under study with ultrasound radiation within a predetermined frequency range;
(b) receiving, using a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such object, ultrasound radiation scattered by said volume within the object and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume.
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71. Method for detection and characterization of a medical pathology within an object under study, comprising the steps of:
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(a) irradiating, using a plurality of devices disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range;
(b) receiving, using such plurality of devices being disposed to surround at least a portion of such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of devices; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume.
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72. Method for detection and characterization of a medical pathology within an object under study, comprising the steps of:
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(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range;
(b) receiving, using at least 5,000 radiation detectors being disposed to surround at least a portion of such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said at least 5,000 radiation detectors; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume.
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73. Method for detection and characterization of a medical pathology within an object under study, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound devices disposed so as to be capable of insonifying such object, upon a volume within the object under study with ultrasound radiation within a predetermined frequency range;
(b) receiving, using such plurality of ultrasound devices being to surround a least a portion of such object, ultrasound radiation scattered by said volume within the object and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound devices; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume.
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74. Method for detection and characterization of a medical pathology within a human breast, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such human breast, upon a volume within the human breast with ultrasound radiation within a predetermined frequency range;
(b) receiving, using a plurality of ultrasound radiation detectors being disposed to surround a least a portion of such human breast, ultrasound radiation scattered by said volume within the human breast and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and
(d) detecting and characterizing such medical pathology within said volume using said multidimensional field rendering of said volume.
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75. Method for detection and characterization of cancer within biological tissue, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such biological tissue, upon a volume within the biological tissue with ultrasound radiation within a predetermined frequency range;
(b) receiving, using a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue, ultrasound radiation scattered by said volume within the biological tissue and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and
(d) detecting and characterizing such cancer within said volume using said multidimensional field rendering of said volume.
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76. Method for detection and characterization of cancer within biological tissue, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such biological tissue, upon a volume within the biological tissue with ultrasound radiation within a predetermined frequency range;
(b) receiving, using a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue, ultrasound radiation scattered by said volume within the biological tissue and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and
(d) detecting and characterizing such cancer within said volume using an expert system to analyze said multidimensional field rendering of said volume.
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77. Method for detection and characterization of cancer within biological tissue, comprising the steps of:
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(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such biological tissue, upon a volume within the biological tissue with ultrasound radiation within a predetermined frequency range;
(b) receiving, using a plurality of ultrasound radiation detectors being disposed to surround at least a portion of such biological tissue, ultrasound radiation scattered by said volume within the biological tissue and providing data corresponding to the ultrasound radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and
(d) detecting and characterizing such cancer within said volume using a neural net to analyze said multidimensional field rendering of said volume.
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78. Apparatus for detection and characterization of a distinct feature within an object under study, comprising:
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(a) a radiation source adapted to emit radiation within a predetermined frequency range onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;
(b) a plurality of radiation detectors being disposed to surround at least a portion of such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;
(c) means for controlling said radiation source and said plurality of radiation detectors to emit and receive radiation; and
(d) a device coupled to said plurality of radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such distinct feature within said volume.
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79. Method for detection and characterization of a distinct feature within an object under study, comprising the steps of:
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(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range;
(b) receiving, using a plurality of radiation detectors being disposed to surround at least a portion of such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;
(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of detectors; and
(d) detecting and characterizing such distinct feature within said volume using said multidimensional field rendering of said volume.
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Specification