Non-invasive carboxyhemoglobin analyzer
DCFirst Claim
1. A non-invasive method for measuring the relative concentration or percentage of carboxyhemoglobin in a subject'"'"'s blood, said method comprising the steps of:
- a. directing light at a first pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected;
b. directing light at a second pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the second pair differing from the wavelengths of the first pair;
c. simultaneously determining the pulsatile changes in absorbance of the first and second pairs of wavelengths of light by the subject'"'"'s arterial blood;
d. determining the ratio of change in absorbance of each of the first and second pairs of wavelengths, and;
e. calculating the concentration of carboxyhemoglobin in said subject'"'"'s blood by comparing the results of a formula employing the ratios determined in step d as independent variables to the results of the same formula in subjects with known carboxyhemoglobin levels.
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Abstract
An apparatus and method is disclosed which allows the non-invasive monitoring of a subject'"'"'s carboxyhemoglobin level, thereby allowing the detection of possible carbon monoxide poisoning. The subject breathes oxygen to saturate his blood hemoglobin and eliminate reduced hemoglobin, thus allowing the detection and differentiation between oxy- and carboxyhemoglobin by modification of a conventional pulse oximeter. Preferably the device works in two modes. The first mode is a conventional pulse oximeter capable of determining the level of oxy-hemoglobin in the subject'"'"'s arterial blood. Upon the achievement of certain criteria the preferred embodiment of the inventive device would switch to a second mode, in which mode the device would be capable of determining carboxyhemoglobin levels. Alternatively, carboxyhemoglobin can be measured using two devices and two different pairs of wavelengths transilluminating two different body parts.
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Citations
9 Claims
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1. A non-invasive method for measuring the relative concentration or percentage of carboxyhemoglobin in a subject'"'"'s blood, said method comprising the steps of:
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a. directing light at a first pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected;
b. directing light at a second pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the second pair differing from the wavelengths of the first pair;
c. simultaneously determining the pulsatile changes in absorbance of the first and second pairs of wavelengths of light by the subject'"'"'s arterial blood;
d. determining the ratio of change in absorbance of each of the first and second pairs of wavelengths, and;
e. calculating the concentration of carboxyhemoglobin in said subject'"'"'s blood by comparing the results of a formula employing the ratios determined in step d as independent variables to the results of the same formula in subjects with known carboxyhemoglobin levels. - View Dependent Claims (2, 3, 4, 5)
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6. A non-invasive method for measuring the concentrations of carboxyhemoglobin and met-hemoglobin in a subject'"'"'s blood, said method comprising the steps of:
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a. directing light at a first pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected;
b. directing light at a second pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the second pair differing from the wavelengths of the first pair;
c. directing light at a third pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the third pair differing from the wavelengths of the first and second pairs;
d. simultaneously determining the pulsatile changes in absorbance of the first, second and third pairs of wavelengths of light by the subject'"'"'s arterial blood;
e. determining the ratio of change in absorbance of each of the first, second and third pairs of wavelengths, and;
f. calculating the concentrations of carboxy-hemoglobin and met-hemoglobin in said subject'"'"'s blood by comparing the results of a formula employing the ratios determined in step e as independent variables to the same ratios determined in subjects with known carboxyhemoglobin and met-hemoglobin levels. - View Dependent Claims (7, 8)
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9. A non-invasive method for measuring the concentration of oxy-hemoglobin while accounting for the relative concentration of met-hemoglobin and/or carboxyhemoglobin in a subject'"'"'s blood, said method comprising the steps of:
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a. directing light at a first pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected;
b. directing light at a second pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the second pair differing from the wavelengths of the first pair;
c. directing light at a third pair of two different wavelengths through tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, at least one of the wavelengths of the third pair differing from the wavelengths of the first and second pairs;
d. simultaneously determining the pulsatile changes in absorbance of the first, second and third pairs of wavelengths of light by the subject'"'"'s arterial blood;
e. determining the ratio of change in absorbance of each of the first, second and third pairs of wavelengths, and;
f. calculating the relative concentrations of oxy-hemoglobin and carboxyhemoglobin and/or met-hemoglobin in said subject'"'"'s blood by comparing the results of a formula employing the ratios determined in step e as independent variables to the results of the same formula in subjects with known oxy-hemoglobin, carboxyhemoglobin, and met-hemoglobin levels.
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Specification