Apparatus and method for cannulating retinal blood vessels

• US 6,402,734 B1
• Filed: 07/02/1998
• Issued: 06/11/2002
• Est. Priority Date: 07/02/1998
• Status: Expired due to Fees

• Current Assignee: JNW Partners Limited
• Original Assignee: Jeffrey N. Weiss
• Inventors: Weiss, Jeffrey N.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US09/109,454
• Time in Patent Office: 1,440 Days
• Field of Search: 606/108, 606/204.25, 606/44, 606/13, 606/15, 606/3, 606/5, 606/17, 606/166, 606/107, 606/4, 604/166, 604/500, 604/52
• US Class Current: 604/521
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00709 Instruments for removing foreign bodies for removal of intra-ocular material A61F9/00736
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00

Abstract

An apparatus and method for safely cannulating a retinal blood vessel is described. The apparatus consists of a micropipette,micromanipulator and positioner mounted to a base which is attached to a wrist rest commonly used in eye surgery. The micropipette is connected to tubing such that a medication may be injected through the micropipette into the blood vessel or conversely, a small quantity of material may be removed from a blood vessel. Alternatively, a catheter, wire or stent may be placed through the cannula to treat or diagnose an area remote from the insertion site. The ability to cannulate a retinal blood vessel should be efficacious in the treatment of vein and artery occlusion, ocular tumors and other retinal, vascular and optic nerve disorders that would benefit from diagnosis and/or treatment.

Claims

1. A method for cannulating a retinal blood vessel, said method comprising the steps of:

(a) providing a sclerotomy site at a distance from a limbus of an eye associated with the retinal blood vessel to be cannulated;

(b) inserting a small cannula within the eye such that the cannula is overlying the retinal blood vessel;

(c) inserting the cannula within the lumen of the retinal blood vessel; and

(d) introducing medication through the cannula, removing material from the blood vessel through the cannula or inserting a catheter, wire or stent through the cannula.

2. The method for cannulating a retinal blood vessel of claim 1 further including the steps of inserting an illuminated infusion cannula through the sclerotomy site and providing a second sclerotomy site for inserting the small cannula within the eye.

3. The method for cannulating a retinal blood vessel of claim 1 further including the step of lowering intraocular pressure to cause dilation of the retinal blood vessel prior to inserting the micropipette within the lumen of the blood vessel.

4. The method for cannulating a retinal blood vessel of claim 3, further comprising the step of raising the intraocular pressure when the cannula is removed from the blood vessel to minimize hemorrhaging.

5. A microcannula for use in cannulating retinal blood vessels and retinal surgery, said microcannula comprising:

an elongated non-bendable, relatively rigid hollow body member having a single angled first end to define a relatively sharp beveled tip and a second end, said second end attached to a flexible tubing member, said body member having a first body portion associated with said beveled tip and a second body portion associated with said second end, said first body portion monolithically formed with said second body portion;

wherein said first body portion having a first length and said second body portion having a second length;

wherein the first length is substantially smaller in size than the second length;

wherein the first end of said body member is insertable through a retinal surgical sclerotomy site without being attached to the sclerotomy site, said beveled tip perforating a targeted retinal structure, wherein said first body portion is permanently disposed at an angular relationship with said second body portion such that the beveled tip is positioned substantially parallel to the targeted retinal structure to be perforated when the body member is inserted through a sclerotomy site;

wherein said angular relationship is chosen based on a specific area of a person'"'"'s retina targeted for surgery;

wherein said body member being sized such that the beveled tip can safely enter into the retinal structure;

wherein the length of said first body portion and said beveled tip causing a shelved incision in the targeted retinal structure which is self sealing upon removal of said first body portion and said beveled tip from a perforation site.

6. The microcannula of claim 5 further including a means for attaching said body member to a stabilization system;

wherein said means for attaching is a fixed handle attached to said body member at a point along said second portion near said second end.

7. The microcannula of claim 5 further including an illumination member attached to said body member.

8. The microcannula of claim 7 wherein said illumination member is a fiberoptic.

9. The microcannula of claim 5 wherein said body member is adapted for fluid communication with a tube and syringe associated with the tube.

