System for control of blood processor

• US 6,393,369 B1
• Filed: 04/30/1999
• Issued: 05/21/2002
• Est. Priority Date: 04/30/1999
• Status: Expired due to Fees

• Current Assignee: Vivolution A/S
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Carr, Raymond A.
• Primary Examiner(s): WACHSMAN, HAL D
• Application Number:
  US09/302,487
• Publication Number:
  US 20020077758A1
• Time in Patent Office: 1,117 Days
• Field of Search: 702/50, 702/19, 702/21-23, 702/45, 702/25-27, 702/29-32, 702/46, 702/55, 702/113, 702/114, 702/122, 702/123, 702/183, 702/188, 702/FOR.120, 702/FOR.17, 702/FOR.127, 702/FOR.128, 702/FOR.134, 702/FOR.103, 702/FOR.104, 702/FOR-115, 702/FOR.121, 700/2, 700/3, 700/9, 700/10, 700/86, 700/87, 700/266-269, 700/271, 700/273, 700/275, 700/282, 700/283, 700/285, 210/781, 210/782, 210/787, 210/789, 210/198.1, 210/206, 210/209, 210/360.1, 210/380.1, 210/210, 210/645, 210/141-143, 210/145, 494/7-9, 494/10, 494/11, 494/27, 494/43, 494/35-37, 494/41, 422/72, 422/73, 422/101, 422/68.1, 422/67, 422/50, 422/55-57, 422/62, 422/82, 422/82.05, 422/82.09, 436/177, 436/45, 436/66, 436/43, 604/4.01, 604/5.01, 604/6-1-, 530/382, 530/381, 435/13
• US Class Current: 702/50
• CPC Class Codes: B04B 13/00 Control arrangements specially designed for centrifuges; Programme control of centrifuges control arrangements for feed, charge, or discharge B04B11/00
• CPC Class Codes: B04B 2005/0485 with a displaceable piston in the centrifuge chamber
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation

Abstract

A blood processor is provided with a computer and memory, and external to the blood processor there is provided a general purpose computer system programmed with a convenient interface for creating scripts; the general purpose computer system translates the scripts into custom interpretive code adapted for processing by the computer in the blood processor, and the code is written into the memory of the blood processor via the computer in the blood processor.

Claims

1. A system for controlling a blood processor, comprising:

a blood processor with a microprocessor and memory; and

an external computer having a user interface and a script generator;

said blood processor having a plurality of devices, each with one or more respective operations;

said script generator including device information and operation information relating to said plurality of devices and said one or more respective operations;

said user interface being adapted to display said device information and said operation information;

said external computer recording a selected set of steps indicating selected ones of said one or more respective operations for said plurality of devices;

said script generator outputting, as a script, said selected set of steps in a custom interpretive language readable by said microprocessor of said blood processor; and

said script being loaded into said memory of said blood processor;

wherein said selected set of steps include;

spinning whole blood in a first chamber to separate plasma from cells;

moving a piston of a preparation unit to draw plasma from said first chamber to a second chamber;

mixing said plasma in said second chamber with an enzyme which converts fibrinogen in said plasma into a fibrin polymer;

releasing a dissolving buffer into said second chamber from a liquid container;

rotating said preparation unit in alternate directions to dissolve said fibrin polymer in said dissolving buffer forming a fibrin monomer solution;

releasing an enzyme capture reagent into said second chamber;

manipulating said preparation unit so that said fibrin monomer solution flows into a third chamber of said preparation unit;

rotating said preparation unit so that said fibrin monomer solution flows through an annular filter into a fourth chamber of said preparation unit; and

transferring said fibrin monomer solution into said liquid container; and

wherein;

said preparation unit has an indicator;

said memory of said blood processor includes said script and a different script, defining a plurality of scripts;

said blood processor includes a reader reading said indicator of said preparation unit and providing to said microprocessor an indication based on said reading of said indicator; and

said microprocessor selecting one of said plurality of scripts based on said indication.

