Method and control apparatus for tracking a contrast agent in an examination subject using a medical imaging device

• US 6,397,097 B1
• Filed: 03/16/1999
• Issued: 05/28/2002
• Est. Priority Date: 03/16/1998
• Status: Expired due to Fees

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Requardt, Martin
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US09/268,776
• Time in Patent Office: 1,169 Days
• Field of Search: 600/410,413,419,420,431 324/306,309 378/4
• US Class Current: 600/431
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

In a method and control apparatus for tracking a contrast agent using an imaging medical device a test bolus of a contrast agent is initially injected into an examination subject, followed by an injection of a main bolus at a time interval of Δti. The arrival of the test bolus in the observation volume is chronologically determined by periodically repeated survey measurements. An image data measurement is started at a time interval Δtm subsequent to the detection of the test bolus, this time interval Δtm being defined according to the prescribed time interval Δti.

Claims

1. A method for tracking a contrast agent in an examination subject, comprising the steps of:

disposing an examination subject in a medical imaging apparatus;

injecting a test bolus of a contrast agent into said examination subject;

subsequently injecting a liquid into said examination subject which is free of contrast agent;

subsequently injecting a main bolus of contrast agent into said examination subject at a predetermined time interval Δ

ti following injection of said test bolus so that said test bolus, said liquid and said main bolus are injected in immediate succession;

monitoring an arrival of said test bolus within an observation volume of said examination subject by periodically and repeatedly obtaining survey images of said observation volume of said examination subject using said medical imaging apparatus; and

subsequent to identifying the arrival of said test bolus in said observation volume, beginning data acquisition for a diagnostic image of said examination subject using said medical imaging apparatus for a time interval Δ

tm, and selecting Δ

tm dependent on said predetermined time interval Δ

ti.

2. A method as claimed in claim 1 wherein the step of periodically and repeatedly obtaining said survey images comprises periodically and repeatedly obtaining survey images with a low spatial resolution.

3. A method as claimed in claim 2 wherein the step of periodically and repeatedly obtaining said survey images with a low spatial resolution comprises periodically and repeatedly obtaining said survey images with a spatial resolution in only one direction.

4. A method as claimed in claim 3 wherein said test bolus has a substantially smaller volume than said main bolus of contrast agent.

5. A method as claimed in claim 1 wherein the step of starting acquisition of data for said diagnostic image comprises automatically starting acquisition of data for said diagnostic image.

6. A method as claimed in claim 1 wherein the step of disposing said examination subject in a medical imaging apparatus comprises disposing said examination subject in a magnetic resonance imaging apparatus, and wherein the step of acquiring said data for said diagnostic image comprises acquiring frequency-coded and phase-coded nuclear resonance signals, and comprising the additional step of sorting said nuclear resonance signals into a k-space matrix ordered by respective phase factors of said nuclear resonant signals, and wherein the step of selecting said time Δ

tm comprises selecting Δ

tm so that a central region of k-space is measured while a maximum contrast agent concentration is present in said observation volume.

7. A method as claimed in claim 1 wherein the step of disposing an examination subject in a medical imaging apparatus comprises disposing said examination subject in a magnetic resonance imaging apparatus, and wherein the step of acquiring data for a diagnostic image comprises acquiring magnetic resonance imaging data for producing a magnetic resonance image.

8. A method as claimed in claim 1 wherein the step of disposing an examination subject in a medical imaging apparatus comprises disposing said examination subject in a computed tomography apparatus, and wherein the step of acquiring data for a diagnostic image comprises acquiring radiographic data for producing a computed tomographic image.

9. A method as claimed in claim 1 wherein said test bolus has a circulation time in said examination subject associated therewith, and wherein the step of subsequently injecting said main bolus of contrast agent comprises selecting said predetermined time interval Δ

ti to be less than said circulation time.

10. In a medical imaging apparatus wherein image data are acquired and wherein a diagnostic image is produced from said image data, the improvement of a control apparatus for tracking a contrast agent in said examination subject comprising:

a first infusion pump adapted for connection to an examination subject for infusing a contrast agent into said examination subject;

a second infusion pump for infusing a liquid into said examination subject which is free of contrast agent;

a controller connected to said first infusion pump and to said second infusion pump, said controller operating said first infusion pump to inject a first contrast agent bolus into said examination subject followed at a predetermined time interval Δ

ti by injection of a second contrast agent bolus into said examination subject, with an injection of said liquid which is free of contrast agent from said second infusion pump during said interval Δ

ti, so that said first contrast agent bolus, said liquid and said second contrast agent bolus are injected in immediate succession;

said controller having an input for receiving a status signal from said medical imaging apparatus indicating arrival of said first bolus of contrast agent in an examination volume; and

said controller having a control output for starting image data acquisition by said medical imaging apparatus at a time interval Δ

tm after receiving said status signal, with Δ

tm being determined dependent on said time interval Δ

ti.

11. A medical imaging apparatus as claimed in claim 10 wherein said first contrast agent bolus has a circulation time in said examination subject associated therewith, and wherein said controller injects said second contrast agent at said predetermined time interval Δ

ti which is less than said circulation time.

12. The improvement of claim 11 further comprising a message output at said controller activated at a predetermined amount of time subsequent to reception of said status signal, but before an end of said time interval Δ

tm.

13. The improvement of claim 11 wherein said controller includes means for adjusting a volume of each of said first bolus and said second bolus infused by said first infusion pump.