10. The microcannula of claim 5 wherein said angular relationship is approximately 135 degrees.

11. The microcannula of claim 5 wherein said body member is constructed from glass.

12. The microcannula of claim 5 wherein said body member having an outer diameter of approximately 100 microns at its beveled end.

13. The microcannula of claim 5 wherein said elongated hollow body member having a diameter of approximately 100 microns at its beveled end.

14. The microcannula of claim 5 wherein said tip is beveled at an angle of approximately 20 degrees.

15. The microcannula of claim 5 wherein an outer diameter of a first end of said body member is smaller than an outer diameter of a second end of said body member.

16. The microcannula of claim 5 further including a protective outer tube, at least a portion of said body member disposed within said protective outer tube.

17. The microcannula of claim 5 wherein said body member having an outer diameter of no greater than approximately 100 microns at its first beveled end and an outer diameter of approximately 1 millimeter at its second end.

18. A microcannula for use in cannulating retinal blood vessels and retinal surgery, said microcannula comprising:

a relatively rigid elongated hollow body member having a single angled first end to define a relatively sharp beveled tip and a second end, said second end attached to a flexible tubing member, said body member having a first body portion associated with said beveled tip and a second body portion associated with said second end, said first body portion monolithically formed with said second body portion, said tip beveled at an angle of approximately 20 degrees, said body member having an outer diameter of no greater than approximately 100 microns at its first beveled end and an outer diameter of approximately 1 millimeter at its second end;

wherein the first end of said body member insertable through a retinal surgical sclerotomy site without being attached to the sclerotomy site, wherein said first body portion is disposed at a permanent angular relationship with said second body portion such that the beveled tip is positioned substantially parallel to a targeted retinal structure when the body member is inserted through a sclerotomy site;

wherein said angular relationship is chosen based on a specific area of a person'"'"'s retina targeted;

wherein an outer diameter at said first end of said body member is smaller than an outer diameter at said second end of said body member;

wherein said first body portion having a first length and said second body portion having a second length;

wherein the first length is smaller in size than the second length;

wherein said body member being sized such that the beveled tip and first portion of said body member can safely enter into the retinal structure;

wherein the length of said first body portion and the angle of said beveled tip causing a shelved incision in the targeted retinal structure which is self sealing upon removal of said first body portion and said beveled tip from the perforation site.

19. A microcannula for use in cannulating retinal blood vessels and retinal surgery, said microcannula comprising:

an elongated non-bendable, relatively rigid hollow body member having a single angled first end to define a relatively sharp beveled tip and a second end, said second end is associated with a tubing member, said body member having a first body portion associated with said beveled tip and a second body portion associated with said second end;

wherein said first body portion having a first length and said second body portion having a second length;

wherein the first length is substantially smaller in size than the second length;

wherein the first end of said body member is adapted for insertion through a retinal surgical sclerotomy site without being attached to the sclerotomy site, said beveled tip adapted for perforation of a targeted retinal structure, wherein said first body portion is permanently disposed at an angular relationship with said second body portion such that the beveled tip is adapted for substantially parallel positioning to the targeted retinal structure to be perforated when the body member is inserted through a sclerotomy site;

wherein said angular relationship is chosen based on a specific area of a person'"'"'s retina targeted for surgery;

wherein said body member being sized such that the beveled tip can safely enter into the retinal structure;

wherein the length of said first body portion and said beveled tip allow for a shelved incision which is self sealing upon removal of said first body portion and said beveled tip from a perforation site; and

a protective outer tube, at least a portion of said body member disposed within said protective outer tube;

wherein said body member movably disposed within said protective outer tube to allow said tip to be moved between extended to retracted positions with respect to said protective outer tube.

20. A microcannula for use in cannulating retinal blood vessels and retinal surgery, said microcannula comprising:

a substantially rigid hollow body member having a substantially sharp beveled tip first end and a second end, said body member having a first body portion associated with said beveled tip and a second body portion associated with said second end, said first body portion having a first length and said second body portion having a second length;

wherein the first length is substantially smaller in size than the second length;

wherein said first body portion is permanently disposed at an angular relationship with said second body portion; and

a protective outer tube, at least a portion of said body member disposed within said protective outer tube;

wherein said body member movably disposed within said protective outer tube to allow said tip to be moved between extended to retracted positions with respect to said protective outer tube.