Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing
First Claim
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1. An osmotic dosage form adapted to release reboxetine at a uniform rate comprising:
- a. a semipermeable membrane defining an internal compartment;
b. an osmotic composition component comprising reboxetine and a carbohydrate within the internal compartment; and
c. a delivery orifice formed or formable in the semipermeable membrane through which the reboxetine is delivered.
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Abstract
Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
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Citations
21 Claims
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1. An osmotic dosage form adapted to release reboxetine at a uniform rate comprising:
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a. a semipermeable membrane defining an internal compartment;
b. an osmotic composition component comprising reboxetine and a carbohydrate within the internal compartment; and
c. a delivery orifice formed or formable in the semipermeable membrane through which the reboxetine is delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 18, 19, 20, 21)
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9. A method of treating a condition in a subject responsive to reboxetine, the method comprising orally administering to the subject an osmotic dosage form adapted to release reboxetine at a uniform rate comprising:
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a. a semipermeable membrane defining an Internal compartment;
b. an osmotic composition component comprising reboxetine and a carbohydrate within the internal compartment; and
c. a delivery orifice formed or formable in the semipermeable membrane through which the reboxetine is delivered. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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Specification