Method of treating a heart using cells irradiated in vitro with biostimulatory irradiation

• US 6,395,016 B1
• Filed: 07/07/2000
• Issued: 05/28/2002
• Est. Priority Date: 07/28/1996
• Status: Expired due to Term

• Current Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Original Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Inventors: Matcovitch, Avraham, Oron, Uri
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): VRETTAKOS, PETER J
• Application Number:
  US09/612,584
• Time in Patent Office: 690 Days
• Field of Search: 607/88-92,50,3 606/2,9,10,13-17 424/93 600/407
• US Class Current: 607/88
• CPC Class Codes: A61B 1/0051 with controlled bending of insertion part
• CPC Class Codes: A61B 1/0056 the insertion parts being asymmetric, e.g. for unilateral bending mechanisms
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2017/00039 Electric or electromagnetic phenomena other than conductivity, e.g. capacity, inductivity, Hall effect
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2018/2211 Plurality of fibres
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/363 Use of fiducial points
• CPC Class Codes: A61B 2090/374 : NMR or MRI
• CPC Class Codes: A61B 2090/378 : using ultrasound
• CPC Class Codes: A61B 2090/3954 : magnetic, e.g. NMR or MRI
• CPC Class Codes: A61B 34/20 : Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/06 : Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/061 : Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/287 : Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6885 : Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 8/0833 : involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/0841 : for locating instruments
• CPC Class Codes: A61B 8/12 : in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61M 2025/0166 : Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
• CPC Class Codes: A61M 25/01 : Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0105 : Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61M 25/104 : used for angioplasty
• CPC Class Codes: A61N 1/05 : for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 2005/0659 : infrared
• CPC Class Codes: A61N 5/0601 : Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent

Abstract

A method of treating a patient'"'"'s heart comprises the steps of identifying an ischemic area of the heart. A plurality of cells are provided and the cells are irradiated in vitro with electromagnetic radiation. The irradiated cells are then implanted into the ischemic area of the heart. The electromagnetic radiation provides biostimulation of the cells. The treated cells are cardio myocetes such as from embrionic heart muscle or skeletal muscle cells. The electromagnetic radiation is in the infrared (IR) range, visible light range, or ultraviolet (UV) range.

Claims

1. A method of treating a heart comprising the steps of:

identifying an ischemic area of the heart;

providing a plurality of cells;

irradiating the cells in vitro with electromagnetic radiation; and

implanting the irradiated cells into the ischemic area of the heart.

2. The method according to claim 1, wherein the electromagnetic radiation provides biostimulation of the cells.

3. The method according to claim 2, wherein the cells are cardiomyocytes.

4. The method according to claim 3, wherein the cardiomyocytes are from embryonic heart muscle.

5. The method according to claim 2, wherein the cells are skeletal muscle cells.

6. The method according to claim 2, wherein the electromagnetic radiation is in the infrared (IR) range.

7. The method according to claim 2, wherein the electromagnetic radiation is in the visible light range.

8. The method according to claim 2, wherein the electromagnetic radiation is in the ultraviolet (UV) range.