Stabilization of implantable bioprosthetic tissue
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1. An implantable bioprosthesis comprising proteins cross-linked with a poly-(2-hydroxyorgano)amino moiety.
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Abstract
The invention relates to implantable bioprostheses (e.g. implantable biological tissues) and to compositions and methods for stabilizing them. Implantable bioprostheses stabilized as described herein exhibit improved mechanical properties and reduced post-implantation calcification. The implantable bioprosthesis is made by contacting a bioprosthesis (e.g. a tissue obtained from an animal or an article comprising a tissue and a synthetic material) with a polyepoxy amine compound.
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15 Claims
- 1. An implantable bioprosthesis comprising proteins cross-linked with a poly-(2-hydroxyorgano)amino moiety.
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