2. The system for controlling the blood processor as set forth in claim 1, wherein said reader is a bar code reader.

3. A system for controlling a blood processor, comprising:

a blood processor having at least one device, a memory, and a microprocessor for controlling said at least one device in accordance with a script stored in said memory;

an external computer having a user interface and having a script generator for generating said script, in a custom interpretive language readable by said microprocessor of said blood processor, in accordance with user input through said user interface; and

an interface, for transferring said script to said memory, said interface being contained at least partially in said blood processor, or said external computer, or both said blood processor and said external computer;

wherein;

said at least one device has one or more respective operations;

said script generator includes device information and operation information relating to said at least one device and said one or more respective operations;

said user interface is adapted to display said device information and said operation information; and

said external computer generates said script by;

recording a selected set of steps indicating selected ones of said one or more respective operations for said at least one device, and

outputting said selected set of steps as said script in said custom interpretive language; and

wherein said selected set of steps includes;

a step for separating plasma from cells;

a step for converting fibrinogen in said plasma into a fibrin polymer;

a step for forming a fibrin monomer solution from said fibrin polymer; and

a step for transferring said fibrin monomer solution into a liquid container;

wherein;

said step for separating said plasma from said cells comprises spinning whole blood in a first chamber, and moving a piston of a preparation unit to draw said plasma from said first chamber to a second chamber;

said step for converting said fibrinogen into said fibrin polymer comprises mixing said plasma in said second chamber with an enzyme that converts said fibrinogen in said plasma into said fibrin polymer;

said step for forming said fibrin monomer solution from said fibrin polymer comprises releasing a dissolving buffer into said second chamber from said liquid container, and rotating said preparation unit in alternate directions to dissolve said fibrin polymer in said dissolving buffer so as to form said fibrin monomer solution; and

said step for transferring said fibrin monomer solution into said liquid container comprises releasing an enzyme capture reagent into said second chamber, manipulating said preparation unit so that said fibrin monomer solution flows into a third chamber of said preparation unit, rotating said preparation unit so that said fibrin monomer solution flows through an annular filter into a fourth chamber of said preparation unit, and then drawing said fibrin monomer solution into said liquid container; and

wherein;

said preparation unit has an indicator;

said memory of said blood processor includes said script and a different script, defining a plurality of scripts;

said blood processor includes a reader reading said indicator of said preparation unit and providing to said microprocessor an indication based on said reading of said indicator; and

said microprocessor selecting one of said plurality of scripts based on said indication.

4. A system for controlling a blood processor, comprising:

a blood processor having at least one device, a memory, and a microprocessor for controlling said at least one device in accordance with a script stored in said memory;

an external computer having a user interface and having a script generator for generating said script, in a custom interpretive language readable by said microprocessor of said blood processor, in accordance with user input through said user interface; and

an interface, for transferring said script to said memory, said interface being contained at least partially in said blood processor, or said external computer, or both said blood processor and said external computer;

wherein;

said at least one device has one or more respective operations;

said script generator includes device information and operation information relating to said at least one device and said one or more respective operations;

said user interface is adapted to display said device information and said operation information; and

said external computer generates said script by;

recording a selected set of steps indicating selected ones of said one or more respective operations for said at least one device, and

outputting said selected set of steps as said script in said custom interpretive language; and

wherein;

said selected set of steps includes one or more steps for processing blood using a preparation unit;

said preparation unit has an indicator;

said memory of said blood processor includes said script and a different script, defining a plurality of scripts;

said blood processor includes a reader reading said indicator of said preparation unit and providing to said microprocessor an indication based on said reading of said indicator; and

said microprocessor selects one of said plurality of scripts based on said indication.

