Matrices for drug delivery and methods for making and using the same
First Claim
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1. A method for producing a biologically active agent from a prodrug, comprising:
- a. encapsulating a first cell-free reaction center in a biocompatible matrix; and
b. administering said biocompatible matrix to a subject;
wherein said biocompatible matrix comprises an inorganic-based sol-gel matrix and wherein said first reaction center converts a first prodrug into a first biologically active agent in said subject.
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Abstract
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme
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Citations
140 Claims
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1. A method for producing a biologically active agent from a prodrug, comprising:
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a. encapsulating a first cell-free reaction center in a biocompatible matrix; and
b. administering said biocompatible matrix to a subject;
wherein said biocompatible matrix comprises an inorganic-based sol-gel matrix and wherein said first reaction center converts a first prodrug into a first biologically active agent in said subject.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
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70. A biocompatible matrix for treatment, comprising:
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a. a inorganic-based sol-gel matrix that is biocompatible; and
,b. a first cell-free reaction center encapsulated in said matrix, wherein said first reaction center, after administration of said matrix to a subject, produces a therapeutically effective amount of a first biologically active agent from a first prodrug in said subject. - View Dependent Claims (71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112)
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113. A biologically active agent produced by a process comprising:
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a. encapsulating a first cell-free reaction center in a biocompatible matrix; and
b. administering said biocompatible matrix to a subject;
wherein said biocompatible matrix comprises an inorganic-based sol-gel matrix, and wherein said biologically active agent is produced by said first reaction center from a first prodrug in said subject.- View Dependent Claims (114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130)
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131. A kit for treatment of a subject, comprising:
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a. a inorganic-based sol-gel matrix that is biocompatible; and
,b. a first cell-free reaction center encapsulated in said matrix, wherein said first reaction center, after administration of said matrix to a subject, produces a therapeutically effective amount of a first biologically active agent from a first prodrug in said subject. - View Dependent Claims (132, 133, 134, 135, 136, 137, 138)
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139. A method of treatment of a subject, comprising:
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a. a step for encapsulating a first cell-free reaction center in a biocompatible matrix; and
b. a step for administering said biocompatible matrix to a subject;
wherein said biocompatible matrix comprises a silica-based sol-gel matrix, and wherein said first reaction center converts a first prodrug into a first biologically active agent in said subject.- View Dependent Claims (140)
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Specification