Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
First Claim
1. A method of monitoring and evaluating the status of a tumor undergoing treatment, comprising the steps of:
- (a) monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment with an in situ sensor unit;
(b) transmitting data associated with the at least one monitored physiological parameter from the in situ positioned sensor unit to a receiver located external to the subject;
(c) analyzing the transmitted data to determine a condition of the tumor;
(d) repeating steps (a), (b), and (c) periodically at a plurality of sequential points in time; and
(e) evaluating a tumor treatment strategy comprising at least one of;
identifying a favorable or unfavorable tumor treatment time for administration of at least one of a radiation, drug, and chemical therapy;
evaluating the efficacy of at least one of therapeutic radiation, drug, and chemical treatment on the tumor;
determining the amount of radiation delivered in vivo to the tumor site;
monitoring radiolabeled drug uptake at the tumor site; and
analyzing the transmitted data to monitor the influence of at least one of a thermal, chemical, or radiation therapy on the tumor based on data transferred before, during and after the therapy.
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Accused Products
Abstract
Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor'"'"'s condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
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Citations
72 Claims
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1. A method of monitoring and evaluating the status of a tumor undergoing treatment, comprising the steps of:
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(a) monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment with an in situ sensor unit;
(b) transmitting data associated with the at least one monitored physiological parameter from the in situ positioned sensor unit to a receiver located external to the subject;
(c) analyzing the transmitted data to determine a condition of the tumor;
(d) repeating steps (a), (b), and (c) periodically at a plurality of sequential points in time; and
(e) evaluating a tumor treatment strategy comprising at least one of;
identifying a favorable or unfavorable tumor treatment time for administration of at least one of a radiation, drug, and chemical therapy;
evaluating the efficacy of at least one of therapeutic radiation, drug, and chemical treatment on the tumor;
determining the amount of radiation delivered in vivo to the tumor site;
monitoring radiolabeled drug uptake at the tumor site; and
analyzing the transmitted data to monitor the influence of at least one of a thermal, chemical, or radiation therapy on the tumor based on data transferred before, during and after the therapy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A tumor monitoring system for identifying enhanced active cancer treatment windows, comprising:
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at least one implantable sensor unit comprising a plurality of sensor elements and associated sensor electronics, wherein a plurality of said plurality of sensor elements are configured for in vivo in situ contact with a cancerous tumor in a subject undergoing treatment for cancer, and wherein said sensor elements are configured to detect a plurality of different parameters associated with the tumor and wirelessly transmit data associated with the detected parameters, wherein said plurality of different parameters includes at least two of the amount of radiation exposure at the tumor site, extracellular pH of the tumor, pH of normal tissue, tumor cell oxygenation, tumor cell proliferation and temperature;
a remote receiver in wireless communication with said at least one sensor, said receiver configured to receive the transmitted data, wherein said receiver is spatially separate from said at least one sensor and positioned external to the subject; and
a processor having computer readable program code for analyzing the transmitted data to identify the presence or absence of a favorable cancer treatment condition. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A computer program product for monitoring and analyzing the condition of a tumor in a patient undergoing cancer treatment, the computer program product comprising:
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a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising;
computer readable program code means for commencing a first wireless data transmission from an in situ wireless sensor with at least one sensor element positioned in a subject proximate to a tumor site undergoing treatment for cancer, the data transmission including data corresponding to the output of the at least one sensor element;
computer readable program code means for commencing a second wireless data transmission from the in situ sensor temporally separate from the first wireless data transmission;
computer readable program code means for tracking variation between the first and second data transmissions to provide a dynamic behavioral model of the tumor'"'"'s response to the treatment;
computer readable program code for analyzing the transmitted data to identify at least one favorable cancer treatment opportunity;
computer readable program code means for evaluating at least one of (a) the amount of radiation exposure delivered to the tumor site from a cancer radiation treatment session, (b) cell proliferation associated with the tumor, (c) the response of normal tissue proximate the tumor site to the cancer treatment;
(d) the value of at least one physiological or biological parameter of the tumor to evaluate efficacy of a cytotoxic or targeted drug or chemical treatment or to confirm delivery of the cytotoxic or targeted drug or chemical treatment to the tumor site, (e) a variation in the value of a physiological or biological parameter of the tumor from a predictive model, (f) the presence of an unfavorable cancer treatment period, and (g) the value of at least one physiological or biological parameter of the tumor to identify a receptiveness for a particular cancer therapy type.- View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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Specification