5. The system for controlling the blood processor as set forth in claim 4, wherein said reader is a bar code reader.

6. The system for controlling the blood processor as set forth in claim 4, wherein said steps for processing said blood using said preparation unit include:

a step for separating plasma from cells in said preparation unit;

a step for converting fibrinogen in said plasma into a fibrin polymer;

a step for forming a fibrin monomer solution from said fibrin polymer; and

a step for transferring said fibrin monomer solution from said preparation unit into a liquid container.

7. The system for controlling the blood processor as set forth in claim 6, wherein:

said step for separating said plasma from said cells comprises spinning whole blood in a first chamber, and moving a piston of said preparation unit to draw said plasma from said first chamber to a second chamber;

said step for converting said fibrinogen into said fibrin polymer comprises mixing said plasma in said second chamber with an enzyme that converts said fibrinogen in said plasma into said fibrin polymer;

said step for forming said fibrin monomer solution from said fibrin polymer comprises releasing a dissolving buffer into said second chamber from said liquid container, and rotating said preparation unit in alternate directions to dissolve said fibrin polymer in said dissolving buffer so as to form said fibrin monomer solution; and

said step for transferring said fibrin monomer solution into said liquid container comprises releasing an enzyme capture reagent into said second chamber, manipulating said preparation unit so that said fibrin monomer solution flows into a third chamber of said preparation unit, rotating said preparation unit so that said fibrin monomer solution flows through an annular filter into a fourth chamber of said preparation unit, and then drawing said fibrin monomer solution into said liquid container.

8. A system for controlling a blood processor, comprising:

a blood processor with a microprocessor and memory; and

an external computer having a user interface and a script generator;

said blood processor having a plurality of devices, each with one or more respective operations;

said script generator including device information and operation information relating to said plurality of devices and said one or more respective operations;

said user interface being adapted to display said device information and said operation information;

said external computer recording a selected set of steps indicating selected ones of said one or more respective operations for said plurality of devices;

said script generator outputting, as a script, said selected set of steps in a custom interpretive language readable by said microprocessor of said blood processor; and

said script being loaded into said memory of said blood processor

wherein;

said selected set of steps includes one or more steps for processing blood using a preparation unit;

said preparation unit has an indicator;

said memory of said blood processor includes said script and a different script, defining a plurality of scripts;

said blood processor includes a reader reading said indicator of said preparation unit and providing to said microprocessor an indication based on said reading of said indicator; and

said microprocessor selects one of said plurality of scripts based on said indication.

9. The system for controlling the blood processor as set forth in claim 8, wherein said reader is a bar code reader.

10. The system for controlling the blood processor as set forth in claim 8, wherein said steps for processing said blood using said preparation unit include:

a step for separating plasma from cells in said preparation unit;

a step for converting fibrinogen in said plasma into a fibrin polymer;

a step for forming a fibrin monomer solution from said fibrin polymer; and

a step for transferring said fibrin monomer solution from said preparation unit into a liquid container.

11. The system for controlling the blood processor as set forth in claim 10, wherein:

said step for separating said plasma from said cells comprises spinning whole blood in a first chamber, and moving a piston of said preparation unit to draw said plasma from said first chamber to a second chamber;

said step for converting said fibrinogen into said fibrin polymer comprises mixing said plasma in said second chamber with an enzyme that converts said fibrinogen in said plasma into said fibrin polymer;

said step for forming said fibrin monomer solution from said fibrin polymer comprises releasing a dissolving buffer into said second chamber from said liquid container, and rotating said preparation unit in alternate directions to dissolve said fibrin polymer in said dissolving buffer so as to form said fibrin monomer solution; and

said step for transferring said fibrin monomer solution into said liquid container comprises releasing an enzyme capture reagent into said second chamber, manipulating said preparation unit so that said fibrin monomer solution flows into a third chamber of said preparation unit, rotating said preparation unit so that said fibrin monomer solution flows through an annular filter into a fourth chamber of said preparation unit, and then drawing said fibrin monomer solution into said liquid container.