Anti-factor IX/IXa antibodies
First Claim
Patent Images
1. An altered antibody comprising a heavy chain and a light chain, wherein the framework regions of said heavy and light chains are derived from at least one selected antibody and the amino acid sequences of the heavy chain complementarity determining regions (CDRs) are as set forth in SEQ ID NOs:
- 8, 9 and 10 and the amino acid sequences of the light chain CDRs are as set forth in SEQ ID NOs;
12, 13 and 14.
1 Assignment
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Accused Products
Abstract
Monoclonal antibodies directed against coagulation factors and their use in inhibiting thrombosis are disclosed.
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Citations
13 Claims
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1. An altered antibody comprising a heavy chain and a light chain, wherein the framework regions of said heavy and light chains are derived from at least one selected antibody and the amino acid sequences of the heavy chain complementarity determining regions (CDRs) are as set forth in SEQ ID NOs:
- 8, 9 and 10 and the amino acid sequences of the light chain CDRs are as set forth in SEQ ID NOs;
12, 13 and 14. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- 8, 9 and 10 and the amino acid sequences of the light chain CDRs are as set forth in SEQ ID NOs;
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13. A humanized antibody comprising a heavy chain having the amino acid sequence set forth in SEQ ID NO:
- 52 and a light chain having the amino acid sequence set forth in SEQ ID NO;
74.
- 52 and a light chain having the amino acid sequence set forth in SEQ ID NO;
Specification