×

Intermediates for the synthesis of vitamin D and steroid derivatives and process for preparation thereof

  • US 6,399,767 B1
  • Filed: 05/22/2000
  • Issued: 06/04/2002
  • Est. Priority Date: 09/03/1996
  • Status: Expired due to Term
First Claim
Patent Images

1. A process for preparing a compound having the structure:

  • embedded imagewherein n is an integer from 1-5;

    each of R1 and R2 independently is optionally substituted C1-C6 alkyl;

    each of W and X is independently hydrogen or C1-C6 alkyl;

    Y is O, S or NR3 where R3 is hydrogen, C1-C6 alkyl or a protective group; and

    Z is a CD ring structure of the formula embedded imagea steroid ring structure of the formula embedded imageor a vitamin D structure of the formula embedded imagewherein each of the structures of Z optionally have one or more protected or unprotected substituents and/or one or more protective groups, and wherein any ring of the structure of Z may optionally have one or more unsaturated bonds;

    which comprises;

    a) reacting a compound having the structure;

    embedded image

    wherein W, X, Y and Z are as defined above, in the presence of a base, with a compound having the structure;

    embedded image

    wherein n, R1 and R2 are as defined above, and E is an eliminating group, to produce the compound; and

    b) recovering the compound so produced.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×