Means and method for the treatment of migraine headaches

• US 6,402,678 B1
• Filed: 07/31/2000
• Issued: 06/11/2002
• Est. Priority Date: 07/31/2000
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuralieve, Inc.
• Inventors: Fischell, David R., Fischell, Robert E., Upton, Adrian R. M.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): Cadugan, Joseph A
• Application Number:
  US09/629,210
• Time in Patent Office: 680 Days
• Field of Search: 600/9-15
• US Class Current: 600/13
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Disclosed is a means and method for the treatment of migraine headaches. Patients who have migraine headaches typically have a band of excited brain neurons that are a precursor of the headache. By placing an intense alternating magnetic field onto a certain region of the brain, an electrical current can be generated in the cerebral cortex that can depolarize these excited brain neurons. This procedure can stop a migraine headache in some patients or at least decrease its severity. The device to perform this function can be called a “magnetic depolarizer”. The magnetic depolarizer can be placed in some headgear such as a bicycle helmet in order to place the magnetic field at the correct location relative to the patient'"'"'s cerebral cortex. This technique can be particularly valuable for patients who have a perceptible aura that occurs prior to the onset of a migraine headache. A visual aura caused by the progression of an excited band of neurons in a patient'"'"'s occipital lobe, which aura occurs 20 to 30 minutes prior to the onset of head pain, would be particularly well treated by means of the magnetic depolarizer.

Claims

1. A magnetic depolarizer system for the treatment of migraine headache, the system including:

a readily portable magnetic depolarizer adapted for placement by a human patient at a specific location on his or her head, the specific location being a region where the application of a time varying magnetic field will decrease the intensity and/or duration of a migraine headache, the magnetic depolarizer having at least one electromagnetic coil that is capable of providing the time varying magnetic field with a peak intensity at some portion of the patient'"'"'s cerebral cortex of at least 0.1 Tesla;

electrical circuitry connected to the magnetic depolarizer for providing an electrical current through the at least one electromagnetic coil, the electrical circuitry also including a patient operated switch for turning on the magnetic depolarizer system; and

,

a positioner adapted for placement of the magnetic depolarizer system by the human patient onto the specific location of his or her head.

2. The system of claim 1 wherein the electrical circuitry of the magnetic depolarizer system includes a battery.

3. The system of claim 2 wherein the battery is rechargeable.

4. The system of claim 1 wherein the magnetic depolarizer utilizes two coils, in a race-track, figure-eight configuration.

5. The system of claim 1 wherein the magnetic depolarizer utilizes ferromagnetic cores to decrease the amount of electric current required to provide a specific magnetic field intensity.

6. The system of claim 1 wherein the electronic circuitry is adapted to deliver at least one time varying magnetic pulse.

7. The system of claim 6 wherein the length of the magnetic pulse is between approximately 1 microsecond and approximately 1,000 microseconds.

8. The system of claim 6 wherein the electronic circuitry is adapted to deliver a sequence of pulses comprising a plurality of time varying magnetic pulses, and wherein the magnetic pulses are delivered at a rate of between approximately 0.1 Hz and approximately 1,000 Hz.

9. The system of claim 8 wherein the sequence of pulses is delivered over a time period of between approximately 0.1 second and approximately 100 seconds.

10. The system of claim 1 wherein the positioner comprises a headgear adapted to accurately place the magnetic depolarizer at a specific location on the head of the human being.

11. The system of claim 10 wherein the headgear comprises a helmet of the type worn by bicycle riders.

12. The system of claim 10 wherein the headgear comprises at least one elastic band.

13. The system of claim 1, wherein the electrical circuitry also includes at least one operating parameter that is preset by a physician.

14. A magnetic depolarizer system for the treatment of a migraine headache of a human patient, the system including:

a readily portable magnetic depolarizer adapted for placement by the human patient at a specific location on his or her head, the specific location being a region where the application of a time varying magnetic field will decrease the intensity and/or duration of a migraine headache, the magnetic depolarizer being capable of providing the time varying magnetic field with a peak intensity at some portion of the patient'"'"'s cerebral cortex of at least 0.1 Tesla; and

a patient-operated switch for activating the magnetic depolarizer, the switch being attached to the magnetic depolarizer at a position where it is readily operable by the human patient.

15. A method for the treatment of migraine headaches, the method comprising the following steps:

(a) sensing of an aura of a migraine headache by a migraine patient; and

(b) placing a magnetic depolarizer onto the head of the patient at a location where the magnetic depolarizer can create depolarization of the neurons that are the cause of the aura.

16. The method of claim 15 further comprising the step of turning the magnetic depolarizer on so as to create at least one alternating magnetic field pulse onto the patient'"'"'s cerebral cortex.

17. The method of claim 15 further comprising the step of applying magnetic pulses at a rate between approximately 0.1 Hz and approximately 1,000 Hz.

18. The method of claim 15 further comprising the step of applying a sequence of magnetic pulses for a time period between approximately 0.1 second and approximately 100 seconds.

19. The method of claim 15 further comprising the step of applying at least one magnetic pulse having a duration between approximately 10 microseconds and approximately 1,000 microseconds.

20. The method of claim 15 further comprising the step of powering the magnetic depolarizer by means of a rechargeable battery.

21. The method of claim 15 further comprising the step of turning an ON-OFF switch by the patient first to the ON position and then to the OFF position.

22. The method of claim 15 further comprising the step of having the patient turn the ON-OFF switch to the ON position and then having the magnetic depolarizer system automatically turn the system off after a preset time period.

23. The method of claim 15 further comprising the step of having a physician set at least one operating parameter of the system.

24. A method for treating a migraine headache in a human patient with a readily portable magnetic depolarizer, the method including the steps of:

detecting an occurrence of an onset of a migraine headache by the human patient;

having the human patient place the magnetic depolarizer onto his or her head;

activating the magnetic depolarizer by having the human patient turn on the magnetic depolarizer using a switch that is attached to the magnetic depolarizer; and

generating a time-varying magnetic field having a peak intensity at some portion of the patient'"'"'s cerebral cortex of at least 0.1 Tesla.

25. The method of claim 24, wherein the step of detecting an occurrence of an onset of a migraine headache comprises receiving an input from the patient.